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Autor Sheen, Patricia |
Documentos disponibles escritos por este autor (22)
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Lopez-Garnier, Santiago ; Sheen, Patricia ; Zimic, Mirko | Public Library of Science | 2019-07-04T16:59:21ZTuberculosis is an infectious disease that causes ill health and death in millions of people each year worldwide. Timely diagnosis and treatment is key to full patient recovery. The Microscopic Observed Drug Susceptibility (MODS) is a test to d[...]![]()
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Lopez, Juan M. ; Antiparra, Ricardo ; Lippens, Guy ; Zimic, Mirko ; Sheen, Patricia ; Maruenda, Helena | Springer | 2018-11-30T02:09:30ZChagas disease is a trypanosomiasis disease inflicted by Trypanosoma cruzi parasite. In Latin America, at least 10 million people are infected and annually, 10,000 casualties are deplored. Macrophage infectivity potentiator protein is one of the[...]![]()
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León-Janampa, Nancy ; Liendo, Ruddy ; Gilman, Robert H. ; Padilla, Carlos ; Garcia, Hector H. ; Gonzales, Armando ; Sheen, Patricia ; Pajuelo, Monica J. ; Zimic, Mirko ; Cysticercosis Working Group in Peru | Elsevier | 2019-07-04T16:59:24ZPorcine cysticercosis is an endemic parasitic disease caused by infection with Taenia solium that is found predominantly in developing countries. In order to aid in the development of simple diagnostic approaches, identification and characteriza[...]![]()
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Dudley, Matthew Z. ; Sheen, Patricia ; Gilman, Robert H. ; Ticona, Eduardo ; Friedland, Jon S. ; Kirwan, Daniela E. ; Caviedes, Luz ; Rodriguez, Richard ; Cabrera, Lilia Z. ; Coronel, Jorge ; Grandjean, Louis ; Moore, David A. J. ; Evans, Carlton A. ; Huaroto, Luz ; Chavez-Perez, Victor ; Zimic, Mirko | American Society of Tropical Medicine and Hygiene | 2019-02-06T14:45:12ZHospital infection control measures are crucial to tuberculosis (TB) control strategies within settings caring for human immunodeficiency virus (HIV)-positive patients, as these patients are at heightened risk of developing TB. Pyrazinamide (PZA[...]![]()
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Alcántara, Roberto ; Fuentes, Patricia ; Marin, Lisette ; Kirwan, Daniela E. ; Gilman, Robert H. ; Zimic, Mirko ; Sheen, Patricia | American Society for Microbiology | 2020-07-14T00:00:54ZPyrazinamide (PZA) is considered the pivot drug in all tuberculosis treatment regimens, due to its particular action on the persistent forms of Mycobacterium tuberculosis. However, no drug susceptibility test (DST) is considered sufficiently rel[...]![]()
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Solis, Leonardo ; Coronel, Jorge ; Rueda, Daniel ; Gilman, Robert H. ; Sheen, Patricia ; Zimic, Mirko | Elsevier | 2019-02-06T14:57:42ZTuberculosis (TB) control efforts are hampered by a mismatch in diagnostic technology. Lack of adequate early diagnostics and Multi-drug resistant (MDR) detection is a critical problem in control efforts. Alternate and novel diagnostic approache[...]![]()
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Coronel, Jorge E. ; Del Carpio, Christian C. ; Dianderas, Erwin J. ; Florentini, Edgar A. ; Kemper, Guillermo L. ; Sheen, Patricia ; Zimic, Mirko J. | Medknow Publications | 2019-07-04T16:59:33ZBackground: Direct sputum smear is still the first-choice tool for screening of tuberculosis worldwide. Variants of this technique, to improve the sensitivity are desired. Methods: Two microbiological variants of the standard sputum smear ("pell[...]![]()
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Pajuelo, Monica J. ; Eguiluz, María ; Roncal, Elisa ; Quiñones-García, Stefany ; Clipman, Steven J. ; Calcina, Juan ; Gavidia, Cesar M. ; Sheen, Patricia ; Garcia, Hector H. ; Gilman, Robert H. ; Gonzalez, Armando E. ; Zimic, Mirko ; Cysticercosis Working Group in Peru | Public Library of Science | 2019-01-25T15:18:36ZThe adult Taenia solium, the pork tapeworm, usually lives as a single worm in the small intestine of humans, its only known definitive host. Mechanisms of genetic variation in T. solium are poorly understood. Using three microsatellite markers p[...]![]()
