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Lee, Gwenyth O. ; Comina, Germán ; Hernández-Córdova, Gustavo ; Naik, Nehal ; Gayoso, Oscar ; Ticona, Eduardo ; Coronel, Jorge ; Evans, Carlton A. ; Zimic, Mirko ; Paz-Soldan, Valerie A. ; Gilman, Robert H. ; Oberhelman, Richard | Public Library of Science | 2020-07-14T00:02:31ZCough is a characteristic symptom of tuberculosis, is the main cause of transmission, and is used to assess treatment response. We aimed to identify the best measure of cough severity and characterize changes during initial tuberculosis therapy.[...]texto impreso
Proaño, Alvaro ; Bui, David P. ; López, José W. ; Vu, Nancy M. ; Bravard, Marjory A. ; Lee, Gwenyth O. ; Tracey, Brian H. ; Xu, Ziyue ; Comina, Germán ; Ticona, Eduardo ; Mollura, Daniel J. ; Friedland, Jon S. ; Moore, David A. J. ; Evans, Carlton A. ; Caligiuri, Philip ; Gilman, Robert H. | Elsevier | 2018-11-30T03:10:43ZBACKGROUND: Cough frequency, and its duration, is a biomarker that can be used in low-resource settings without the need of laboratory culture and has been associated with transmission and treatment response. Radiologic characteristics associate[...]texto impreso
Dudley, Matthew Z. ; Sheen, Patricia ; Gilman, Robert H. ; Ticona, Eduardo ; Friedland, Jon S. ; Kirwan, Daniela E. ; Caviedes, Luz ; Rodriguez, Richard ; Cabrera, Lilia Z. ; Coronel, Jorge ; Grandjean, Louis ; Moore, David A. J. ; Evans, Carlton A. ; Huaroto, Luz ; Chavez-Perez, Victor ; Zimic, Mirko | American Society of Tropical Medicine and Hygiene | 2019-02-06T14:45:12ZHospital infection control measures are crucial to tuberculosis (TB) control strategies within settings caring for human immunodeficiency virus (HIV)-positive patients, as these patients are at heightened risk of developing TB. Pyrazinamide (PZA[...]texto impreso
Gutierrez-Loli, Renzo ; Ferradas, Cusi ; Diestra, Andrea ; Traianou, Aliki ; Bowman, Natalie ; Bok, Jeroen ; Reimer-McAtee, Melissa ; Ramal, Cesar ; Ticona, Eduardo ; Steinberg, Hannah ; Mayta, Holger ; Calderón, Maritza ; Calla-Choque, Jaeson S. ; Sterling, Charles ; Gilman, Robert H. ; Toxoplasmosis Working Group in Peru and Bolivia | American Society of Tropical Medicine and Hygiene | 2019-07-04T16:59:29ZQuantitative polymerase chain reaction (qPCR) for Toxoplasma gondii multicopy genes has emerged as a promising strategy for sensitive detection of parasite DNA. qPCR can be performed from blood samples, which are minimally invasive to collect. H[...]texto impreso
Proaño, Alvaro ; Bravard, Marjory A. ; López, José W. ; Lee, Gwenyth O. ; Bui, David ; Datta, Sumona ; Comina, Germán ; Zimic, Mirko ; Coronel, Jorge ; Caviedes, Luz ; Cabrera, Jose L. ; Salas, Antonio ; Ticona, Eduardo ; Vu, Nancy M. ; Kirwan, Daniela E. ; Loader, Maria-Cristina I. ; Friedland, Jon S. ; Moore, David A. J. ; Evans, Carlton A. ; Tracey, Brian H. ; Gilman, Robert H. | Oxford University Press | 2019-01-25T16:59:37ZBackground: Cough is the major determinant of tuberculosis transmission. Despite this, there is a paucity of information regarding characteristics of cough frequency throughout the day and in response to tuberculosis therapy. Here we evaluate th[...]texto impreso
