|
Resumen:
|
Although epidemiological cutoff values (ECVs) have been established for Candida spp. and the triazoles, they are based on MIC data from a single laboratory. We have established ECVs for eight Candida species and fluconazole, posaconazole, and voriconazole based on wild-type (WT) MIC distributions for isolates of C. albicans (n = 11,241 isolates), C. glabrata (7,538), C. parapsilosis (6,023), C. tropicalis (3,748), C. krusei (1,073), C. lusitaniae (574), C. guilliermondii (373), and C. dubliniensis (162). The 24-h CLSI broth microdilution MICs were collated from multiple laboratories (in Canada, Brazil, Europe, Mexico, Peru, and the United States). The ECVs for distributions originating from ?6 laboratories, which included ?95% of the modeled WT population, for fluconazole, posaconazole, and voriconazole were, respectively, 0.5, 0.06 and 0.03 ?g/ml for C. albicans, 0.5, 0.25, and 0.03 ?g/ml for C. dubliniensis, 8, 1, and 0.25 ?g/ml for C. glabrata, 8, 0.5, and 0.12 ?g/ml for C. guilliermondii, 32, 0.5, and 0.25 ?g/ml for C. krusei, 1, 0.06, and 0.06 ?g/ml for C. lusitaniae, 1, 0.25, and 0.03 ?g/ml for C. parapsilosis, and 1, 0.12, and 0.06 ?g/ml for C. tropicalis. The low number of MICs (
|
