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Título:
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Screening of inmates transferred to Spain reveals a Peruvian prison as a reservoir of persistent Mycobacterium tuberculosis MDR strains and mixed infections
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Autores:
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Abascal, Estefanía ;
Herranz, Marta ;
Acosta, Fermín ;
Agapito, Juan ;
Cabibbe, Andrea M. ;
Monteserin, Johana ;
Ruiz Serrano, María Jesús ;
Gijón, Paloma ;
Fernández-González, Francisco ;
Lozano, Nuria ;
Chiner-Oms, Álvaro ;
Cáceres, Tatiana ;
Pintado, Pilar Gómez ;
Acín, Enrique ;
Valencia, Eddy ;
Muñoz, Patricia ;
Comas, Inaki ;
Cirillo, Daniela M. ;
Ritacco, Viviana ;
Gotuzzo, Eduardo ;
García de Viedma, Darío
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Tipo de documento:
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texto impreso
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Editorial:
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Nature Research, 2020-07-14T00:00:51Z
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Nota general:
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info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
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Idiomas:
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Inglés
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Palabras clave:
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Editados por otras instituciones
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Artículos
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Artículos en revistas indizadas
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Resumen:
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It is relevant to evaluate MDR-tuberculosis in prisons and its impact on the global epidemiology of this disease. However, systematic molecular epidemiology programs in prisons are lacking. A health-screening program performed on arrival for inmates transferred from Peruvian prisons to Spain led to the diagnosis of five MDR-TB cases from one of the biggest prisons in Latin America. They grouped into two MIRU-VNTR-clusters (Callao-1 and Callao-2), suggesting a reservoir of two prevalent MDR strains. A high-rate of overexposure was deduced because one of the five cases was coinfected by a pansusceptible strain. Callao-1 strain was also identified in 2018 in a community case in Spain who had been in the same Peruvian prison in 2002-5. A strain-specific-PCR tailored from WGS data was implemented in Peru, allowing the confirmation that these strains were currently responsible for the majority of the MDR cases in that prison, including a new mixed infection.
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En línea:
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http://repositorio.upch.edu.pe/handle/upch/8211
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