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Montalvo, Raúl ; Bernabé-Ortiz, Antonio ; Kirwan, Daniela E. ; Gilman, Robert H. | African Traditional Herbal Medicine Supporters Initiative | 2018-11-30T02:09:30ZBackground: The changes in body composition markers (weight, fat mass, lean mass, and BMI) over time can be associated with TB treatment outcome among HIV-infected patients. The aim of this study was to investigate whether changes in fat mass an[...]texto impreso
Dudley, Matthew Z. ; Sheen, Patricia ; Gilman, Robert H. ; Ticona, Eduardo ; Friedland, Jon S. ; Kirwan, Daniela E. ; Caviedes, Luz ; Rodriguez, Richard ; Cabrera, Lilia Z. ; Coronel, Jorge ; Grandjean, Louis ; Moore, David A. J. ; Evans, Carlton A. ; Huaroto, Luz ; Chavez-Perez, Victor ; Zimic, Mirko | American Society of Tropical Medicine and Hygiene | 2019-02-06T14:45:12ZHospital infection control measures are crucial to tuberculosis (TB) control strategies within settings caring for human immunodeficiency virus (HIV)-positive patients, as these patients are at heightened risk of developing TB. Pyrazinamide (PZA[...]texto impreso
Alcántara, Roberto ; Fuentes, Patricia ; Marin, Lisette ; Kirwan, Daniela E. ; Gilman, Robert H. ; Zimic, Mirko ; Sheen, Patricia | American Society for Microbiology | 2020-07-14T00:00:54ZPyrazinamide (PZA) is considered the pivot drug in all tuberculosis treatment regimens, due to its particular action on the persistent forms of Mycobacterium tuberculosis. However, no drug susceptibility test (DST) is considered sufficiently rel[...]texto impreso
Proaño, Alvaro ; Bravard, Marjory A. ; López, José W. ; Lee, Gwenyth O. ; Bui, David ; Datta, Sumona ; Comina, Germán ; Zimic, Mirko ; Coronel, Jorge ; Caviedes, Luz ; Cabrera, Jose L. ; Salas, Antonio ; Ticona, Eduardo ; Vu, Nancy M. ; Kirwan, Daniela E. ; Loader, Maria-Cristina I. ; Friedland, Jon S. ; Moore, David A. J. ; Evans, Carlton A. ; Tracey, Brian H. ; Gilman, Robert H. | Oxford University Press | 2019-01-25T16:59:37ZBackground: Cough is the major determinant of tuberculosis transmission. Despite this, there is a paucity of information regarding characteristics of cough frequency throughout the day and in response to tuberculosis therapy. Here we evaluate th[...]texto impreso
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Kirwan, Daniela E. ; Ugarte-Gil, Cesar ; Gilman, Robert H. ; Hasan Rizvi, Syed M. ; Cerrillo, Gustavo ; Cok, Jaime ; Ticona, Eduardo ; Cabrera, Jose Luis ; Matos, Eduardo D. ; Evans, Carlton A. ; Moore, David A. J. ; Friedland, Jon S. ; Lymph Node Tuberculosis Working Group | American Society of Tropical Medicine and Hygiene | 2019-01-25T15:18:36ZThe differential diagnosis for lymphadenopathy is wide and clinical presentations overlap, making obtaining an accurate diagnosis challenging. We sought to characterize the clinical and radiological characteristics, histological findings, and di[...]texto impreso
Ticona, Eduardo ; Huaroto, Luz ; Kirwan, Daniela E. ; Chumpitaz, Milagros ; Munayco, Cesar V. ; Maguina, Monica ; Tovar, Marco A. ; Evans, Carlton A. ; Escombe, Roderick ; Gilman, Robert H. | American Society of Tropical Medicine and Hygiene | 2019-02-06T14:48:07ZMultidrug-resistant tuberculosis (MDRTB) rates in a human immunodeficiency virus (HIV) care facility increased by the year 2000-56% of TB cases, eight times the national MDRTB rate. We reported the effect of tuberculosis infection control measu[...]texto impreso
