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Galea, Jerome T. ; Monsour, Emmi ; Nurena, Cesar R. ; Blas, Magaly M. ; Brown, Brandon | Public Library of Science | 2019-01-25T15:18:36ZPURPOSE: Human papillomavirus (HPV) is the most common sexually transmitted infection globally and is responsible for a variety of cancers in men and women. An effective HPV vaccine licensed for use in girls and boys has been indicated for-but i[...]![]()
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Rougeron, V. ; Elguero, E. ; Arnathau, C. ; Hidalgo, B.A. ; Durand, P. ; Houze, S. ; Berry, A. ; Zakeri, S. ; Haque, R. ; Alam, M.S. ; Nosten, F. ; Severini, C. ; Woldearegai, T.G. ; Mordmüller, B. ; Kremsner, P.G. ; González-Cerón, L. ; Fontecha, G. ; Gamboa, D. ; Musset, L. ; Legrand, E. ; Noya, O. ; Pumpaibool, T. ; Harnyuttanakorn, P. ; Lekweiry, K.M. ; Albsheer, M.M. ; Hamid, M.M.A. ; Boukary, A.O.M.S. ; Trape, J.-F. ; Renaud, F. ; Prugnolle, F. | Public Library of Science | 2020-12-14T16:10:08ZMore than 200 million malaria clinical cases are reported each year due to Plasmodium vivax, the most widespread Plasmodium species in the world. This species has been neglected and understudied for a long time, due to its lower mortality in com[...]![]()
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Pajuelo, Monica J. ; Eguiluz, María ; Dahlstrom, Eric ; Requena, David ; Guzman, Frank ; Ramírez, Manuel ; Sheen, Patricia ; Frace, Michael ; Sammons, Scott ; Cama, Vitaliano ; Anzick, Sarah ; Bruno, Dan ; Mahanty, Siddhartha ; Wilkins, Patricia ; Nash, Theodore ; Gonzalez, Armando ; Garcia, Hector H. ; Gilman, Robert H. ; Porcella, Steve ; Zimic, Mirko | Public Library of Science | 2019-02-06T14:53:08ZBACKGROUND: Infections with Taenia solium are the most common cause of adult acquired seizures worldwide, and are the leading cause of epilepsy in developing countries. A better understanding of the genetic diversity of T. solium will improve p[...]![]()
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Berry, Alexander S. F. ; Salazar-Sanchez, Renzo ; Castillo-Neyra, Ricardo ; Borrini-Mayori, Katty ; Chipana-Ramos, Claudia ; Vargas-Maquera, Melina ; Ancca-Juarez, Jenny ; Naquira-Velarde, Cesar ; Levy, Michael Z. ; Brisson, Dustin | Public Library of Science | 2019-12-06T21:04:41ZChanging environmental conditions, including those caused by human activities, reshape biological communities through both loss of native species and establishment of non-native species in the altered habitats. Dynamic interactions with the abio[...]![]()
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Florentini, E.A. ; Angulo, N. ; Gilman, R.H. ; Alcántara, R. ; Roncal, E. ; Antiparra, R. ; Toscano, E. ; Vallejos, K. ; Kirwan, D. ; Zimic, M. ; Sheen, P. | Public Library of Science | 2020-12-14T16:06:23ZPyrazinamide (PZA) susceptibility testing in Mycobacterium tuberculosis (Mtb) is a current area of development and PZA-resistant strains are increasingly prevalent. Previous studies have demonstrated that the detection of pyrazinoic acid (POA), [...]![]()
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Pons, Maria J. ; Gomes, Cláudia ; Aguilar, Ruth ; Barrios, Diana ; Aguilar-Luis, Miguel Angel ; Ruiz, Joaquim ; Dobaño, Carlota ; Del Valle-Mendoza, Juana ; Moncunill, Gemma | Public Library of Science | 2017-10-09T17:11:19ZAnalysis of immune responses in Bartonella bacilliformis carriers are needed to understand acquisition of immunity to Carrion’s disease and may allow identifying biomarkers associated with bacterial infection and disease phases. Serum samples fr[...]![]()
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Charles, M.K. ; Lindegren, M.L. ; Wester, C.W. ; Blevins, M. ; Sterling, T.R. ; Dung, N.T. ; Dusingize, J.C. ; Avit-Edi, D. ; Durier, N. ; Castelnuovo, B. ; Nakigozi, G. ; Cortes, C.P. ; Ballif, M. ; Fenner, L. ; Ajayi, S. ; Anastos, K. ; Bashi, J. ; Bishai, W. ; Boulle, A. ; Braitstein, P. ; Carriquiry, G. ; Carter, J.E. ; Cegielski, P. ; Chimbetete, C. ; Davies, M.-A. ; Diero, L. ; Duda, S. ; Egger, M. ; Eboua, T.F. ; Gasser, A. ; Geng, E. ; Gnokori, J.C. ; Hardwicke, L. ; Hoffmann, C. ; Huebner, R. ; Kancheya, N. ; Kiertiburanakul, S. ; Kim, P. ; Lameck, D. ; Leroy, V. ; Lewden, C. ; Mandalakas, A. ; Maskew, M. ; McKaig, R. ; Mofenson, L. ; Mpoudi-Etame, M. ; Okwara, B. ; Phiri, S. ; Prasitsuebsai, W. ; Petit, A. ; Prozesky, H. ; Reid, S.E. ; Renner, L. ; Reubenson, G. ; Sohn, A. ; Vo, Q. ; Walker, D. ; Wehbe, F. ; Wejse, C. ; Williams, C. ; Wood, R. ; Wools-Kaloustian, K. ; Yao, Z. ; Yunihastuti, E. ; Zhang, F.J. ; Zhao, H.X. ; Han, N. ; Merati, T.P. ; Wirawan, D.N. ; Yuliana, F. ; Ditangco, R. ; Uy, E. ; Bantique, R. ; Phanuphak, P. ; Ruxrungtham, K. ; Avihingsanon, A. ; Khongphattanayothin, M. ; Sungkanuparph, S. ; Sanmeema, N. ; Chaiwarith, R. ; Sirisanthana, T. ; Kotarathititum, W. ; Pham, T.T. ; Cuong, D.D. ; Ha, H.L. ; Nguyen, V.K. ; Bui, V.H. ; Nguyen, T.D. ; Sohn, A.H. ; Petersen, B. ; Cooper, D.A. ; Law, M.G. ; Jiamsakul, A. ; Boettiger, D.C. ; Wati, D.K. ; Atmikasari, L.P.P. ; Malino, I.Y. ; Nallusamy, R. ; Chan, K.C. ; Lumbiganon, P. ; Kosalaraksa, P. ; Tharnprisan, P. ; Udomphanit, T. ; Phongsamart, W. ; Wittawatmongkol, O. ; Dung, K.T.K. ; Lam, N.V. ; An, P.N. ; Loan, N.T. ; Truong, H.K. ; Du, T.Q. ; Chau, N.H. ; Do, C.V. ; Ha, M.T. ; Nipathakosol, P. ; Kariminia, A. ; Mutimura, E. ; Gitembagara, A. ; Tatwangire, J. ; Izabelle, I. ; Niyongabo, T. ; Twizere, C. ; Baramperanye, E. ; Edmonds, A. ; Yotebieng, M. ; Azinyue, I. ; Ayangma, L. ; Dickinson, D. ; Eley, B. ; Fritz, C. ; Garone, D. ; Giddy, J. ; MacPhail, P. ; Moultrie, H. ; Ndirangu, J. ; Pestilli, S. ; Rabie, H. ; Stringer, J. ; Technau, K. ; Graber, C. ; Kaeser, F. ; Keiser, O. ; Cornell, M. ; Maxwell, N. ; Zannou, D.M. ; Ahouada, C. ; Akakpo, J. ; Ahomadegbé, C. ; Gougounon-Houéto, A. ; Azon-Kouanou, A. ; Houngbé, F. ; Sehonou, J. ; Koumakpaï, S. ; Alihonou, F. ; D'Almeida, M. ; Hodonou, I. ; Hounhoui, G. ; Sagbo, G. ; Tossa-Bagnan, L. ; Adjide, H. ; Drabo, J. ; Bognounou, R. ; Dienderé, A. ; Traore, E. ; Zoungrana, L. ; Zerbo, B. ; Sawadogo, A.B. ; Zoungrana, J. ; Héma, A. ; Soré, I. ; Bado, G. ; Tapsoba, A. ; Yé, D. ; Kouéta, F. ; Ouedraogo, S. ; Ouédraogo, R. ; Hiembo, W. ; Gansonré, M. ; Messou, E. ; Gnokoro, J.C. ; Koné, M. ; Kouakou, G.M. ; Bosse, C.A. ; Brou, K. ; Assi, A.I. ; Chenal, H. ; Hawerlander, D. ; Soppi, F. ; Minga, A. ; Abo, Y. ; Yoboue, J.-M. ; Eholié, S.P. ; Amego, M.D.N. ; Andavi, V. ; Diallo, Z. ; Ello, F. ; Tanon, A.K. ; Koule, S.O. ; Anzan, K.C. ; Guehi, C. ; Aka, E.A. ; Issouf, K.L. ; Kouakou, J.-C. ; N'Gbeche, M.-S. ; Pety, T. ; Kouakou, K. ; Moh, M. ; Yao, V.A. ; Folquet, M.A. ; Dainguy, M.-E. ; Kouakou, C. ; Méa-Assande, V.T. ; Oka-Berete, G. ; Zobo, N. ; Acquah, P. ; Kokora, M.-B. ; Timité-Konan, M. ; Ahoussou, L.D. ; Assouan, J.K. ; Sami, M.F. ; Kouadio, C. ; Goka, B. ; Welbeck, J. ; Sackey, A. ; Owiafe, S.N. ; Da Silva, Z.J. ; Paulo, J. ; Rodrigues, A. ; Da Silva, D. ; Medina, C. ; Oliviera-Souto, I. ; Østergaard, L. ; Laursen, A. ; Sodemann, M. ; Aaby, P. ; Fomsgaard, A. ; Erikstrup, C. ; Eugen-Olsen, J. ; Maïga, M.Y. ; Diakité, F.F. ; Kalle, A. ; Katile, D. ; Traore, H.A. ; Minta, D. ; Cissé, T. ; Dembelé, M. ; Doumbia, M. ; Fomba, M. ; Kaya, A.S. ; Traoré, A.M. ; Traoré, H. ; Toure, A.A. ; Dicko, F. ; Sylla, M. ; Berthé, A. ; Traoré, H.C. ; Koïta, A. ; Koné, N. ; N'Diaye, C. ; Coulibaly, S.T. ; Traoré, M. ; Traoré, N. ; Charurat, M. ; Alim, G. ; Dapiap, S. ; Otu ; Igbinoba, F. ; Benson, O. ; Adebamowo, C. ; James, J. ; Obaseki ; Osakede, P. ; Olasode, J. ; Seydi, M. ; Sow, P.S. ; Diop, B. ; Manga, N.M. ; Tine, J.M. ; Bassabi, C.C. ; Sy, H.S. ; Ba, A. ; Diagne, A. ; Dior, H. ; Faye, M. ; Gueye, R.D. ; Mbaye, A.D. ; Patassi, A. ; Kotosso, A. ; Kariyare, B.G. ; Gbadamassi, G. ; Komi, A. ; Mensah-Zukong, K.E. ; Pakpame, P. ; Lawson-Evi, A.K. ; Atakouma, Y. ; Takassi, E. ; Djeha, A. ; Ephoévigah, A. ; Djibril, S.E.