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Hurtado, J. ; Pacheco, S.L. ; Sheen, P. ; Ugarte, D. | Slovak University of Agriculture in Nitra, Faculty of Biotechnology and Food Sciences | 2018-11-30T23:41:31ZA total of twenty-four isolates of actinobacteria from arsenopyrite, pyrite, polymetallic sulfides and magnetite from Peruvian mining zones have been used with the purpose of characterizing them by morphological, physiological and molecular stud[...]texto impreso
Ramos-Sono, D. ; Laureano, R. ; Rueda, D. ; Gilman, R.H. ; Rosa, A.L. ; Ruiz, J. ; León, R. ; Sheen, P. ; Zimic, M. | Public Library of Science | 2020-12-14T16:10:06ZTuberculosis (TB) is a major global public health problem with high mortality and morbidity. In low-middle income countries (LMIC) a large number of respiratory symptomatic cases that require TB screening per year demands more accurate, fast and[...]texto impreso
Tuberculosis is an infectious disease that causes ill health and death in millions of people each year worldwide. Timely diagnosis and treatment is key to full patient recovery. The Microscopic Observed Drug Susceptibility (MODS) is a test to di[...]texto impreso
Lopez, J.M. ; Antiparra, R. ; lippens, G. ; Zimic, M. ; Sheen, P. ; Maruenda, H. | Springer | 2019-12-06T21:04:50ZChagas disease is a trypanosomiasis disease inflicted by Trypanosoma cruzi parasite. In Latin America, at least 10 million people are infected and annually, 10,000 casualties are deplored. Macrophage infectivity potentiator protein is one of the[...]texto impreso
León-Janampa, N. ; Liendo, R. ; Gilman, R.H. ; Padilla, C. ; Garcia, H.H. ; Gonzales, A. ; Sheen, P. ; Pajuelo, M.J. ; Zimic, M. ; for the Cysticercosis Working Group in Peru | Elsevier | 2019-12-06T21:02:57ZPorcine cysticercosis is an endemic parasitic disease caused by infection with Taenia solium that is found predominantly in developing countries. In order to aid in the development of simple diagnostic approaches, identification and characteriza[...]texto impreso
Vargas, A. ; Ríos, A. ; Grandjean, L. ; Kirwan, D. ; Gilman, R. ; Sheen, P. ; Zimic, M. | Wolters Kluwer Medknow Publications | 2020-12-14T16:11:07ZBackground: Rifampicin (RIF) resistance in Mycobacterium tuberculosis is frequently caused by mutations in the rpoB gene. These mutations are associated with a fitness cost, which can be overcome by compensatory mutations in other genes, among w[...]texto impreso
Coronel, J.E. ; Del Carpio, C.C. ; Dianderas, E.J. ; Florentini, E.A. ; Kemper, G.L. ; Sheen, P. ; Zimic, M.J. | Medknow Publications | 2019-12-06T21:04:42ZBackground: Direct sputum smear is still the first-choice tool for screening of tuberculosis worldwide. Variants of this technique, to improve the sensitivity are desired. Methods: Two microbiological variants of the standard sputum smear ('pell[...]texto impreso
Florentini, E.A. ; Angulo, N. ; Gilman, R.H. ; Alcántara, R. ; Roncal, E. ; Antiparra, R. ; Toscano, E. ; Vallejos, K. ; Kirwan, D. ; Zimic, M. ; Sheen, P. | Public Library of Science | 2020-12-14T16:06:23ZPyrazinamide (PZA) susceptibility testing in Mycobacterium tuberculosis (Mtb) is a current area of development and PZA-resistant strains are increasingly prevalent. Previous studies have demonstrated that the detection of pyrazinoic acid (POA), [...]texto impreso
Sheen, P. ; Monsalve, A. ; Campos, J. ; Huerta, R. ; Antiparra, R. ; Arteaga, H. ; Duran, P. ; Bueno, C. ; Kirwan, D.E. ; Gilman, R.H. ; Zimic, M. | American Society for Microbiology | 2020-12-14T16:10:13ZMycobacterium tuberculosis nicotinamidase-pyrazinamidase (PZAse) is a metalloenzyme that catalyzes conversion of nicotinamide-pyrazinamide to nicotinic acid-pyrazinoic acid. This study investigated whether a metallochaperone is required for opti[...]texto impreso
Alcántara, R. ; Fuentes, P. ; Antiparra, R. ; Santos, M. ; Gilman, R.H. ; Kirwan, D.E. ; Zimic, M. ; Sheen, P. | American Society for Microbiology | 2019-12-06T21:02:57ZAlthough pyrazinamide (PZA) is a key component of first- and second-line tuberculosis treatment regimens, there is no gold standard to determine PZA resistance. Approximately 50% of multidrug-resistant tuberculosis (MDR-TB) and over 90% of exten[...]texto impreso
Muehlig, A. ; Jahn, I.J. ; Heidler, J. ; Jahn, M. ; Weber, K. ; Sheen, P. ; Zimic, M. ; Cialla-May, D. ; Popp, J. | MDPI | 2019-12-06T21:04:48ZThe prodrug pyrazinamide (PZA) is metabolized by the mycobacteria to pyrazinoic acid (POA), which is expelled into the extracellular environment. PZA resistance is highly associated to a lack of POA efflux. Thus, by detecting a reduction of the [...]texto impreso
Muehlig, A. ; Jahn, I.J. ; Heidler, J. ; Jahn, M. ; Weber, K. ; Sheen, P. ; Zimic, M. ; Cialla-May, D. ; Popp, J. | MDPI | 2019-08-08T15:23:44ZThe prodrug pyrazinamide (PZA) is metabolized by the mycobacteria to pyrazinoic acid (POA), which is expelled into the extracellular environment. PZA resistance is highly associated to a lack of POA efflux. Thus, by detecting a reduction of the [...]texto impreso
Vallejos-Sánchez, K. ; Lopez, J.M. ; Antiparra, R. ; Toscano, E. ; Saavedra, H. ; Kirwan, D.E. ; Amzel, L.M. ; Gilman, R.H. ; Maruenda, H. ; Sheen, P. ; Zimic, M. | Nature Research | 2020-12-14T16:10:22ZPyrazinamide (PZA) is an antibiotic used in first- and second-line tuberculosis treatment regimens. Approximately 50% of multidrug-resistant tuberculosis and over 90% of extensively drug-resistant tuberculosis strains are also PZA resistant. Des[...]texto impreso
Dianderas, E. ; Del Carpio, C. ; Zimic, M. ; Sheen, P. ; Coronel, J. ; Lavarello, R. ; Kemper, G. | Institute of Advanced Engineering and Science | 2020-12-14T16:06:20ZThis work proposes an algorithm aimed at recognizing and accounting Koch bacilli in digital images of microbiological sputum samples stained with auramine, in order to determine the degree of concentration and the state of the disease (tuberculo[...]texto impreso
Supo-Escalante, R.R. ; Médico, A. ; Gushiken, E. ; Olivos-Ramírez, G.E. ; Quispe, Y. ; Torres, F. ; Zamudio, M. ; Antiparra, R. ; Mario Amzel, L. ; Gilman, R.H. ; Sheen, P. ; Zimic, M. | Public Library of Science | 2020-12-14T16:10:16ZBackground: Pyrazinamide is an important drug against the latent stage of tuberculosis and is used in both first- and second-line treatment regimens. Pyrazinamide-susceptibility test usually takes a week to have a diagnosis to guide initial ther[...]