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Coll, Francesc ; Phelan, Jody ; Hill-Cawthorne, Grant A. ; Nair, Mridul B. ; Mallard, Kim ; Ali, Shahjahan ; Abdallah, Abdallah M. ; Alghamdi, Saad ; Alsomali, Mona ; Ahmed, Abdallah O. ; Portelli, Stephanie ; Oppong, Yaa ; Alves, Adriana ; Bessa, Theolis Barbosa ; Campino, Susana ; Caws, Maxine ; Chatterjee, Anirvan ; Crampin, Amelia C. ; Dheda, Keertan ; Furnham, Nicholas ; Glynn, Judith R. ; Grandjean, Louis ; Minh Ha, Dang ; Hasan, Rumina ; Hasan, Zahra ; Hibberd, Martin L. ; Joloba, Moses ; Jones-López, Edward C. ; Matsumoto, Tomoshige ; Miranda, Anabela ; Moore, David J. ; Mocillo, Nora ; Panaiotov, Stefan ; Parkhill, Julian ; Penha, Carlos ; Perdigão, João ; Portugal, Isabel ; Rchiad, Zineb ; Robledo, Jaime ; Sheen, Patricia ; Shesha, Nashwa Talaat ; Sirgel, Frik A. ; Sola, Christophe ; Oliveira Sousa, Erivelton ; Streicher, Elizabeth M. ; Helden, Paul Van ; Viveiros, Miguel ; Warren, Robert M. ; McNerney, Ruth ; Pain, Arnab ; Clark, Taane G. | Nature Research | 2018-11-30T03:10:47ZTo characterize the genetic determinants of resistance to antituberculosis drugs, we performed a genome-wide association study (GWAS) of 6,465 Mycobacterium tuberculosis clinical isolates from more than 30 countries. A GWAS approach within a mix[...]![]()
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Pajuelo, Monica J. ; Eguiluz, María ; Dahlstrom, Eric ; Requena, David ; Guzman, Frank ; Ramírez, Manuel ; Sheen, Patricia ; Frace, Michael ; Sammons, Scott ; Cama, Vitaliano ; Anzick, Sarah ; Bruno, Dan ; Mahanty, Siddhartha ; Wilkins, Patricia ; Nash, Theodore ; Gonzalez, Armando ; Garcia, Hector H. ; Gilman, Robert H. ; Porcella, Steve ; Zimic, Mirko | Public Library of Science | 2019-02-06T14:53:08ZBACKGROUND: Infections with Taenia solium are the most common cause of adult acquired seizures worldwide, and are the leading cause of epilepsy in developing countries. A better understanding of the genetic diversity of T. solium will improve p[...]![]()
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Warren, Joshua L. ; Grandjean, Louis ; Moore, David A. J. ; Lithgow, Anna ; Coronel, Jorge ; Sheen, Patricia ; Zelner, Jonathan L. ; Andrews, Jason R. ; Cohen, Ted | BMC | 2018-11-30T17:17:14ZBACKGROUND: Congregate settings may serve as institutional amplifiers of tuberculosis (TB) and multidrug-resistant tuberculosis (MDR-TB). We analyze spatial, epidemiological, and pathogen genetic data prospectively collected from neighborhoods s[...]![]()
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Alva, Alicia ; Cangalaya, Carla ; Quiliano, Miguel ; Krebs, Casey ; Gilman, Robert H. ; Sheen, Patricia ; Zimic, Mirko | Public Library of Science | 2019-01-25T15:28:05ZParasitic infections are generally diagnosed by professionals trained to recognize the morphological characteristics of the eggs in microscopic images of fecal smears. However, this laboratory diagnosis requires medical specialists which are lac[...]![]()
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Salazar-Salinas, Karim ; Baldera-Aguayo, Pedro A. ; Encomendero-Risco, Jimy J. ; Orihuela, Melvin ; Sheen, Patricia ; Seminario, Jorge M. ; Zimic, Mirko | American Chemical Society | 2020-06-10T18:12:14ZMycobacterium tuberculosis pyrazinamidase (PZAse) is a key enzyme to activate the pro-drug pyrazinamide (PZA). PZAse is a metalloenzyme that coordinates in vitro different divalent metal cofactors in the metal coordination site (MCS). Several m[...]![]()
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Alcántara, Roberto ; Fuentes, Patricia ; Antiparra, Ricardo ; Santos, Marco ; Gilman, Robert H. ; Kirwan, Daniela E. ; Zimic, Mirko ; Sheen, Patricia | American Society for Microbiology | 2018-11-30T17:17:15ZAlthough pyrazinamide (PZA) is a key component of first and second line tuberculosis treatment regimens, there is no gold standard to determine PZA resistance. Approximately 50% of multidrug-resistant tuberculosis (MDR-TB) and over 90% of extens[...]![]()
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Sheen, Patricia ; Requena, David ; Gushiken, Eduardo ; Gilman, Robert H. ; Antiparra, Ricardo ; Lucero, Bryan ; Lizárraga, Pilar ; Cieza, Basilio ; Roncal, Elisa ; Grandjean, Louis ; Pain, Arnab ; McNerney, Ruth ; Clark, Taane G. ; Moore, David ; Zimic, Mirko | BMC | 2019-01-25T15:02:14ZBACKGROUND: Tuberculosis (TB) is a major global health problem and drug resistance compromises the efforts to control this disease. Pyrazinamide (PZA) is an important drug used in both first and second line treatment regimes. However, its comple[...]![]()