-H. ; Dabis, F. ; Bissagnene, E. ; Arrivé, E. ; Coffie, P. ; Ekouevi, D. ; Jaquet, A. ; Sasco, A.J. ; Amani, D. ; Azani, J.-C. ; Balestre, E. ; Bessekon, S. ; Bohossou, F. ; Gilbert, C. ; Karcher, S. ; Gonsan, J.M. ; Le Carrou, J. ; Lenaud, S. ; Nchot, C. ; Malateste, K. ; Yao, A.R. ; Siloué, B. ; Clouet, G. ; Dosso, M. ; Doring, A. ; Kouakou, A. ; Rabourdin, E. ; Rivenc, J. ; Anglaret, X. ; Ba, B. ; Essanin, J.B. ; Ciaranello, A. ; Datté, S. ; Desmonde, S. ; Diby, J.-S.E. ; Gottlieb, G.S. ; Horo, A.G. ; Kangah, S.N. ; Malvy, D. ; Meless, D. ; Mounkaila-Harouna, A. ; Ndondoki, C. ; Shiboski, C. ; Tchounga, B. ; Thiébaut, R. ; Wandeler, G. ; McGowan, C. ; Cahn, P. ; Gotuzzo, Eduardo ; Reyes, M.W. ; Grinsztejn, B. ; Pape, J.W. ; Padgett, D. ; Madero, J.S. | Public Library of Science | 2019-04-24T18:23:55ZSetting: World Health Organization advocates for integration of HIV-tuberculosis (TB) services and recommends intensive case finding (ICF), isoniazid preventive therapy (IPT), and infection control ("Three I's") for TB prevention and control amo[...]![]()
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De Cerqueira, C.C.S. ; Hünemeier, T. ; Gomez-Valdés, J. ; Ramallo, V. ; Volasko-Krause, C.D. ; Barbosa, A.A.L. ; Vargas-Pinilla, P. ; Dornelles, R.C. ; Longo, D. ; Rothhammer, F. ; Bedoya, G. ; Canizales-Quinteros, S. ; Acuña-Alonzo, V. ; Gallo, C. ; Poletti, G. ; González-José, R. ; Salzano, F.M. ; Callegari-Jacques, S.M. ; Schuler-Faccini, L. ; Ruiz-Linares, A. ; Bortolini, M.C. | Public Library of Science | 2020-06-10T18:12:17ZThe understanding of the complex genotype-phenotype architecture of human pigmentation has clear implications for the evolutionary history of humans, as well as for medical and forensic practices. Although dozens of genes have previously been as[...]![]()
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Cerqueira, Caio Cesar Silva de ; Hunemeier, Tabita ; Gomez-Valdes, Jorge ; Ramallo, Virginia ; Volasko-Krause, Carla Daiana ; Barbosa, Ana Angelica Leal ; Vargas-Pinilla, Pedro ; Dornelles, Rodrigo Ciconet ; Longo, Danae ; Rothhammer, Francisco ; Bedoya, Gabriel ; Canizales-Quinteros, Samuel ; Acuna-Alonzo, Victor ; Gallo, Carla ; Poletti, Giovanni ; González-José, Rolando ; Salzano, Francisco Mauro ; Callegari-Jacques, Sidia Maria ; Schuler-Faccini, Lavinia ; Ruiz-Linares, Andrés ; Catira Bortolini, Maria | Public Library of Science | 2020-06-10T18:12:17ZThe understanding of the complex genotype-phenotype architecture of human pigmentation has clear implications for the evolutionary history of humans, as well as for medical and forensic practices. Although dozens of genes have previously been as[...]![]()
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Asensio, Irene ; Vicente Rubiano, Marina ; Muñoz Reoyo, María Jesús ; Fernández Carrión, Eduardo ; Sánchez-Vizcaíno, José Manuel ; Carballo, Matilde | Public Library of Science | 2016We analyzed six apiaries in several natural environments with a Mediterranean ecosystem in Madrid, central Spain, in order to understand how landscape and management characteristics may influence apiary health and bee production in the long term[...]![]()
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Mayta, H. ; Romero, Y.K. ; Pando, A. ; Verastegui, M. ; Tinajeros, F. ; Bozo, R. ; Henderson-Frost, J. ; Colanzi, R. ; Flores, J. ; Lerner, R. ; Bern, C. ; Gilman, R.H. ; Chagas Working Group in Peru and Bolivia | Public Library of Science | 2019-12-06T21:04:40ZBackground: The detection of Trypanosoma cruzi genetic material in clinical samples is considered an important diagnostic tool for Chagas disease. We have previously demonstrated that PCR using clot samples yields greater sensitivity than either[...]![]()
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Mayta, Holger ; Romero, Yomara K. ; Pando, Alejandra ; Verastegui, Manuela ; Tinajeros, Freddy ; Bozo, Ricardo ; Henderson-Frost, Josephine ; Colanzi, Rony ; Flores, Jorge ; Lerner, Richard ; Bern, Caryn ; Gilman, Robert H. | Public Library of Science | 2019-07-04T17:00:16ZBACKGROUND: The detection of Trypanosoma cruzi genetic material in clinical samples is considered an important diagnostic tool for Chagas disease. We have previously demonstrated that PCR using clot samples yields greater sensitivity than either[...]![]()
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Olliaro, Piero ; Fouque, Florence ; Kroeger, Axel ; Bowman, Leigh ; Velayudhan, Raman ; Santelli, Ana Carolina ; García, Diego ; Skewes Ramm, Ronald ; Sulaiman, Lokman H. ; Sanchez Tejeda, Gustavo ; Correa Morales, Fabián ; Gozzer, Ernesto ; Basso Garrido, César ; Chan Quang, Luong ; Gutierrez, Gamaliel ; Yadon, Zaida E. ; Runge-Ranzinger, Silvia | Public Library of Science | 2018-12-03T17:02:50ZBACKGROUND: Research has been conducted on interventions to control dengue transmission and respond to outbreaks. A summary of the available evidence will help inform disease control policy decisions and research directions, both for dengue and,[...]![]()
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Datta, Sumona ; Saunders, Matthew J. ; Tovar, Marco A. ; Evans, Carlton A. | Public Library of Science | 2019-01-25T16:59:39ZIn a Perspective accompanying Sylvia and colleagues, Carlton Evans and colleagues discuss the challenge of squaring policies around tuberculosis diagnosis with the realities of clinical practice in small villages and low-resource settings.![]()
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Chamakh-Ayari, Rym ; Bras-Gonçalves, Rachel ; Bahi-Jaber, Narges ; Petitdidier, Elodie ; Markikou-Ouni, Wafa ; Aoun, Karim ; Moreno, Javier ; Carrillo, Eugenia ; Salotra, Poonam ; Kaushal, Himanshu ; Negi, Narender Singh ; Arevalo, Jorge ; Falconi-Agapito, Francesca ; Privat, Angela ; Cruz, Maria ; Pagniez, Julie ; Papierok, Gerard-Marie ; Rhouma, Faten Bel Haj ; Torres, Pilar ; Lemesre, Jean-Loup ; Chenik, Mehdi ; Meddeb-Garnaoui, Amel | Public Library of Science | 2020-06-10T18:12:17ZPSA (Promastigote Surface Antigen) belongs to a family of membrane-bound and secreted proteins present in several Leishmania (L.) species. PSA is recognized by human Th1 cells and provides a high degree of protection in vaccinated mice. We evalu[...]![]()
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Palma, Sandra ; Chile, Nancy ; Carmen-Orozco, Rogger P. ; Trompeter, Grace ; Fishbeck, Kayla ; Cooper, Virginia ; Rapoport, Laura ; Bernal-Teran, Edson G. ; Condori, Beth J. ; Gilman, Robert H. ; Verastegui, Manuela R. | Public Library of Science | 2019-07-04T17:00:16ZTaenia solium is known to cause human cysticercosis while T. saginata does not. Comparative in vitro and in vivo studies on the oncosphere and the postoncospheral (PO) forms of T. solium and T. saginata may help to elucidate why cysticercosis ca[...]![]()
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Chile, Nancy ; Clark, Taryn ; Arana, Yanina ; Ortega, Ynes R. ; Palma, Sandra ; Mejia, Alan ; Angulo, Noelia ; Kosek, Jon C. ; Kosek, Margaret ; Gomez-Puerta, Luis A. ; Garcia, Hector H. ; Gavidia, Cesar M. ; Gilman, Robert H. ; Verastegui, Manuela | Public Library of Science | 2019-02-06T14:45:12ZBACKGROUND: The transitional period between the oncosphere and the cysticercus of Taenia solium is the postoncospheral (PO) form, which has not yet been completely characterized. The aim of this work was to standardize a method to obtain T. soli[...]![]()
