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Título:
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HIV Coinfection Is Associated with low-fitness rpoB variants in rifampicin-resistant mycobacterium tuberculosis
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Autores:
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Loiseau, C. ;
Brites, D. ;
Reinhard, M. ;
Zürcher, K. ;
Borrell, S. ;
Ballif, M. ;
Fenner, L. ;
Cox, H. ;
Rutaihwa, L.K. ;
Wilkinson, R.J. ;
Yotebieng, M. ;
Jane Carter, E. ;
Abimiku, A. ;
Marcy, O. ;
Gotuzzo, E. ;
Avihingsanon, A. ;
Zetola, N. ;
Doulla, B. ;
Böttger, E.C. ;
Egger, M. ;
Gagneux, S.
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Tipo de documento:
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texto impreso
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Editorial:
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American Society for Microbiology, 2020-12-14T16:06:29Z
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Nota general:
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info:eu-repo/semantics/restrictedAccess
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
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Idiomas:
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Inglés
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Palabras clave:
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Editados por otras instituciones
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Artículos
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Artículos en revistas indizadas
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Resumen:
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We analyzed 312 drug-resistant genomes of Mycobacterium tuberculosis isolates collected from HIV-coinfected and HIV-negative TB patients from nine countries with a high tuberculosis burden. We found that rifampicin-resistant M. tuberculosis strains isolated from HIV-coinfected patients carried disproportionally more resistance-conferring mutations in rpoB that are associated with a low fitness in the absence of the drug, suggesting these low-fitness rpoB variants can thrive in the context of reduced host immunity. Copyright © 2020 Loiseau et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.
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En línea:
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http://repositorio.upch.edu.pe/handle/upch/8729
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