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Título:
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In vitro evaluation of a soluble Leishmania promastigote surface antigen as a potential vaccine candidate against human leishmaniasis
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Autores:
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Chamakh-Ayari, Rym ;
Bras-Gonçalves, Rachel ;
Bahi-Jaber, Narges ;
Petitdidier, Elodie ;
Markikou-Ouni, Wafa ;
Aoun, Karim ;
Moreno, Javier ;
Carrillo, Eugenia ;
Salotra, Poonam ;
Kaushal, Himanshu ;
Negi, Narender Singh ;
Arevalo, Jorge ;
Falconi-Agapito, Francesca ;
Privat, Angela ;
Cruz, Maria ;
Pagniez, Julie ;
Papierok, Gerard-Marie ;
Rhouma, Faten Bel Haj ;
Torres, Pilar ;
Lemesre, Jean-Loup ;
Chenik, Mehdi ;
Meddeb-Garnaoui, Amel
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Tipo de documento:
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texto impreso
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Editorial:
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Public Library of Science, 2020-06-10T18:12:17Z
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Nota general:
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info:eu-repo/semantics/restrictedAccess
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
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Idiomas:
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Inglés
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Palabras clave:
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Editados por otras instituciones
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Artículos
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Artículos en revistas indizadas
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Resumen:
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PSA (Promastigote Surface Antigen) belongs to a family of membrane-bound and secreted proteins present in several Leishmania (L.) species. PSA is recognized by human Th1 cells and provides a high degree of protection in vaccinated mice. We evaluated humoral and cellular immune responses induced by a L. amazonensis PSA protein (LaPSA-38S) produced in a L. tarentolae expression system. This was done in individuals cured of cutaneous leishmaniasis due to L. major (CCLm) or L. braziliensis (CCLb) or visceral leishmaniasis due to L. donovani (CVLd) and in healthy individuals. Healthy individuals were subdivided into immune (HHR-Lm and
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En línea:
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http://doi.org/10.1371/journal.pone.0092708
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