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Coral-Almeida, Marco ; Rodriguez-Hidalgo, Richar ; Celi-Erazo, Maritza ; Garcia, Hector Hugo ; Rodriguez, Silvia ; Devleesschauwer, Brecht ; Benitez-Ortiz, Washington ; Dorny, Pierre ; Praet, Nicolas | Public Library of Science | 2020-06-10T18:12:16ZBACKGROUND: Human cysticercosis is a zoonotic disease causing severe health disorders and even death. While prevalence data become available worldwide, incidence rate and cumulative incidence figures are lacking, which limits the understanding o[...]![]()
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Cangalaya, Carla ; Zimic, Mirko ; Marzal, Miguel ; Gonzalez, Armando E. ; Guerra-Giraldez, Cristina ; Mahanty, Siddhartha ; Nash, Theodore E. ; Garcia, Hector H. | Public Library of Science | 2019-02-06T14:53:09ZBACKGROUND: Neurocysticercosis (NCC), infection of the central nervous system by Taenia solium cysticerci, is a pleomorphic disease. Inflammation around cysticerci is the major cause of disease but is variably present. One factor modulating the[...]![]()
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Gutfraind, Alexander ; Peterson, Jennifer K. ; Billig Rose, Erica ; Arevalo-Nieto, Claudia ; Sheen, Justin ; Condori-Luna, Gian Franco ; Tankasala, Narender ; Castillo-Neyra, Ricardo ; Condori-Pino, Carlos ; Anand, Priyanka ; Naquira-Velarde, Cesar ; Levy, Michael Z. | Public Library of Science | 2019-03-05T15:23:30ZBackground: Until recently, the Chagas disease vector, Triatoma infestans, was widespread in Arequipa, Perú, but as a result of a decades-long campaign in which over 70,000 houses were treated with insecticides, infestation prevalence is now gre[...]![]()
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Moreno, Marta ; Saavedra, Marlon P. ; Bickersmith, Sara A. ; Prussing, Catharine ; Michalski, Adrian ; Tong Rios, Carlos ; Vinetz, Joseph M. ; Conn, Jan E. | Public Library of Science | 2019-01-25T15:28:04ZAnopheles darlingi, the main malaria vector in the Neotropics, has been considered to be highly anthropophilic. However, many behavioral aspects of this species remain unknown, such as the range of blood-meal sources. Barrier screens were used t[...]![]()
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Bárez López, Soledad ; Grijota Martínez, Carmen ; Liao, Xiao-Hui ; Refetoff, Samuel ; Guadaño Ferraz, Ana | Public Library of Science | 2019-12-06Patients lacking the thyroid hormone (TH) transporter MCT8 present abnormal serum levels of TH: low thyroxine and high triiodothyronine. They also have severe neurodevelopmental defects resulting from cerebral hypothyroidism, most likely due to [...]![]()
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Boni, Raquel B. De ; Peratikos, Meridith B. ; Shepherd, Bryan E. ; Grinsztejn, Beatriz ; Cortes, Claudia ; Padgett, Denis ; Gotuzzo, Eduardo ; Belaunzaran-Zamudio, Pablo F. ; Rebeiro, Peter F. ; Duda, Stephany N. ; McGowan, Catherine C. | Public Library of Science | 2018-06-18T15:26:48ZBackground The HIV care cascade has improved in Latin America over the last decade. However, the influence of alcohol and noninjected drug use (NIDU) on cascade outcomes is mostly unknown. This study estimated the association of alcohol and NIDU[...]![]()
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García, Patricia J. ; Hernández-Córdova, Gustavo ; Pourjavaheri, Paria ; Gómez-Paredes, Hilbert J. ; Sudar, Samuel ; Bayer, Angela M. | Public Library of Science | 2018-11-30T17:17:14ZINTRODUCTION: Although the worldwide incidence of tuberculosis (TB) is slowly decreasing, annual infection rates in Peru remain among the highest in the Americas. Pharmacies could play an important role in facilitating early detection of TB. How[...]![]()
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Carrillo-Larco, Rodrigo M. ; Altez-Fernandez, Carlos ; Acevedo-Rodriguez, J. Gonzalo ; Ortiz-Acha, Karol ; Ugarte-Gil, Cesar | Public Library of Science | 2019-07-04T17:00:18ZBACKGROUND: Leptospirosis is a worldwide prevalent zoonosis and chronic kidney disease (CKD) is a leading global disease burden. Because of pathophysiological changes in the kidney, it has been suggested that these conditions may be associated. [...]![]()
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Serra-Casas, Elisa ; Manrique, Paulo ; Ding, Xavier C. ; Carrasco-Escobar, Gabriel ; Alava, Freddy ; Gave, Anthony ; Rodriguez, Hugo ; Contreras-Mancilla, Juan ; Rosas-Aguirre, Angel ; Speybroeck, Niko ; Gonzalez, Iveth J. ; Rosanas-Urgell, Anna ; Gamboa, Dionicia | Public Library of Science | 2019-01-25T15:28:05ZBACKGROUND: Loop-mediated isothermal DNA amplification (LAMP) methodology offers an opportunity for point-of-care (POC) molecular detection of asymptomatic malaria infections. However, there is still little evidence on the feasibility of impleme[...]![]()
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Clouse, K. ; Blevins, M. ; Lindegren, M.L. ; Yotebieng, M. ; Nguyen, D.T. ; Omondi, A. ; Michael, D. ; Zannou, D.M. ; Carriquiry, G. ; Pettit, A. ; IeDEA ; Gotuzzo, E. ; Mejia, F. ; Carriquiry, G. | Public Library of Science | 2019-04-24T18:23:56ZObjective: Xpert MTB/RIF is recommended by the World Health Organization (WHO) as the initial tuberculosis (TB) diagnostic test in individuals suspected of HIV-associated TB. We sought to evaluate field implementation of Xpert among a cohort of [...]![]()
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Jara, Marlene ; Berg, Maya ; Caljon, Guy ; de Muylder, Geraldine ; Cuypers, Bart ; Castillo, Denis ; Maes, Ilse ; Orozco, María Del Carmen ; Vanaerschot, Manu ; Dujardin, Jean-Claude ; Arevalo, Jorge | Public Library of Science | 2019-01-25T15:28:05ZIt was recently hypothesized that Leishmania amastigotes could constitute a semi-quiescent stage characterized by low replication and reduced metabolic activity. This concept developed with Leishmania (Leishmania) mexicana and Leishmania (Leishm[...]![]()
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Prussing, Catharine ; Saavedra, Marlon P. ; Bickersmith, Sara A. ; Alava, Freddy ; Guzman, Mitchel ; Manrique, Edgar ; Carrasco-Escobar, Gabriel ; Moreno, Marta ; Gamboa, Dionicia ; Vinetz, Joseph M. ; Conn, Jan E. | Public Library of Science | 2019-07-04T17:00:18ZIn Amazonian Peru, the primary malaria vector, Nyssorhynchus darlingi (formerly Anopheles darlingi), is difficult to target using standard vector control methods because it mainly feeds and rests outdoors. Larval source management could be a use[...]![]()
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Prussing, C. ; Saavedra, M.P. ; Bickersmith, S.A. ; Alava, F. ; Guzmán, M. ; Manrique, E. ; Carrasco-Escobar, G. ; Moreno, M. ; Gamboa, D. ; Vinetz, J.M. ; Conn, J.E. | Public Library of Science | 2019-12-06T20:57:51ZIn Amazonian Peru, the primary malaria vector, Nyssorhynchus darlingi (formerly Anopheles darlingi), is difficult to target using standard vector control methods because it mainly feeds and rests outdoors. Larval source management could be a use[...]![]()
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Alva, Alicia ; Cangalaya, Carla ; Quiliano, Miguel ; Krebs, Casey ; Gilman, Robert H. ; Sheen, Patricia ; Zimic, Mirko | Public Library of Science | 2019-01-25T15:28:05ZParasitic infections are generally diagnosed by professionals trained to recognize the morphological characteristics of the eggs in microscopic images of fecal smears. However, this laboratory diagnosis requires medical specialists which are lac[...]![]()