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Ponce, Reynaldo ; León-Janampa, Nancy ; Gilman, Robert H. ; Liendo, Ruddy ; Roncal, Elisa ; Luis, Sueline ; Quiñones-García, Stefany ; Silverstein, Zach ; Garcia, Hector H. ; Gonzales, Armando ; Sheen, Patricia ; Zimic, Mirko ; Pajuelo, Monica J. ; Cysticercosis Working Group in Peru | Elsevier | 2018-11-30T02:09:28ZCysticercosis is a worldwide parasitic disease of humans and pigs principally caused by infection with the larvae of the pork tapeworm Taenia solium. Through the use of the recently-made-available T. solium genome, we identified a gene within a [...]![]()
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Rueda, Daniel ; Furukawa, Roberto ; Fuentes, Patricia ; Comina, Germán ; Rey De Castro, Nicolás G. ; Requena, David ; Gilman, Robert H. ; Sheen, Patricia ; Zimic, Mirko | Medknow Publications | 2018-11-30T02:09:28ZIntroduction: Tuberculosis (TB) is a significant cause of morbidity and mortality worldwide. The patient compliance with the long treatment regimens is essential for successful eradication. Pyrazinamide (PZA) shortens these regimens from 9 to 6 [...]![]()
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Jibaja, Sandro ; Oyola, Vanessa ; Berastain, Arturo ; Ramos, Daniel ; Roncal, Elisa ; Medina, Juan Carlos ; Untiveros, Graciela ; Sheen, Patricia ; Hurtado, Jasmín | Sociedad Química del Perú | 2019-08-08T15:23:48ZLos microorganismos acidófilos son predominantes en los ecosistemas de aguas ácidas de minas, encontrándose en abundancia la especie Acidithiobacillus ferrooxidans. El objetivo del estudio fue producir electricidad en Celdas de Combustible Micro[...]![]()
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Meinzen, Christopher ; Proaño, Alvaro ; Gilman, Robert H. ; Caviedes, Luz ; Coronel, Jorge ; Zimic, Mirko ; Sheen, Patricia | Elsevier | 2019-02-06T14:45:55ZBACKGROUND: Pyrazinamide (PZA) is the most important drug against the latent stage of tuberculosis (TB) and is used in both first and second line treatment regimens. The continued increase in multi-drug resistant TB and the prevalence of PZA res[...]![]()
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Phelan, Jody-E. ; Coll, Francesc ; Bergval, Indra ; Anthony, Richard-M. ; Warren, Rob ; Sampson, Samantha-L. ; Gey-van-Pittius, Nicolaas-C. ; Glynn, Judith-R. ; Crampin, Amelia-C. ; Alves, Adriana ; Bessa, Theolis-Barbosa ; Campino, Susana ; Dheda, Keertan ; Grandjean, Louis ; Hasan, Rumina ; Hasan, Zahra ; Miranda, Anabela ; Moore, David ; Panaiotov, Stefan ; Perdigão, João ; Portugal, Isabel ; Sheen, Patricia ; de-Oliveira-Sousa, Erivelton ; Streicher, Elizabeth-M. ; van-Helden, Paul-D. ; Viveiros, Miguel ; Hibberd, Martin-L. ; Pain, Arnab ; McNerney, Ruth ; Clark, Taane-G. | BMC | 2019-02-06T14:45:57ZBACKGROUND: Approximately 10% of the Mycobacterium tuberculosis genome is made up of two families of genes that are poorly characterized due to their high GC content and highly repetitive nature. The PE and PPE families are typified by their hig[...]![]()
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León-Janampa, Nancy ; Zimic, Mirko ; Shinkaruk, Svitlana ; Quispe-Marcatoma, J. ; Gutarra, Abel ; Le Bourdon, Gwénaëlle ; Gayot, Marion ; Changanaqui, Katherina ; Gilman, Robert H. ; Fouquet, Eric ; Sheen, Patricia ; Szlosek, Magali | IOP Publishing | 2020-07-14T00:02:31ZMycobacterium tuberculosis is the cause of one of the diseases with the highest mortality and morbidity rate in the Americas and in the world. In developing countries, the diagnosis of tuberculosis (TB) is based on baciloscopy and bacteriologica[...]![]()
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Grandjean, Louis ; Iwamoto, Tomotada ; Lithgow, Anna ; Gilman, Robert H. ; Arikawa, Kentaro ; Nakanishi, Noriko ; Martin, Laura ; Castillo, Edith ; Alarcon, Valentina ; Coronel, Jorge ; Solano, Walter ; Aminian, Minoo ; Guezala, Claudia ; Rastogi, Nalin ; Couvin, David ; Sheen, Patricia ; Zimic, Mirko ; Moore, David A. J. | Public Library of Science | 2019-02-06T14:53:10ZBACKGROUND: The comparison of Mycobacterium tuberculosis bacterial genotypes with phenotypic, demographic, geospatial and clinical data improves our understanding of how strain lineage influences the development of drug-resistance and the sprea[...]