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Painschab, M.S. ; Malpartida, G.E. ; Dávila-Roman, V.G. ; Gilman, R.H. ; Kolb, T.M. ; León-Velarde, F. ; Miranda, J.J. ; Checkley, W. | Mary Ann Liebert | 2019-02-22T14:55:00ZLong-term residence at high altitude is associated with the development of chronic mountain sickness (CMS), which is characterized by excessive erythrocytosis (EE). EE occurs under chronic hypoxia, and a strongly selected mutation in hypoxia-ind[...]texto impreso
Siques, P. ; Brito, J. ; Schwedhelm, E. ; Pena, E. ; León-Velarde, F. ; De La Cruz, J.J. ; Böger, R.H. ; Hannemann, J. | Frontiers Media | 2019-12-06T20:57:43ZBackground: Prolonged exposure to altitude-associated chronic hypoxia (CH) may cause high-altitude pulmonary hypertension (HAPH). Chronic intermittent hypobaric hypoxia (CIH) occurs in individuals who commute between sea level and high altitude.[...]texto impreso
Caffrey, D. ; Jaime Miranda, J. ; Gilman, R.H. ; Dávila-Roman, V.G. ; Cabrera, L. ; Dowling, R. ; Stewart, T. ; Bernabé-Ortiz, A. ; Wise, R. ; León-Velarde, F. ; Checkley, W. | BMC | 2020-06-10T18:11:38ZBackground: We sought to determine if adult residents living at high altitude have developed sufficient adaptation to a hypoxic environment to match the functional capacity of a similar population at sea level. To test this hypothesis, we compar[...]texto impreso
Richalet, J. P. ; Gazal, S. ; Espinoza, J. R. ; Austerlitz, F. ; Macarlupu, J. L. ; León-Velarde, F. ; Marchant, D. ; Gouya, L. | Federation of American Society of Experimental Biology | 2019-01-25T16:20:59ZChronic mountain sickness (CMS) is a pathological condition resulting from the loss of adaptation to high altitude. The syndrome is characterized by an excessive number of red blood cells (Excessive Erythropoiesis) associated with a high concent[...]texto impreso
Vizcardo-Galindo, G. ; León-Velarde, F. ; Villafuerte, F.C. | Mary Ann Liebert Inc. | 2020-12-14T16:11:08ZBackground: The soluble form of the erythropoietin (Epo) receptor (sEpoR) is an endogenous antagonist of Epo. Decreasing plasma sEpoR increases free Epo, thereby increasing the availability of the hormone. In humans, short-term intermittent norm[...]texto impreso
Childebayeva, A. ; Jones, T.R. ; Goodrich, J.M. ; León-Velarde, F. ; Rivera-Chira, M. ; Kiyamu, M. ; Brutsaert, T.D. ; Dolinoy, D.C. ; Bigham, A.W. | Taylor & Francis | 2019-12-06T20:57:46ZRecent discoveries indicate a genetic basis for high-altitude adaptation among human groups who have resided at high altitude for millennia, including Andeans, Tibetans, and Ethiopians. Yet, genetics alone does not explain the extent of variatio[...]texto impreso
Flores, K. ; Siques, P. ; Brito, J. ; Ordenes, S. ; Arriaza, K. ; Pena, E. ; León-Velarde, F. ; López, R. ; López de Pablo, Á.L. ; Arribas, S. | Frontiers Media | 2020-07-14T00:01:10ZBackground: Both chronic hypoxia (CH) and long-term chronic intermittent hypoxia (CIH) exposure lead to right ventricular hypertrophy (RVH). Weight loss is an effective intervention to improve cardiac function and energy metabolism in cardiac hy[...]texto impreso
Pena, E. ; Siques, P. ; Brito, J. ; Arribas, S.M. ; Böger, R. ; Hannemann, J. ; León-Velarde, F. ; González, M.C. ; López, M.R. ; de Pablo, Á.L.L. | MDPI AG | 2020-12-14T16:10:03ZOne of the consequences of high altitude (hypobaric hypoxia) exposure is the development of right ventricular hypertrophy (RVH). One particular type of exposure is long-term chronic intermittent hypobaric hypoxia (CIH); the molecular alterations[...]texto impreso
Obesity, a worldwide epidemic, has become a major health burden because it is usually accompanied by an increased risk for insulin resistance, diabetes, hypertension, cardiovascular diseases, and even some kinds of cancer. It also results in ass[...]texto impreso
Siques, P. ; Brito, J. ; Naveas, N. ; Pulido, R. ; De La Cruz, J.J. ; Mamani, M. ; León-Velarde, F. | Mary Ann Liebert | 2020-06-10T18:11:30ZPlasma and liver lipid profiles in rats exposed to chronic hypobaric hypoxia: Changes in metabolic pathways. High Alt Med Biol 15:388-395, 2014. - Lipid metabolism under chronic hypoxia (CH) has not received equal attention as intermittent hypox[...]