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Errea, Renato A. ; Vasquez-Rios, George ; Machicado, Jorge D. ; Gallardo, Maria Susana ; Cornejo, Marilhia ; Urquiaga, Jorge F. ; Montoya, Diego ; Zamudio, Rodrigo ; Terashima, Angélica ; Marcos, Luis A. ; Samalvides, Frine | Public Library of Science | 2019-02-06T14:53:09ZIn developing countries, education to health-care professionals is a cornerstone in the battle against neglected tropical diseases (NTD). Studies evaluating the level of knowledge of medical students in clinical and socio-demographic aspects o[...]![]()
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Valenciano, Alberto ; Baskin, Jon A. ; Abella, Juan ; Pérez-Ramos, Alejandro ; Ángeles Álvarez-Sierra, Ángeles ; Morales, Jorge ; Hartstone-Rose, Adam | Public Library of Science | 2016-04We describe cranial and mandibular remains of three undescribed individuals of the giant mustelid Megalictis ferox Matthew, 1907 from the latest Arikareean (Ar4), Early Miocene mammal fauna of Nebraska, and Wyoming (USA) housed at the American M[...]![]()
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Benziger, Catherine P. ; Bernabé-Ortiz, Antonio ; Gilman, Robert H. ; Checkley, William ; Smeeth, Liam ; Malaga, German ; Miranda, J. Jaime | Public Library of Science | 2019-02-06T14:53:10ZOBJECTIVE: We aimed to characterize metabolic status by body mass index (BMI) status. METHODS: The CRONICAS longitudinal study was performed in an age-and-sex stratified random sample of participants aged 35 years or older in four Peruvian set[...]![]()
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Guevara, Govinda ; Olortegui Flores, Yamileth ; Fernández de las Heras, Laura ; Perera González, Julián ; Navarro LLorens, Juana María | Public Library of Science | 2019-07-26Rhodococcus ruber Chol-4 is a potent steroid degrader that has a great potential as a biotechnological tool. As proof of concept, this work presents testosterone production from 4- androstene-3,17-dione by tailoring innate catabolic enzymes of t[...]![]()
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Faggion, C. M. ; Apaza, K. ; Ariza-Fritas, T. ; Malaga, L. ; Giannakopoulos, N. N. ; Alarcon, M. A. | Public Library of Science | 2019-01-25T16:36:29ZBackground Consensus guidelines are useful to improve clinical decision making. Therefore, the methodological evaluation of these guidelines is of paramount importance. Low quality information may guide to inadequate or harmful clinical decision[...]![]()
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Oriol-Tordera, B. ; Berdasco, M. ; Llano, A. ; Mothe, B. ; Gálvez, C. ; Martinez-Picado, J. ; Carrillo, J. ; Blanco, J. ; Duran-Castells, C. ; Ganoza, C. ; Sánchez, J. ; Clotet, B. ; Calle, M.L. ; Sánchez-Pla, A. ; Esteller, M. ; Brander, C. ; Ruiz-Riol, M. | Public Library of Science | 2020-12-14T16:10:02ZGWAS, immune analyses and biomarker screenings have identified host factors associated with in vivo HIV-1 control. However, there is a gap in the knowledge about the mechanisms that regulate the expression of such host factors. Here, we aimed to[...]![]()
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Vasquez, Ana L. ; Errea, Renato A. ; Hoces, Daniel ; Echevarria, Juan ; González-Lagos, Elsa ; Gotuzzo, Eduardo | Public Library of Science | 2019-01-25T15:28:06ZINTRODUCTION: Based on the hypothesis that HIV programs struggle to deliver health services that harmonize necessities of treatment and prevention, we described the outcomes of routinely provided HIV testing to partners of people living with HIV[...]![]()
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Torres-Roman, J. Smith ; Cruz-Avila, Yuridia ; Suarez-Osorio, Karina ; Arce-Huamaní, Miguel Ángel ; Menez-Sanchez, Alejandra ; Aveiro-Róbalo, Telmo Raúl ; Mejia, Christian R. ; Ruiz, Eloy F. | Public Library of Science | 2018-11-30T17:17:16ZINTRODUCTION: Motivation in medical students is positively associated with learning strategies. However, the evidence of a direct relationship between motivation and performance is vague. The objective of this study is to determine if the motiva[...]![]()
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Rodríguez, L. ; Bustamante, B. ; Huaroto, L. ; Agurto, C. ; Illescas, R. ; Ramírez, R. ; Diaz, A. ; Hidalgo, J. | Public Library of Science | 2019-01-25T16:36:29ZBackground The incidence of candidemia is increasing in developing countries. Very little is known about the epidemiology of candidemia in Peru. The aim of this study is to describe the incidence, microbiology, clinical presentation and outcomes[...]![]()
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Zavaleta, Carol ; Berrang-Ford, Lea ; Ford, James ; Llanos-Cuentas, Alejandro ; Carcamo, Cesar ; Ross, Nancy A. ; Lancha, Guillermo ; Sherman, Mya ; Harper, Sherilee L. ; Edge, Victoria ; Lwasa, Shuaib ; Namanya, Didacus B. | Public Library of Science | 2018-11-08T19:39:21ZBackground Climate change is affecting food systems globally, with implications for food security, nutrition, and the health of human populations. There are limited data characterizing the current and future consequences of climate change on loc[...]![]()
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Cura, Carolina I. ; Duffy, Tomas ; Lucero, Raul H. ; Bisio, Margarita ; Peneau, Julie ; Jimenez-Coello, Matilde ; Calabuig, Eva ; Gimenez, Maria J. ; Valencia Ayala, Edward ; Kjos, Sonia A. ; Santalla, Jose ; Mahaney, Susan M. ; Cayo, Nelly M. ; Nagel, Claudia ; Barcan, Laura ; Malaga Machaca, Edith S. ; Acosta Viana, Karla Y. ; Brutus, Laurent ; Ocampo, Susana B. ; Aznar, Christine ; Cuba Cuba, Cesar A. ; Gurtler, Ricardo E. ; Ramsey, Janine M. ; Ribeiro, Isabela ; VandeBerg, John L. ; Yadon, Zaida E. ; Osuna, Antonio ; Schijman, Alejandro G. | Public Library of Science | 2019-02-06T14:53:10ZBACKGROUND: Trypanosoma cruzi has been classified into six Discrete Typing Units (DTUs), designated as TcI-TcVI. In order to effectively use this standardized nomenclature, a reproducible genotyping strategy is imperative. Several typing scheme[...]![]()
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Moyano, Luz M. ; Saito, Mayuko ; Montano, Silvia M. ; Gonzalvez, Guillermo ; Olaya, Sandra ; Ayvar, Viterbo ; Gonzalez, Isidro ; Larrauri, Luis ; Tsang, Victor C. W. ; Llanos, Fernando ; Rodriguez, Silvia ; Gonzalez, Armando E. ; Gilman, Robert H. ; Garcia, Hector H. | Public Library of Science | 2020-06-10T18:12:16ZBACKGROUND: The prevalence of epilepsy added to inadequate treatment results in chronic morbidity and considerable mortality in poor populations. Neurocysticercosis (NCC), a helminthic disease of the central nervous system, is a leading cause o[...]![]()
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Pesantes, M.A. ; Moyano, L.M. ; Sommerville, C. ; Cysticercosis Working Group in Peru COHESION Project | Public Library of Science | 2020-12-14T16:10:04ZBackground Neurocysticercosis (NCC) is a helminthic disease of the central nervous system, and it is one of the leading causes of seizures and symptomatic epilepsy in countries with tropical regions like Peru. Studies of people with epilepsy in [...]![]()
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Ong, Catherine W. M. ; Elkington, Paul T. ; Brilha, Sara ; Ugarte-Gil, Cesar ; Tome-Esteban, Maite T. ; Tezera, Liku B. ; Pabisiak, Przemyslaw J. ; Moores, Rachel C. ; Sathyamoorthy, Tarangini ; Patel, Vimal ; Gilman, Robert H. ; Porter, Joanna C. ; Friedland, Jon S. | Public Library of Science | 2019-02-06T14:53:12ZPulmonary cavities, the hallmark of tuberculosis (TB), are characterized by high mycobacterial load and perpetuate the spread of M. tuberculosis. The mechanism of matrix destruction resulting in cavitation is not well defined. Neutrophils are e[...]![]()
