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Título:
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Natural Polymorphisms in Mycobacterium tuberculosis Conferring Resistance to Delamanid in Drug-Naive Patients
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Autores:
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Reichmuth, M.L. ;
Hömke, R. ;
Zürcher, K. ;
Sander, P. ;
Avihingsanon, A. ;
Collantes, J. ;
Loiseau, C. ;
Borrell, S. ;
Reinhard, M. ;
Wilkinson, R.J. ;
Yotebieng, M. ;
Fenner, L. ;
Böttger, E.C. ;
Gagneux, S. ;
Egger, M. ;
Keller, P.M. ;
International epidemiology Databases to Evaluate AIDS (IeDEA)
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Tipo de documento:
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texto impreso
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Editorial:
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American Society for Microbiology, 2020-12-14T16:10:06Z
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Nota general:
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info:eu-repo/semantics/restrictedAccess
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
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Idiomas:
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Inglés
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Palabras clave:
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Editados por otras instituciones
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Artículos
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Artículos en revistas indizadas
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Resumen:
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Mutations in the genes of the F420 signaling pathway of Mycobacterium tuberculosis complex, including dnn, fgd1, fbiA, fbiB, fbiC, and fbiD, can lead to delamanid resistance. We searched for such mutations among 129 M. tuberculosis strains from Asia, South America, and Africa using whole-genome sequencing; 70 (54%) strains had at least one mutation in one of the genes. For 10 strains with mutations, we determined the MIC of delamanid. We found one strain from a delamanid-naive patient carrying the natural polymorphism Tyr29del (ddn) that was associated with a critical delamanid MIC. Copyright © 2020 Reichmuth et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.
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En línea:
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http://repositorio.upch.edu.pe/handle/upch/8778
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