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Dudley, Matthew Z. ; Sheen, Patricia ; Gilman, Robert H. ; Ticona, Eduardo ; Friedland, Jon S. ; Kirwan, Daniela E. ; Caviedes, Luz ; Rodriguez, Richard ; Cabrera, Lilia Z. ; Coronel, Jorge ; Grandjean, Louis ; Moore, David A. J. ; Evans, Carlton A. ; Huaroto, Luz ; Chavez-Perez, Victor ; Zimic, Mirko | American Society of Tropical Medicine and Hygiene | 2019-02-06T14:45:12ZHospital infection control measures are crucial to tuberculosis (TB) control strategies within settings caring for human immunodeficiency virus (HIV)-positive patients, as these patients are at heightened risk of developing TB. Pyrazinamide (PZA[...]texto impreso
Shah, Jyotsna ; Weltman, Helena ; Narciso, Patricia ; Murphy, Christina ; Poruri, Akhila ; Baliga, Shrikala ; Sharon, Leesha ; York, Mary ; Cunningham, Gail ; Miller, Steve ; Caviedes, Luz ; Gilman, Robert ; Desmond, Edward ; Ramasamy, Ranjan | Public Library of Science | 2019-01-25T15:18:33ZTwo rapid dual color fluorescence in situ hybridization (FISH) assays were evaluated for detecting M. tuberculosis and related pathogens in cultures. The MN Genus-MTBC FISH assay uses an orange fluorescent probe specific for the Mycobacterium tu[...]texto impreso
Proaño, Alvaro ; Bravard, Marjory A. ; López, José W. ; Lee, Gwenyth O. ; Bui, David ; Datta, Sumona ; Comina, Germán ; Zimic, Mirko ; Coronel, Jorge ; Caviedes, Luz ; Cabrera, Jose L. ; Salas, Antonio ; Ticona, Eduardo ; Vu, Nancy M. ; Kirwan, Daniela E. ; Loader, Maria-Cristina I. ; Friedland, Jon S. ; Moore, David A. J. ; Evans, Carlton A. ; Tracey, Brian H. ; Gilman, Robert H. | Oxford University Press | 2019-01-25T16:59:37ZBackground: Cough is the major determinant of tuberculosis transmission. Despite this, there is a paucity of information regarding characteristics of cough frequency throughout the day and in response to tuberculosis therapy. Here we evaluate th[...]texto impreso
López, José W. ; Loader, Maria-Cristina I. ; Smith, Daniel ; Pastorius, Daniel ; Bravard, Marjory ; Caviedes, Luz ; Romero, Karina M. ; Clark, Taryn ; Checkley, William ; Ticona, Eduardo ; Friedland, Jon S. ; Gilman, Robert H. | American Society of Tropical Medicine and Hygiene | 2018-11-30T03:10:46ZTo reduce transmission of tuberculosis (TB) in resource-limited countries where TB remains a major cause of mortality, novel diagnostic tools are urgently needed. We evaluated the fractional concentration of exhaled nitric oxide (FeNO) as an eas[...]texto impreso
Martin, Laura ; Coronel, Jorge ; Faulx, Dunia ; Valdez, Melissa ; Metzler, Mutsumi ; Crudder, Chris ; Castillo, Edith ; Caviedes, Luz ; Grandjean, Louis ; Rodriguez, Mitzi ; Friedland, Jon S. ; Gilman, Robert H. ; Moore, David A. J. | Public Library of Science | 2020-06-10T18:12:20ZBACKGROUND: Even though the WHO-endorsed, non-commercial MODS assay offers rapid, reliable TB liquid culture and phenotypic drug susceptibility testing (DST) at lower cost than any other diagnostic, uptake has been patchy. In part this reflects [...]texto impreso
Kirwan, Daniela E. ; Ugarte-Gil, Cesar ; Gilman, Robert H. ; Caviedes, Luz ; Rizvi, Hasan ; Ticona, Eduardo ; Chavez, Gonzalo ; Cabrera, Jose Luis ; Matos, Eduardo D. ; Evans, Carlton A. ; Moore, David A. J. ; Friedland, Jon S. ; Lymph Node TB Working Group | American Society for Microbiology | 2019-02-06T14:52:38ZIn this study, 132 patients with lymphadenopathy were investigated. Fifty-two (39.4%) were diagnosed with tuberculosis (TB). The microscopic observation drug susceptibility (MODS) assay provided rapid (13 days), accurate diagnosis (sensitivity, [...]texto impreso
Proaño, Alvaro ; Bravard, Marjory A. ; Tracey, Brian H. ; López, José W. ; Comina, Germán ; Zimic, Mirko ; Coronel, Jorge ; Lee, Gwenyth O'Neil ; Caviedes, Luz ; Cabrera, Jose Luis ; Salas, Antonio ; Ticona, Eduardo ; Kirwan, Daniela E. ; Friedland, Jon S. ; Evans, Carlton A. ; Moore, David A. ; Gilman, Robert H. | BMJ Publishing Group | 2019-02-06T14:51:43ZINTRODUCTION: Cough is a key symptom of tuberculosis (TB) as well as the main cause of transmission. However, a recent literature review found that cough frequency (number of coughs per hour) in patients with TB has only been studied once, in 19[...]texto impreso
Meinzen, Christopher ; Proaño, Alvaro ; Gilman, Robert H. ; Caviedes, Luz ; Coronel, Jorge ; Zimic, Mirko ; Sheen, Patricia | Elsevier | 2019-02-06T14:45:55ZBACKGROUND: Pyrazinamide (PZA) is the most important drug against the latent stage of tuberculosis (TB) and is used in both first and second line treatment regimens. The continued increase in multi-drug resistant TB and the prevalence of PZA res[...]texto impreso
Martin, Laura J. ; Roper, Martha H. ; Grandjean, Louis ; Gilman, Robert H. ; Coronel, Jorge ; Caviedes, Luz ; Friedland, Jon S. ; Moore, David A. J. | BMC | 2019-02-06T14:45:55ZBACKGROUND: Early identification of patients with drug-resistant tuberculosis (DR-TB) increases the likelihood of treatment success and interrupts transmission. Resource-constrained settings use risk profiling to ration the use of drug suscepti[...]