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Arriola, Carmen S. ; Gonzalez, Armando E. ; Gomez-Puerta, Luis A. ; Lopez-Urbina, Maria T. ; Garcia, Hector H. ; Gilman, Robert H. | Public Library of Science | 2020-06-10T18:12:17ZTaenia solium infection causes severe neurological disease in humans. Even though infection and exposure to swine cysticercosis is scattered throughout endemic villages, location of the tapeworm only explains some of the nearby infections and is[...]![]()
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Limaye, Neha P. ; Rivas-Nieto, Andrea C. ; Carcamo, Cesar P. ; Blas, Magaly M. | Public Library of Science | 2018-11-30T22:50:34ZBACKGROUND: In rural areas of the Loreto region within the Peruvian Amazon, maternal mortality rate is above the national average and the majority of women deliver at home without care from a trained health care provider. METHODS: To develop com[...]![]()
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Loret de Mola, Christian ; Quispe, Renato ; Valle, Giancarlo A. ; Poterico, Julio A. | Public Library of Science | 2020-06-10T18:12:17ZBACKGROUND: Rapid urbanization, increase in food availability, and changes in diet and lifestyle patterns have been changing nutritional profiles in developing nations. We aimed to describe nutritional changes in children under 5 years and women[...]![]()
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Flores-Flores, Oscar ; Bell, Ruth ; Reynolds, Rodney ; Bernabé-Ortiz, Antonio | Public Library of Science | 2019-03-05T15:23:30ZBACKGROUND: Disability rates increase with age. In 2012, Peruvian older adults (> /= 65 years) represented 9% of the population. Additionally, older population reported disabilities at about 5 times the rate of Peruvians between 36 and 64 years [...]![]()
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Datta, S. ; Alvarado, K. ; Gilman, R.H. ; Valencia, T. ; Aparicio, C. ; Ramos, E.S. ; Montoya, R. ; Evans, C.A. | Public Library of Science | 2019-12-06T21:04:41ZBackground Assessing Mycobacterium tuberculosis (TB) viability by fluorescein diacetate (FDA) microscopy can predict TB culture results, treatment response and infectiousness. However, diverse methods have been published. We aimed to optimise FD[...]![]()
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Datta, Sumona ; Alvarado, Keren ; Gilman, Robert H. ; Valencia, Teresa ; Aparicio, Christian ; Ramos, Eric S. ; Montoya, Rosario ; Evans, Carlton A. | Public Library of Science | 2019-07-04T17:00:20ZBACKGROUND: Assessing Mycobacterium tuberculosis (TB) viability by fluorescein diacetate (FDA) microscopy can predict TB culture results, treatment response and infectiousness. However, diverse methods have been published. We aimed to optimise F[...]![]()
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Rodelo-Haad, Cristian ; Agüera, María Luisa ; Carmona, Andrés ; Navarro, María Dolores ; Carracedo, Julia ; Rodríguez-Benot, Alberto ; Aljama, Pedro | Public Library of Science | 2019-02-22Pancreatic autoantibodies (AAb) has been associated with a worse pancreas graft survival after simultaneous pancreas-kidney transplantation (SPK). However, due to the variable time for AAb to become positive and the lack of early biomarkers sugg[...]![]()
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Llopis, Silvia ; Hernández Haro, Carolina ; Monteoliva Díaz, Lucía ; Querol, Amparo ; Molina, María ; Fernández Espinar, María T. | Public Library of Science | 2014-05-30Saccharomyces cerevisiae plays a beneficial role in health because of its intrinsic nutritional value and bio-functional properties, which is why it is also used as a dietary supplement. However, the perception that S. cerevisiae is harmless has[...]![]()
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Lackey, Brian ; Seas, Carlos ; Van der Stuyft, Patrick ; Otero, Larissa | Public Library of Science | 2019-02-06T14:53:10ZBACKGROUND: Although tuberculosis (TB) is usually curable with antibiotics, poor adherence to medication can lead to increased transmission, drug resistance, and death. Prior research has shown several factors to be associated with poor adhere[...]![]()
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Prochazka, Mateo ; Otero, Larissa ; Konda, Kelika A. ; González-Lagos, Elsa ; Echevarria, Juan ; Gotuzzo, Eduardo | Public Library of Science | 2018-06-18T15:26:48ZPatient-nominated supporters can potentially improve the continuum of HIV care. We retrospectively determined factors associated with having a patient-nominated supporter among people living with HIV (PLWH), and its association with retention in[...]![]()
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Erber, Astrid C. ; Arana, Byron ; Ben Salah, Afif ; Bennis, Issam ; Boukthir, Aicha ; Castro Noriega, Maria Del Mar ; Cissé, Mamoudou ; Cota, Gláucia Fernandes ; Handjani, Farhad ; López-Carvajal, Liliana ; Marsh, Kevin ; Medina, Dalila Martínez ; Plugge, Emma ; Lang, Trudie ; Olliaro, Piero | Public Library of Science | 2020-07-14T00:01:09ZBACKGROUND: Cutaneous leishmaniasis (CL) is a disease that often affects exposed skin areas and may heal leaving lifelong scars. Patients' expectations from treatment are rarely considered in drug development for CL. An initiative aiming to addr[...]![]()
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Pascual Ezama, David ; Dunfield, Derek ; Gil-Gómez de Liaño, Beatriz ; Prelec, Drazen | Public Library of Science | 2015-04-08Recent empirical evidence shows that working in an unsupervised, isolated situation under competition, can increase dishonest behavior to achieve prestige. However, could working in a common space, in the presence of colleagues affect cheating? [...]![]()
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BACKGROUND: Behavior change theories can identify people's main motivations to engage in recommended health practices and thus provide better tools to design interventions, particularly human centered design interventions. OBJECTIVES: This study[...]![]()
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Vidal, E. Jair ; Alvarez, Daily ; Martinez-Velarde, Dalia ; Vidal-Damas, Lorena ; Yuncar-Rojas, Kelly A. ; Julca-Malca, Alesia ; Bernabé-Ortiz, Antonio | Public Library of Science | 2018-11-30T22:50:35ZOBJECTIVES: Different studies have reported the association between perceived stress and unhealthy diet choices. We aimed to determine whether there is a relationship between perceived stress and fat intake among undergraduate medical students. [...]![]()
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Albino, Sandra ; Tabb, Karen M. ; Requena, David ; Egoavil, Miguel ; Pineros-Leano, Maria F. ; Zunt, Joseph R. ; García, Patricia J. | Public Library of Science | 2020-06-10T18:12:17ZBACKGROUND: Tuberculosis (TB) is global health concern and a leading infectious cause of mortality. Reversing TB incidence and disease-related mortality is a major global health priority. Infectious disease mortality is directly linked to failu[...]![]()
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Cangalaya, Carla ; Bustos, Javier-A. ; Calcina, Juan ; Vargas-Calla, Ana ; Suarez, Diego ; Gonzalez, Armando-E. ; Chacaltana, Juan ; Guerra-Giraldez, Cristina ; Mahanty, Siddhartha ; Nash, Theodore-E. ; Garcia, Hector-H. | Public Library of Science | 2019-02-06T14:45:11ZBACKGROUND: Disease manifestations in neurocysticercosis (NCC) are frequently due to inflammation of degenerating Taenia solium brain cysts. Exacerbated inflammation post anthelmintic treatment is associated with leakage of the blood brain barr[...]![]()
