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Título:
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Highs and lows of sympathetic neurocardiovascular transduction: influence of altitude acclimatization and adaptation
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Autores:
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Berthelsen, L.F. ;
Fraser, G.M. ;
Simpson, L.L. ;
Vanden Berg, E.R. ;
Busch, S.A. ;
Steele, A.R. ;
Meah, V.L. ;
Lawley, J.S. ;
Figueroa-Mujíca, R.J. ;
Vizcardo-Galindo, G. ;
Villafuerte, F. ;
Gasho, C. ;
Willie, C.K. ;
Tymko, M.M. ;
Ainslie, P.N. ;
Stembridge, M. ;
Moore, J.P. ;
Steinback, C.D.
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Tipo de documento:
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texto impreso
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Editorial:
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NLM (Medline), 2020-12-14T16:06:09Z
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Nota general:
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info:eu-repo/semantics/restrictedAccess
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
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Idiomas:
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Inglés
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Palabras clave:
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Editados por otras instituciones
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Artículos
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Artículos en revistas indizadas
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Resumen:
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High-altitude (>2,500 m) exposure results in increased muscle sympathetic nervous activity (MSNA) in acclimatizing lowlanders. However, little is known about how altitude affects MSNA in indigenous high-altitude populations. Additionally, the relationship between MSNA and blood pressure regulation (i.e., neurovascular transduction) at high-altitude is unclear. We sought to determine 1) how high-altitude effects neurocardiovascular transduction and 2) whether differences exist in neurocardiovascular transduction between low- and high-altitude populations. Measurements of MSNA (microneurography), mean arterial blood pressure (MAP; finger photoplethysmography), and heart rate (electrocardiogram) were collected in 1) lowlanders (n = 14) at low (344 m) and high altitude (5,050 m), 2) Sherpa highlanders (n = 8; 5,050 m), and 3) Andean (with and without excessive erythrocytosis) highlanders (n = 15; 4,300 m). Cardiovascular responses to MSNA burst sequences (i.e., singlet, couplet, triplet, and quadruplet) were quantified using custom software (coded in MATLAB, v.2015b). Slopes were generated for each individual based on peak responses and normalized total MSNA. High altitude reduced neurocardiovascular transduction in lowlanders (MAP slope: high altitude, 0.0075?±?0.0060 vs. low altitude, 0.0134?±?0.080; P = 0.03). Transduction was elevated in Sherpa (MAP slope, 0.012?±?0.007) compared with Andeans (0.003?± 0.002, P = 0.001). MAP transduction was not statistically different between acclimatizing lowlanders and Sherpa (MAP slope, P = 0.08) or Andeans (MAP slope, P = 0.07). When resting MSNA is accounted for (ANCOVA), transduction was inversely related to basal MSNA (bursts/minute) independent of population (RRI, r?=?0.578 P
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En línea:
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http://repositorio.upch.edu.pe/handle/upch/8668
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