Metcalf, Tatiana ; Soria, Jaime ; Montano, Silvia M. ; Ticona, Eduardo ; Evans, Carlton A. ; Huaroto, Luz ; Kasper, Matthew ; Ramos, Eric S. ; Mori, Nicanor ; Jittamala, Podjanee ; Chotivanich, Kesinee ; Chavez, Irwin F. ; Singhasivanon, Pratap ; Pukrittayakamee, Sasithon ; Zunt, Joseph R. | Public Library of Science | 2018-11-30T03:10:46ZBACKGROUND: Meningitis caused by Mycobacterium tuberculosis is a major cause of morbidity and mortality worldwide. We evaluated the performance of cerebrospinal fluid (CSF) testing with the GeneXpert MTB/RIF assay versus traditional approaches f[...]texto impreso
López, José W. ; Loader, Maria-Cristina I. ; Smith, Daniel ; Pastorius, Daniel ; Bravard, Marjory ; Caviedes, Luz ; Romero, Karina M. ; Clark, Taryn ; Checkley, William ; Ticona, Eduardo ; Friedland, Jon S. ; Gilman, Robert H. | American Society of Tropical Medicine and Hygiene | 2018-11-30T03:10:46ZTo reduce transmission of tuberculosis (TB) in resource-limited countries where TB remains a major cause of mortality, novel diagnostic tools are urgently needed. We evaluated the fractional concentration of exhaled nitric oxide (FeNO) as an eas[...]texto impreso
Kirwan, Daniela E. ; Ugarte-Gil, Cesar ; Gilman, Robert H. ; Hasan Rizvi, Syed M. ; Cerrillo, Gustavo ; Cok, Jaime ; Ticona, Eduardo ; Cabrera, Jose Luis ; Matos, Eduardo D. ; Evans, Carlton A. ; Moore, David A. J. ; Friedland, Jon S. ; Lymph Node Tuberculosis Working Group | American Society of Tropical Medicine and Hygiene | 2019-01-25T15:18:36ZThe differential diagnosis for lymphadenopathy is wide and clinical presentations overlap, making obtaining an accurate diagnosis challenging. We sought to characterize the clinical and radiological characteristics, histological findings, and di[...]texto impreso
Ticona, Eduardo ; Huaroto, Luz ; Kirwan, Daniela E. ; Chumpitaz, Milagros ; Munayco, Cesar V. ; Maguina, Monica ; Tovar, Marco A. ; Evans, Carlton A. ; Escombe, Roderick ; Gilman, Robert H. | American Society of Tropical Medicine and Hygiene | 2019-02-06T14:48:07ZMultidrug-resistant tuberculosis (MDRTB) rates in a human immunodeficiency virus (HIV) care facility increased by the year 2000-56% of TB cases, eight times the national MDRTB rate. We reported the effect of tuberculosis infection control measu[...]texto impreso
Kirwan, Daniela E. ; Ugarte-Gil, Cesar ; Gilman, Robert H. ; Caviedes, Luz ; Rizvi, Hasan ; Ticona, Eduardo ; Chavez, Gonzalo ; Cabrera, Jose Luis ; Matos, Eduardo D. ; Evans, Carlton A. ; Moore, David A. J. ; Friedland, Jon S. ; Lymph Node TB Working Group | American Society for Microbiology | 2019-02-06T14:52:38ZIn this study, 132 patients with lymphadenopathy were investigated. Fifty-two (39.4%) were diagnosed with tuberculosis (TB). The microscopic observation drug susceptibility (MODS) assay provided rapid (13 days), accurate diagnosis (sensitivity, [...]texto impreso
Proaño, Alvaro ; Bravard, Marjory A. ; Tracey, Brian H. ; López, José W. ; Comina, Germán ; Zimic, Mirko ; Coronel, Jorge ; Lee, Gwenyth O'Neil ; Caviedes, Luz ; Cabrera, Jose Luis ; Salas, Antonio ; Ticona, Eduardo ; Kirwan, Daniela E. ; Friedland, Jon S. ; Evans, Carlton A. ; Moore, David A. ; Gilman, Robert H. | BMJ Publishing Group | 2019-02-06T14:51:43ZINTRODUCTION: Cough is a key symptom of tuberculosis (TB) as well as the main cause of transmission. However, a recent literature review found that cough frequency (number of coughs per hour) in patients with TB has only been studied once, in 19[...]