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Koepfli, Cristian ; Rodrigues, Priscila T. ; Antao, Tiago ; Orjuela-Sanchez, Pamela ; Van den Eede, Peter ; Gamboa, Dionicia ; van Hong, Nguyen ; Bendezu, Jorge ; Erhart, Annette ; Barnadas, Celine ; Ratsimbasoa, Arsene ; Menard, Didier ; Severini, Carlo ; Menegon, Michela ; Nour, Bakri Y. M. ; Karunaweera, Nadira ; Mueller, Ivo ; Ferreira, Marcelo U. ; Felger, Ingrid | Public Library of Science | 2019-02-06T14:53:10ZPlasmodium vivax is the geographically most widespread human malaria parasite. To analyze patterns of microsatellite diversity and population structure across countries of different transmission intensity, genotyping data from 11 microsatellite [...]![]()
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Pham, Thanh Vinh ; Nguyen, Hong Van ; Aguirre, Angel Rosas ; Nguyen, Van Van ; A Cleves, Mario ; Nguyen, Xa Xuan ; Nguyen, Thao Thanh ; Tran, Duong Thanh ; Le, Hung Xuan ; Hens, Niel ; Rosanas-Urgell, Anna ; D'Alessandro, Umberto ; Speybroeck, Niko ; Erhart, Annette | Public Library of Science | 2019-07-04T17:00:20ZBACKGROUND: In Vietnam, the importance of vivax malaria relative to falciparum during the past decade has steadily increased to 50%. This, together with the spread of multidrug-resistant Plasmodium falciparum, is a major challenge for malaria el[...]![]()
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Pham, T.V. ; Van Nguyen, H. ; Aguirre, A.R. ; Van Nguyen, V. ; Cleves, M.A. ; Nguyen, X.X. ; Nguyen, T.T. ; Tran, D.T. ; Le, H.X. ; Hens, N. ; Rosanas-Urgell, A. ; D’alessandro, U. ; Speybroeck, N. ; Erhart, A. | Public Library of Science | 2019-12-06T21:02:52ZBackground In Vietnam, the importance of vivax malaria relative to falciparum during the past decade has steadily increased to 50%. This, together with the spread of multidrug-resistant Plasmodium falciparum, is a major challenge for malaria eli[...]![]()
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Málaga-Machaca, Edith S. ; Romero-Ramirez, Alessandra ; Gilman, Robert H. ; Astupiña-Figueroa, Sofía ; Angulo, Noelia ; Florentini, Alejandro ; Lovon-Luque, Cinthya J. ; Gonza, Remo A. ; Del Carpio-Sanz, Ada ; Cabello, Ines ; Camargo, Rosina ; Recuenco, Fernando ; Barrueta-Soria, Liliam A. ; Verastegui, Manuela R. ; Calderón, Maritza ; Mayta, Holger | Public Library of Science | 2019-01-25T15:28:07ZBACKGROUND: Detection of Trypanosoma cruzi antigens in clinical samples is considered an important diagnostic tool for Chagas disease. The production and use of polyclonal antibodies may contribute to an increase in the sensitivity of immunodiag[...]![]()
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Castano, A. G. ; de Nanclares, G. P. ; Madariaga, L. ; Aguirre, M. ; Madrid, A. ; Chocron, S. ; Nadal, I. ; Navarro, M. ; Lucas, E. ; Fijo, J. ; Espino, M. ; Espitaletta, Z. ; Nieto, V. G. ; de Frutos, D. B. ; Loza, R. ; Pintos, G. ; Castaño, L. ; Ariceta, G. ; RenalTube Group | Public Library of Science | 2019-01-25T16:36:29ZIntroduction Type III Bartter syndrome (BS) is an autosomal recessive renal tubule disorder caused by loss-of-function mutations in the CLCNKB gene, which encodes the chloride channel protein ClC-Kb. In this study, we carried out a complete clin[...]![]()
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Delgado-Ratto, Christopher ; Gamboa, Dionicia ; Soto-Calle, Veronica-E. ; Van-den-Eede, Peter ; Torres, Eliana ; Sanchez-Martinez, Luis ; Contreras-Mancilla, Juan ; Rosanas-Urgell, Anna ; Rodriguez-Ferrucci, Hugo ; Llanos-Cuentas, Alejandro ; Erhart, Annette ; Van-Geertruyden, Jean-Pierre ; D'Alessandro, Umberto | Public Library of Science | 2019-02-06T14:45:12ZBACKGROUND: Characterizing the parasite dynamics and population structure provides useful information to understand the dynamic of transmission and to better target control interventions. Despite considerable efforts for its control, vivax malar[...]![]()
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Sikora, Martin ; Carpenter, Meredith L. ; Moreno-Estrada, Andres ; Henn, Brenna M. ; Underhill, Peter A. ; Sanchez-Quinto, Federico ; Zara, Ilenia ; Pitzalis, Maristella ; Sidore, Carlo ; Busonero, Fabio ; Maschio, Andrea ; Angius, Andrea ; Jones, Chris ; Mendoza-Revilla, Javier ; Nekhrizov, Georgi ; Dimitrova, Diana ; Theodossiev, Nikola ; Harkins, Timothy T. ; Keller, Andreas ; Maixner, Frank ; Zink, Albert ; Abecasis, Goncalo ; Sanna, Serena ; Cucca, Francesco ; Bustamante, Carlos D. | Public Library of Science | 2020-06-10T18:12:16ZGenome sequencing of the 5,300-year-old mummy of the Tyrolean Iceman, found in 1991 on a glacier near the border of Italy and Austria, has yielded new insights into his origin and relationship to modern European populations. A key finding of th[...]![]()
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Khatchikian, Camilo E. ; Foley, Erica A. ; Barbu, Corentin M. ; Hwang, Josephine ; Ancca-Juarez, Jenny ; Borrini-Mayori, Katty ; Quispe-Machaca, Victor R. ; Náquira, César ; Brisson, Dustin ; Levy, Michael Z. | Public Library of Science | 2019-02-06T14:53:10ZChagas disease is a vector-borne disease endemic in Latin America. Triatoma infestans, a common vector of this disease, has recently expanded its range into rapidly developing cities of Latin America. We aim to identify the environmental featu[...]![]()
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Mahanty, Siddhartha ; Orrego, Miguel Angel ; Mayta, Holger ; Marzal, Miguel ; Cangalaya, Carla ; Paredes, Adriana ; Gonzales-Gustavson, Eloy ; Arroyo, Gianfranco ; Gonzalez, Armando E. ; Guerra-Giraldez, Cristina ; Garcia, Hector H. ; Nash, Theodore E. | Public Library of Science | 2019-02-06T14:53:10ZCysticidal treatment of neurocysticercosis, an infection of humans and pig brains with Taenia solium, results in an early inflammatory response directed to cysts causing seizures and focal neurological manifestations. Treatment-induced pericysti[...]![]()
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Marco López, Eva María ; Rapino, Cinzia ; Caprioli, Antonio ; Borsini, Franco ; Laviola, Giovanni ; Maccarrone, Mauro | Public Library of Science | 2015-09-11Anxiety disorders are among the most prevalent psychiatric diseases with high personal costs and a remarkable socio-economic burden. However, current treatment of anxiety is far from satisfactory. Novel pharmacological targets have emerged in th[...]![]()
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Paz-Soldan, Valerie A. ; Morrison, Amy C. ; Sopheab, Heng ; Schwarz, Julia ; Bauer, Karin M. ; Mckenney, Jennie L. ; Chhea, Chhorvann ; Saphonn, Vonthanak ; Khuon, Dyna ; Hontz, Robert D. ; Gorbach, Pamina M. | Public Library of Science | 2019-12-06T21:02:53ZIn 2012, the U.S. Defense Threat Reduction Agency Joint Science and Technology Office initiated a program to develop novel point-of-need diagnostic devices for surveillance of emerging infectious diseases including dengue, malaria, plague, and [...]![]()
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Supo-Escalante, R.R. ; Médico, A. ; Gushiken, E. ; Olivos-Ramírez, G.E. ; Quispe, Y. ; Torres, F. ; Zamudio, M. ; Antiparra, R. ; Mario Amzel, L. ; Gilman, R.H. ; Sheen, P. ; Zimic, M. | Public Library of Science | 2020-12-14T16:10:16ZBackground: Pyrazinamide is an important drug against the latent stage of tuberculosis and is used in both first- and second-line treatment regimens. Pyrazinamide-susceptibility test usually takes a week to have a diagnosis to guide initial ther[...]![]()
