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Arroyo, Gianfranco ; Bustos, Javier A. ; Lescano, Andres G. ; Gonzales, Isidro ; Saavedra, Herbert ; Rodriguez, Silvia ; Pretell, E. Javier ; Bonato, Pierina S. ; Lanchote, Vera L. ; Takayanagui, Osvaldo M. ; Horton, John ; Gonzalez, Armando E. ; Gilman, Robert H. ; Garcia, Hector H. | Oxford University Press | 2019-07-04T16:59:18ZBackground: Albendazole is the drug of choice for the treatment of parenchymal neurocysticercosis, although its efficacy is suboptimal. Plasma levels of albendazole sulfoxide (ASOX), the active metabolite of albendazole, are highly variable amon[...]texto impreso
Arroyo, Gianfranco ; Bustos, Javier A. ; Lescano, Andres G. ; Gonzales, Isidro ; Saavedra, Herbert ; Rodriguez, Silvia ; Pretell, E. Javier ; Bonato, Pierina S. ; Lanchote, Vera L. ; Takayanagui, Osvaldo M. ; Horton, John ; Gonzalez, Armando E. ; Gilman, Robert H. ; Garcia, Hector H. | Oxford University Press | 2019-12-06T21:02:55ZBACKGROUND: The efficacy of albendazole therapy in patients with parenchymal neurocysticercosis (NCC) is suboptimal. Plasma levels of albendazole sulfoxide (ASOX), the active metabolite of albendazole, are highly variable among patients. We hypo[...]texto impreso
Arroyo, Gianfranco ; Rodriguez, Silvia ; Lescano, Andres G. ; Alroy, Karen A. ; Bustos, Javier A. ; Santivañez, Saul ; Gonzales, Isidro ; Saavedra, Herbert ; Pretell, E. Javier ; Gonzalez, Armando E. ; Gilman, Robert H. ; Tsang, Victor C. W. ; Garcia, Hector H. ; Cysticercosis Working Group in Peru | Oxford University Press | 2018-11-30T02:09:29ZBackground: The enzyme-linked immunoelectrotransfer blot (EITB) assay is the reference serological test for neurocysticercosis (NCC). A positive result on EITB does not always correlate with the presence of active infections in the central nervo[...]texto impreso
Alroy, Karen A. ; Arroyo, Gianfranco ; Gilman, Robert H. ; Gonzales-Gustavson, Eloy ; Gallegos, Linda ; Gavidia, Cesar M. ; Verastegui, Manuela ; Rodriguez, Silvia ; López, Teresa ; Gomez-Puerta, Luis A. ; Alroy, Joseph ; Garcia, Hector H. ; Gonzalez, Armando E. ; Cysticercosis Working Group in Peru | American Society of Tropical Medicine and Hygiene | 2018-11-30T02:09:30ZNeurocysticercosis (NCC), the infection of the human central nervous system (CNS) with larval cysts of Taenia solium causes widespread neurological morbidity. Animal models are crucial for studying the pathophysiology and treatment of NCC. Some [...]texto impreso
Lescano, Andres G. ; Pray, Ian W. ; Gonzalez, Armando E. ; Gilman, Robert H. ; Tsang, Victor C. W. ; Gamboa, Ricardo ; Guezala, M. Claudia ; Aybar, Viterbo ; Rodriguez, Silvia ; Moulton, Lawrence H. ; Leontsini, Elli ; Gonzalvez, Guillermo ; O'Neal, Seth E. ; Garcia, Hector H. ; Cysticercosis Working Group in Peru | American Society of Tropical Medicine and Hygiene | 2019-07-04T16:59:24ZThe pork tapeworm, Taenia solium, is among the leading causes of preventable epilepsy in the world and is common in rural areas of developing countries where sanitation is limited and pigs have access to human feces. Prior studies in rural vill[...]texto impreso
Tuero, Iskra ; Palma, Sandra ; Cabeza, Franco ; Saleemi, Sarah ; Rodriguez, Silvia ; Gonzales, Isidro ; Mayta, Holger ; Mahanty, Siddhartha ; Garcia, Hector H. ; Gilman, Robert H. | Public Library of Science | 2019-02-06T14:53:09ZBACKGROUND: The ability of Taenia solium to modulate the immune system likely contributes to their longevity in the human host. We tested the hypothesis that the nature of the immune response is related to the location of parasite and clinical m[...]texto impreso
Garcia, Hector H. ; Gonzalez, Armando E. ; Tsang, Victor C. W. ; O'Neal, Seth E. ; Llanos-Zavalaga, Fernando ; Gonzalvez, Guillermo ; Romero, Jaime ; Rodriguez, Silvia ; Moyano, Luz M. ; Ayvar, Viterbo ; Diaz, Andre ; Hightower, Allen ; Craig, Philip S. ; Lightowlers, Marshall W. ; Gauci, Charles G. ; Leontsini, Elli ; Gilman, Robert H. | Massachusetts Medical Society | 2019-02-06T14:45:33ZBACKGROUND: Taeniasis and cysticercosis are major causes of seizures and epilepsy. Infection by the causative parasite Taenia solium requires transmission between humans and pigs. The disease is considered to be eradicable, but data on attempts[...]texto impreso
