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Título:
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Performance of BinaxNOW G6PD deficiency point-of-care diagnostic in P vivax-infected subjects
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Autores:
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Osorio, Lyda ;
Carter, Nick ;
Arthur, Preetam ;
Bancone, Germana ;
Gopalan, Sowmya ;
Gupta, Sandeep K. ;
Noedl, Harald ;
Kochar, Sanjay K. ;
Kochar, Dhanpat K. ;
Krudsood, Srivicha ;
Lacerda, Marcus V. ;
Llanos-Cuentas, Alejandro ;
Rueangweerayut, Ronnatrai ;
Srinivasan, Ramadurai ;
Treiber, Moritz ;
Möhrle, Jörg J. ;
Green, Justin
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Tipo de documento:
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texto impreso
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Editorial:
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American Society of Tropical Medicine and Hygiene, 2019-02-06T14:57:39Z
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Nota general:
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info:eu-repo/semantics/restrictedAccess
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
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Idiomas:
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Inglés
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Palabras clave:
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Editados por otras instituciones
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Artículos
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Artículos en revistas indizadas
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Resumen:
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Accurate diagnosis of glucose-6-phosphate dehydrogenase (G6PD) deficiency is required to avoid the risk of acute hemolysis associated with 8-aminoquinoline treatment. The performance of the BinaxNOW G6PD test compared with the quantitative spectrophotometric analysis of G6PD activity was assessed in 356 Plasmodium vivax-infected subjects in Brazil, Peru, Thailand, and India. In the quantitative assay, the median G6PD activity was 8.81 U/g hemoglobin (range = 0.05-20.19), with 11 (3%) subjects identified as deficient. Sensitivity of the BinaxNOW G6PD to detect deficient subjects was 54.5% (6 of 11), and specificity was 100% (345 of 345). Room temperatures inadvertently falling outside the range required to perform the rapid test (18-25 degrees C) together with subtlety of color change and insufficient training could partially explain the low sensitivity found. Ensuring safe use of 8-aminoquinolines depends on additional development of simple, highly sensitive G6PD deficiency diagnostic tests suitable for routine use in malaria-endemic areas.
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En línea:
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http://doi.org/10.4269/ajtmh.14-0298
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