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Título:
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Effect of low-sodium salt substitutes on blood pressure, detected hypertension, stroke and mortality
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Autores:
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Hernandez, Adrian V. ;
Emonds, Erin E. ;
Chen, Brett A. ;
Zavala-Loayza, Alfredo J. ;
Thota, Priyaleela ;
Pasupuleti, Vinay ;
Roman, Yuani M. ;
Bernabé-Ortiz, Antonio ;
Miranda, J. Jaime
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Tipo de documento:
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texto impreso
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Editorial:
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BMJ Publishing Group, 2019-07-04T16:59:31Z
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Nota general:
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info:eu-repo/semantics/restrictedAccess
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
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Idiomas:
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Inglés
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Palabras clave:
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Editados por otras instituciones
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Artículos
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Artículos en revistas indizadas
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Resumen:
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OBJECTIVE: A systematic review and meta-analysis was conducted to assess the efficacy of low-sodium salt substitutes (LSSS) as a potential intervention to reduce cardiovascular (CV) diseases. METHODS: Five engines and ClinicalTrials.gov were searched from inception to May 2018. Randomised controlled trials (RCTs) enrolling adult hypertensive or general populations that compared detected hypertension, systolic blood pressure (SBP), diastolic blood pressure (DBP), overall mortality, stroke and other CV risk factors in those receiving LSSS versus regular salt were included. Effects were expressed as risk ratios or mean differences (MD) and their 95% CIs. Quality of evidence assessment followed GRADE (Grading of Recommendations Assessment, Development and Evaluation) methodology. RESULTS: 21 RCTs (15 in hypertensive (n=2016), 2 in normotensive (n=163) and 4 in mixed populations (n=5224)) were evaluated. LSSS formulations were heterogeneous. Effects were similar across hypertensive, normotensive and mixed populations. LSSS decreased SBP (MD -7.81 mm Hg, 95% CI -9.47 to -6.15, p
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En línea:
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http://doi.org/10.1136/heartjnl-2018-314036
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