Santivanez, Saul J. ; Rodriguez, Mary L. ; Rodriguez, Silvia ; Sako, Yashuito ; Nkouawa, Agathe ; Kobayashi, Yukuharu ; Sotomayor, Alfredo L. ; Peralta, Julio E. ; Valcarcel, Maria ; Gonzalez, Armando E. ; Garcia, Hector H. ; Ito, Akira | American Society for Microbiology | 2019-02-06T14:52:38ZDiagnosis of cystic echinococcosis (CE) is based on the identification of the cyst(s) by imaging, using immunodiagnostic tests mainly as complementary tools in clinical settings. Among the antigens used for immunodiagnosis, previous studies des[...]texto impreso
Moyano, Luz M. ; O'Neal, Seth E. ; Ayvar, Viterbo ; Gonzalvez, Guillermo ; Gamboa, Ricardo ; Vilchez, Percy ; Rodriguez, Silvia ; Reistetter, Joe ; Tsang, Victor C. W. ; Gilman, Robert H. ; Gonzalez, Armando E. ; Garcia, Hector H. | Public Library of Science | 2019-02-06T14:45:56ZBACKGROUND: Neurocysticercosis is a common helminthic infection of the central nervous system and an important cause of adult-onset epilepsy in endemic countries. However, few studies have examined associations between neurologic symptoms, serol[...]texto impreso
Coral-Almeida, Marco ; Rodriguez-Hidalgo, Richar ; Celi-Erazo, Maritza ; Garcia, Hector Hugo ; Rodriguez, Silvia ; Devleesschauwer, Brecht ; Benitez-Ortiz, Washington ; Dorny, Pierre ; Praet, Nicolas | Public Library of Science | 2020-06-10T18:12:16ZBACKGROUND: Human cysticercosis is a zoonotic disease causing severe health disorders and even death. While prevalence data become available worldwide, incidence rate and cumulative incidence figures are lacking, which limits the understanding o[...]texto impreso
Garvey, Brian T. ; Moyano, Luz M. ; Ayvar, Viterbo ; Rodriguez, Silvia ; Gilman, Robert H. ; Gonzalez, Armando E. ; Garcia, Hector H. ; O'Neal, Seth E. ; Cysticercosis Working Group in Peru | American Society of Tropical Medicine and Hygiene | 2018-11-30T22:50:33ZNeurocysticercosis causes substantial neurologic morbidity in endemic regions around the world. In this cross-sectional study, we describe the frequency of neurocysticercosis among a presumed high-risk group of people in an endemic community in [...]texto impreso
Moyano, Luz M. ; Saito, Mayuko ; Montano, Silvia M. ; Gonzalvez, Guillermo ; Olaya, Sandra ; Ayvar, Viterbo ; Gonzalez, Isidro ; Larrauri, Luis ; Tsang, Victor C. W. ; Llanos, Fernando ; Rodriguez, Silvia ; Gonzalez, Armando E. ; Gilman, Robert H. ; Garcia, Hector H. | Public Library of Science | 2020-06-10T18:12:16ZBACKGROUND: The prevalence of epilepsy added to inadequate treatment results in chronic morbidity and considerable mortality in poor populations. Neurocysticercosis (NCC), a helminthic disease of the central nervous system, is a leading cause o[...]texto impreso
Verastegui, Manuela R. ; Mejia, Alan ; Clark, Taryn ; Gavidia, Cesar M. ; Mamani, Javier ; Ccopa, Fredy ; Angulo, Noelia ; Chile, Nancy ; Carmen, Rogger ; Medina, Roxana ; Garcia, Hector H. ; Rodriguez, Silvia ; Ortega, Ynes ; Gilman, Robert H. | Elsevier | 2019-02-06T14:53:41ZNeurocysticercosis is caused by Taenia solium infecting the central nervous system and is the leading cause of acquired epilepsy and convulsive conditions worldwide. Research into the pathophysiology of the disease and appropriate treatment is h[...]texto impreso
Bustos, Javier A. ; Ninaquispe, Berenice E. ; Rodriguez, Silvia ; Castillo, Yesenia ; Yang, Susan Y. ; Gilman, Robert H. ; Dorny, Pierre ; Gabriel, Sarah ; Garcia, Hector H. ; Gonzalez, Armando E. ; Cysticercosis Working Group in Peru | American Society of Tropical Medicine and Hygiene | 2019-07-04T17:00:20ZThe pig is the natural intermediate host of Taenia solium, a parasite causing significant burden of disease in both humans and pigs. Porcine cysticercosis is traditionally detected via tongue palpation and slaughterhouse meat inspection, both wi[...]texto impreso
O'Neal, Seth E. ; Moyano, Luz M. ; Ayvar, Viterbo ; Rodriguez, Silvia ; Gavidia, Cesar ; Wilkins, Patricia P. ; Gilman, Robert H. ; Garcia, Hector H. ; Gonzalez, Armando E. | Public Library of Science | 2020-06-10T18:12:17ZBACKGROUND: Taenia solium is a major cause of preventable epilepsy in developing nations. Screening and treatment of human intestinal stage infection (taeniasis) within high-risk foci may reduce transmission and prevent epilepsy by limiting hu[...]