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Rovira-Vallbona, Eduard ; Contreras-Mancilla, Juan José ; Ramirez, Roberson ; Guzmán-Guzmán, Mitchel ; Carrasco-Escobar, Gabriel ; Llanos-Cuentas, Alejandro ; Vinetz, Joseph M. ; Gamboa, Dionicia ; Rosanas-Urgell, Anna | Public Library of Science | 2019-01-25T15:28:08ZMalaria transmission requires that Anopheles mosquitoes ingest Plasmodium gametocyte stages circulating in the human bloodstream. In the context of malaria elimination, understanding the epidemiology of gametocytes relative to all Plasmodium inf[...]![]()
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Alroy, K.A. ; Huang, C. ; Gilman, R.H. ; Quispe-Machaca, V.R. ; Marks, M.A. ; Ancca-Juarez, J. ; Hillyard, M. ; Verastegui, M. ; Sanchez, G. ; Cabrera, L. ; Vidal, E. ; Billig, E.M.W. ; Cama, V.A. ; Naquira, C. ; Bern, C. ; Levy, M.Z. ; Working Group on Chagas Disease in Peru | Public Library of Science | 2019-04-24T18:23:55ZVector-borne transmission of Trypanosoma cruzi is seen exclusively in the Americas where an estimated 8 million people are infected with the parasite. Significant research in southern Peru has been conducted to understand T. cruzi infection and [...]![]()
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Villegas, Leonela ; Otero, Larissa ; Sterling, Timothy-R. ; Huaman, Moises-A. ; Van-der-Stuyft, Patrick ; Gotuzzo, Eduardo ; Seas, Carlos | Public Library of Science | 2019-02-06T14:48:07ZBACKGROUND: Isoniazid and rifampicin are the two most efficacious first-line agents for tuberculosis (TB) treatment. We assessed the prevalence of isoniazid and rifampicin mono-resistance, associated risk factors, and the association of mono-res[...]![]()
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Patra, Kailash P. ; Saito, Mayuko ; Atluri, Vidya L. ; Rolan, Hortensia G. ; Young, Briana ; Kerrinnes, Tobias ; Smits, Henk ; Ricaldi, Jessica N. ; Gotuzzo, Eduardo ; Gilman, Robert H. ; Tsolis, Renee M. ; Vinetz, Joseph M. | Public Library of Science | 2020-06-10T18:12:16ZHuman brucellosis is most commonly diagnosed by serology based on agglutination of fixed Brucella abortus as antigen. Nucleic acid amplification techniques have not proven capable of reproducibly and sensitively demonstrating the presence of B[...]![]()
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Zamudio, Carlos ; Krapp, Fiorella ; Choi, Howard W. ; Shah, Lena ; Ciampi, Antonio ; Gotuzzo, Eduardo ; Heymann, Jody ; Seas, Carlos ; Brewer, Timothy F. | Public Library of Science | 2019-02-06T14:53:12ZBACKGROUND: Tuberculosis (TB) transmission may occur with exposure to an infectious contact often in the setting of household environments, but extra-domiciliary transmission also may happen. We evaluated if using buses and/or minibuses as publi[...]![]()
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Suarez, Milagros ; Valencia, B. M. ; Jara, Marlene ; Alba, Milena ; Boggild, Andrea K. ; Dujardin, Jean-Claude ; Llanos-Cuentas, Alejandro ; Arevalo, Jorge ; Adaui, Vanessa | Public Library of Science | 2019-02-06T14:53:09ZBACKGROUND: Cutaneous leishmaniasis (CL) is a skin disease caused by the protozoan parasite Leishmania. Few studies have assessed the influence of the sample collection site within the ulcer and the sampling method on the sensitivity of parasito[...]![]()
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Cangalaya, Carla ; Bustos, Javier A. ; Calcina, Juan ; Vargas-Calla, Ana ; Mamani, Javier ; Suarez, Diego ; Arroyo, Gianfranco ; Gonzalez, Armando E. ; Chacaltana, Juan ; Guerra-Giraldez, Cristina ; Mahanty, Siddhartha ; Nash, Theodore E. ; Garcia, Hector H. | Public Library of Science | 2019-01-25T16:03:19ZBACKGROUND: The onset of anthelmintic treatment of neurocysticercosis (NCC) provokes an acute immune response of the host, which in human cases is associated with exacerbation of neurological symptoms. This inflammation can occur at the first da[...]![]()
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Mallma, Patricia ; Garcia, Patricia ; Carcamo, Cesar ; Torres-Rueda, Sergio ; Peeling, Rosanna ; Mabey, David ; Terris-Prestholt, Fern | Public Library of Science | 2019-02-06T14:45:55ZStudies have addressed cost-effectiveness of syphilis testing of pregnant women in high-prevalence settings. This study compares costs of rapid syphilis testing (RST) with laboratory-based rapid plasma reagin (RPR) tests in low-prevalence setti[...]![]()
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Fontoura, Pablo-S. ; Finco, Bruna-F. ; Lima, Nathalia-F. ; de-Carvalho, Jaques-F. Jr ; Vinetz, Joseph-M. ; Castro, Marcia-C. ; Ferreira, Marcelo-U. | Public Library of Science | 2019-02-06T14:45:13ZBACKGROUND: Malaria burden in Brazil has reached its lowest levels in 35 years and Plasmodium vivax now accounts for 84% of cases countrywide. Targeting residual malaria transmission entrenched in the Amazon is the next major challenge for ongoi[...]![]()
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Agampodi, Suneth B. ; Dahanayaka, Niroshan J. ; Bandaranayaka, Anoma K. ; Perera, Manoj ; Priyankara, Sumudu ; Weerawansa, Prasanna ; Matthias, Michael A. ; Vinetz, Joseph M. | Public Library of Science | 2020-06-10T18:12:16ZLeptospirosis is known to be an important cause of weather disaster-related infectious disease epidemics. In 2011, an outbreak of leptospirosis occurred in the relatively dry district of Anuradhapura, Sri Lanka where diagnosis was resisted by lo[...]![]()
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Malpica, Luis ; White, A. Clinton Jr ; Leguia, Cristina ; Freundt, Natalia ; Barros, Nicolas ; Chian, Cesar ; Antunez, E. Antonio ; Montes, Martin | Public Library of Science | 2019-12-06T20:57:44ZBACKGROUND: Strongyloides stercoralis is an intestinal nematode unique in its ability to replicate in the human host, allowing ongoing cycles of autoinfection, persisting for decades within the same host. Although usually asymptomatic, overwhelm[...]![]()
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Malpica, Luis ; White, A. Clinton Jr ; Leguia, Cristina ; Freundt, Natalia ; Barros, Nicolas ; Chian, Cesar ; Antunez, E. Antonio ; Montes, Martin | Public Library of Science | 2019-07-04T17:00:21ZBACKGROUND: Strongyloides stercoralis is an intestinal nematode unique in its ability to replicate in the human host, allowing ongoing cycles of autoinfection, persisting for decades within the same host. Although usually asymptomatic, overwhelm[...]![]()
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Díaz-Real, Javier ; Serrano, David ; Pérez Tris, Javier ; Fernández González, Sofía ; Bermejo, Ana ; Calleja, Juan A. ; Puente, Javier de la ; Palacio, Diana de ; Martínez, José L. ; Moreno-Opo Díaz-Meco, Rubén ; Ponce, Carlos ; Frías, Óscar ; Tella, José L. ; Møller, Anders P ; Figuerola, Jordi ; Pap, Peter L: ; Kovács, István ; Vágási, Csongor I. ; Meléndez, Leandro ; Blanco, Guillermo ; Aguilera, Eduardo ; Senar, Juan Carlos ; Galván, Ismael ; Atiénzar, Francisco ; Barba, Emilio ; Cantó, José L. ; Cortés, Verónica ; Monrós, Juan S. ; Piculo, Rubén ; Vögeli, Matthias ; Borrás, Antoni ; Navarro, Carlos ; Mestre, Alexandre ; Jovani, Roger | Public Library of Science | 2014-09-12Understanding why host species differ so much in symbiont loads and how this depends on ecological host and symbiont traits is a major issue in the ecology of symbiosis. A first step in this inquiry is to know whether observed differences among [...]![]()
