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Llanos-Cuentas, Alejandro ; Casapía, Martin ; Chuquiyauri, Raúl ; Hinojosa, Juan-Carlos ; Kerr, Nicola ; Rosario, Maria ; Toovey, Stephen ; Arch, Robert H. ; Phillips, Margaret A. ; Rozenberg, Felix D. ; Bath, Jade ; Ng, Caroline L. ; Cowell, Annie N. ; Winzeler, Elizabeth A. ; Fidock, David A. ; Baker, Mark ; Möhrle, Jörg J. ; Hooft van Huijsduijnen, Rob ; Gobeau, Nathalie ; Araeipour, Nada ; Andenmatten, Nicole ; Rückle, Thomas ; Duparc, Stephan | Elsevier | 2018-11-30T02:09:29ZBACKGROUND: DSM265 is a novel, long-duration inhibitor of plasmodium dihydroorotate dehydrogenase (DHODH) with excellent selectivity over human DHODH and activity against blood and liver stages of Plasmodium falciparum. This study aimed to asses[...]texto impreso
LaMonte, Gregory M. ; Orjuela-Sanchez, Pamela ; Calla, Jaeson ; Wang, Lawrence T. ; Li, Shangzhong ; Swann, Justine ; Cowell, Annie N. ; Zou, Bing Yu ; Abdel-Haleem Mohamed, Alyaa M. ; Villa Galarce, Zaira Hellen ; Moreno, Marta ; Tong Rios, Carlos ; Vinetz, Joseph M. ; Lewis, Nathan ; Winzeler, Elizabeth A. | Nature Research | 2019-07-04T16:59:30ZThe exoerythrocytic stage of Plasmodium infection is a critical window for prophylactic intervention. Using genome-wide dual RNA sequencing of flow-sorted infected and uninfected hepatoma cells we show that the human mucosal immunity gene, mucin[...]texto impreso
Cowell, Annie N. ; Loy, Dorothy E. ; Sundararaman, Sesh A. ; Valdivia, Hugo ; Fisch, Kathleen ; Lescano, Andres G. ; Baldeviano, G. Christian ; Durand, Salomon ; Gerbasi, Vince ; Sutherland, Colin J. ; Nolder, Debbie ; Vinetz, Joseph M. ; Hahn, Beatrice H. ; Winzeler, Elizabeth A. | American Society of Microbiology | 2019-01-25T16:03:20ZWhole-genome sequencing (WGS) of microbial pathogens from clinical samples is a highly sensitive tool used to gain a deeper understanding of the biology, epidemiology, and drug resistance mechanisms of many infections. However, WGS of organisms [...]