Ugarte-Gil, Cesar ; Carrillo-Larco, Rodrigo M. ; Kirwan, Daniela E. | Elsevier | 2019-07-04T17:00:17ZThe prevalence of non-communicable diseases is increasing worldwide, which coincides with the persistence of infectious diseases including tuberculosis. These can synergistically affect individual and population health. Three non-communicable di[...]texto impreso
Kirwan, Daniela E. ; Ugarte-Gil, Cesar ; Gilman, Robert H. ; Caviedes, Luz ; Rizvi, Hasan ; Ticona, Eduardo ; Chavez, Gonzalo ; Cabrera, Jose Luis ; Matos, Eduardo D. ; Evans, Carlton A. ; Moore, David A. J. ; Friedland, Jon S. ; Lymph Node TB Working Group | American Society for Microbiology | 2019-02-06T14:52:38ZIn this study, 132 patients with lymphadenopathy were investigated. Fifty-two (39.4%) were diagnosed with tuberculosis (TB). The microscopic observation drug susceptibility (MODS) assay provided rapid (13 days), accurate diagnosis (sensitivity, [...]texto impreso
Alcántara, Roberto ; Fuentes, Patricia ; Antiparra, Ricardo ; Santos, Marco ; Gilman, Robert H. ; Kirwan, Daniela E. ; Zimic, Mirko ; Sheen, Patricia | American Society for Microbiology | 2018-11-30T17:17:15ZAlthough pyrazinamide (PZA) is a key component of first and second line tuberculosis treatment regimens, there is no gold standard to determine PZA resistance. Approximately 50% of multidrug-resistant tuberculosis (MDR-TB) and over 90% of extens[...]texto impreso
Fox, Katharine A. ; Kirwan, Daniela E. ; Whittington, Ashley M. ; Krishnan, Nitya ; Robertson, Brian D. ; Gilman, Robert H. ; López, José W. ; Singh, Shivani ; Porter, Joanna C. ; Friedland, Jon S. | American Thoracic Society | 2018-11-30T22:50:35ZRATIONALE: Platelets may interact with the immune system in tuberculosis (TB) to regulate human inflammatory responses that lead to morbidity and spread of infection. OBJECTIVES: To identify a functional role of platelets in the innate inflammat[...]texto impreso
Proaño, Alvaro ; Bravard, Marjory A. ; Tracey, Brian H. ; López, José W. ; Comina, Germán ; Zimic, Mirko ; Coronel, Jorge ; Lee, Gwenyth O'Neil ; Caviedes, Luz ; Cabrera, Jose Luis ; Salas, Antonio ; Ticona, Eduardo ; Kirwan, Daniela E. ; Friedland, Jon S. ; Evans, Carlton A. ; Moore, David A. ; Gilman, Robert H. | BMJ Publishing Group | 2019-02-06T14:51:43ZINTRODUCTION: Cough is a key symptom of tuberculosis (TB) as well as the main cause of transmission. However, a recent literature review found that cough frequency (number of coughs per hour) in patients with TB has only been studied once, in 19[...]texto impreso
Paris, Luisa ; Magni, Ruben ; Zaidi, Fatima ; Araujo, Robyn ; Saini, Neal ; Harpole, Michael ; Coronel, Jorge ; Kirwan, Daniela E. ; Steinberg, Hannah ; Gilman, Robert H. ; Petricoin, Emanuel F. ; Nisini, Roberto ; Luchini, Alessandra ; Liotta, Lance | American Association for the Advancement of Sience | 2019-01-25T16:20:55ZAn accurate urine test for pulmonary tuberculosis (TB), affecting 9.6 million patients worldwide, is critically needed for surveillance and treatment management. Past attempts failed to reliably detect the mycobacterial glycan antigen lipoarabin[...]