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Kocher, Claudine ; Morrison, Amy-C. ; Leguia, Mariana ; Loyola, Steev ; Castillo, Roger-M. ; Galvez, Hugo-A. ; Astete, Helvio ; Flores-Mendoza, Carmen ; Ampuero, Julia-S. ; Bausch, Daniel-G. ; Halsey, Eric-S. ; Cespedes, Manuel ; Zevallos, Karine ; Jiang, Ju ; Richards, Allen-L. | Public Library of Science | 2019-02-06T14:45:36ZUsing a large, passive, clinic-based surveillance program in Iquitos, Peru, we characterized the prevalence of rickettsial infections among undifferentiated febrile cases and obtained evidence of pathogen transmission in potential domestic reser[...]![]()
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O'Neal, Seth E. ; Moyano, Luz M. ; Ayvar, Viterbo ; Rodriguez, Silvia ; Gavidia, Cesar ; Wilkins, Patricia P. ; Gilman, Robert H. ; Garcia, Hector H. ; Gonzalez, Armando E. | Public Library of Science | 2020-06-10T18:12:17ZBACKGROUND: Taenia solium is a major cause of preventable epilepsy in developing nations. Screening and treatment of human intestinal stage infection (taeniasis) within high-risk foci may reduce transmission and prevent epilepsy by limiting hu[...]![]()
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Park, Hayoung ; Konda, Kelika-A. ; Roberts, Chelsea-P. ; Maguina, Jorge-L. ; Leon, Segundo-R. ; Clark, Jesse-L. ; Coates, Thomas-J. ; Caceres, Carlos-F. ; Klausner, Jeffrey-D. | Public Library of Science | 2019-02-06T14:45:57ZBACKGROUND: Syphilis is concentrated among high-risk groups, but the epidemiology of syphilis reinfection is poorly understood. We characterized factors associated with syphilis incidence, including reinfection, in a high-risk cohort in Peru. ME[...]![]()
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Lambert, Allison A. ; Lam, Jennifer O. ; Paik, Julie J. ; Ugarte-Gil, Cesar ; Drummond, M. Bradley ; Crowell, Trevor A. | Public Library of Science | 2019-02-06T14:53:10ZBACKGROUND: Proton-pump inhibitors (PPIs) are among the most frequently prescribed medications. Community-acquired pneumonia (CAP) is a common cause of morbidity, mortality and healthcare spending. Some studies suggest an increased risk of CAP a[...]![]()
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Ramírez, J.D. ; Sordillo, E.M. ; Gotuzzo, E. ; Zavaleta, C. ; Caplivski, D. ; Navarro, J.C. ; Crainey, J.L. ; Luz, S.L.B. ; Delgado Noguera, L.A. ; Schaub, R. ; Rousseau, C. ; Herrera, G. ; Oliveira-Miranda, M.A. ; Quispe-Vargas, M.T. ; Hotez, P.J. ; Mondolfi, A.P. | Public Library of Science | 2020-12-14T16:10:06ZAs the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) pandemic contin-ues to expand, healthcare resources globally have been spread thin. Now, the disease is rapidly spreading across South America, with deadly consequences in areas[...]![]()
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Zafra-Tanaka, Jessica Hanae ; Hurtado-Villanueva, Marcia Esther ; Saenz-Naranjo, María Del Pilar ; Taype-Rondan, Álvaro | Public Library of Science | 2018-11-30T22:50:37ZOBJECTIVE: To assess the prevalence of recently graduated physicians who perceived themselves as adequately competent to perform Papanicolaou (PAP), Visual Inspection with Acetic Acid (VIA), and Visual Inspection with Lugol´s Iodine (VILI); and [...]![]()
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Berry, A.S.F. ; Salazar-Sánchez, R. ; Castillo-Neyra, R. ; Borrini-Mayorí, K. ; Chipana-Ramos, C. ; Vargas-Maquera, M. ; Ancca-Juarez, J. ; Náquira-Velarde, C. ; Levy, M.Z. ; Brisson, D. ; Chagas Disease Working Group in Arequipa | Public Library of Science | 2019-12-06T21:04:41ZBackground Sexual reproduction provides an evolutionary advantageous mechanism that combines favorable mutations that have arisen in separate lineages into the same individual. This advantage is especially pronounced in microparasites as allelic[...]![]()
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Berry, Alexander S. F. ; Salazar-Sanchez, Renzo ; Castillo-Neyra, Ricardo ; Borrini-Mayori, Katty ; Chipana-Ramos, Claudia ; Vargas-Maquera, Melina ; Ancca-Juarez, Jenny ; Naquira-Velarde, Cesar ; Levy, Michael Z. ; Brisson, Dustin | Public Library of Science | 2019-07-04T17:00:24ZBACKGROUND: Sexual reproduction provides an evolutionary advantageous mechanism that combines favorable mutations that have arisen in separate lineages into the same individual. This advantage is especially pronounced in microparasites as allel[...]![]()
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Carrillo-Larco, Rodrigo M. ; Bernabé-Ortiz, Antonio ; Miranda, J. Jaime | Public Library of Science | 2020-06-10T18:12:20ZBACKGROUND: We aimed to describe the patterns of nutritional status and sleep duration in children from Ethiopia, India, Peru and Vietnam; to assess the association between short sleep duration and overweight and obesity, and if this was simila[...]![]()
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Aya Pastrana, Nathaly ; Lazo-Porras, Maria ; Miranda, J. Jaime ; Beran, David ; Suggs, L. Suzanne | Public Library of Science | 2020-07-14T00:00:55ZBACKGROUND: Social marketing is an approach to behavior change that contributes to disease prevention and control. This study aimed to understand how social marketing interventions have addressed neglected tropical diseases (NTDs). It examined t[...]![]()
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Castillo-Neyra, Ricardo ; Toledo, Amparo M. ; Arevalo-Nieto, Claudia ; MacDonald, Hannelore ; De la Puente-Leon, Micaela ; Naquira-Velarde, Cesar ; Paz-Soldan, Valerie A. ; Buttenheim, Alison M. ; Levy, Michael Z. | Public Library of Science | 2019-12-06T21:04:42ZTo control and prevent rabies in Latin America, mass dog vaccination campaigns (MDVC) are implemented mainly through fixed-location vaccination points: owners have to bring their dogs to the vaccination points where they receive the vaccination [...]![]()
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Castillo-Neyra, Ricardo ; Toledo, Amparo M. ; Arevalo-Nieto, Claudia ; MacDonald, Hannelore ; De la Puente-Leon, Micaela ; Naquira-Velarde, Cesar ; Paz-Soldan, Valerie A. ; Buttenheim, Alison M. ; Levy, Michael Z. | Public Library of Science | 2019-08-08T15:23:47ZTo control and prevent rabies in Latin America, mass dog vaccination campaigns (MDVC) are implemented mainly through fixed-location vaccination points: owners have to bring their dogs to the vaccination points where they receive the vaccination [...]![]()
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Quinto-Sanchez, Mirsha ; Cintas, Celia ; Silva de Cerqueira, Caio Cesar ; Ramallo, Virginia ; Acuna-Alonzo, Victor ; Adhikari, Kaustubh ; Castillo, Lucia ; Gomez-Valdes, Jorge ; Everardo, Paola ; de Avila, Francisco ; Hunemeier, Tabita ; Jaramillo, Claudia ; Arias, Williams ; Fuentes, Macarena ; Gallo, Carla ; Poletti, Giovani ; Schuler-Faccini, Lavinia ; Bortolini, Maria Catira ; Canizales-Quinteros, Samuel ; Rothhammer, Francisco ; Bedoya, Gabriel ; Rosique, Javier ; Ruiz-Linares, Andrés ; González-José, Rolando | Public Library of Science | 2019-01-25T16:03:20ZThe expression of facial asymmetries has been recurrently related with poverty and/or disadvantaged socioeconomic status. Departing from the developmental instability theory, previous approaches attempted to test the statistical relationship bet[...]![]()
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Pray, Ian W. ; Ayvar, Viterbo ; Gamboa, Ricardo ; Muro, Claudio ; Moyano, Luz M. ; Benavides, Victor ; Flecker, Robert H. ; Garcia, Hector H. ; O'Neal, Seth E. | Public Library of Science | 2019-01-25T16:03:20ZBACKGROUND: Taenia solium, a parasite that affects humans and pigs, is the leading cause of preventable epilepsy in the developing world. Geographic hotspots of pigs testing positive for serologic markers of T. solium exposure have been observed[...]