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Kariyawasam, R. ; Mukkala, A. ; Lau, R. ; Valencia, B. ; Llanos-Cuentas, A. ; Boggild, A.K. | Elsevier | 2018-10-10T23:27:56ZBackground: Leishmania RNA Virus-1 (LRV-1) is a double stranded RNA virus identified in strains of the Viannia subgenus in Latin America. Virulence factors (VFs) are gene products that augment pathogenicity of an organism, and are mostly constit[...]texto impreso
Kariyawasam, R. ; Grewal, J. ; Lau, R. ; Purssell, A. ; Valencia, B. M. ; Llanos-Cuentas, A. ; Boggild, A. K. | Oxford University Press | 2019-01-25T16:36:28ZBackgound. Species of the Leishmania Viannia (L. V.) subgenus harbor the double-stranded Leishmania RNA virus 1 (LRV-1), previously identified in isolates from Brazil and Peru. Higher levels of LRV-1 in metastasizing strains of L. V. guyanensis [...]texto impreso
Valencia, B. ; Lau, R. ; Kariyawasam, R. ; Shao, E. ; Llanos-Cuentas, A. ; Boggild, A.K. | Elsevier | 2018-10-10T23:27:55ZBackground: Due to the highly toxic nature of standard drugs used in the treatment of cutaneous leishmaniasis (CL), and overlapping clinical features of CL with ulcers due to fungal and mycobacterial infections, confirmatory diagnostic testing m[...]texto impreso
Kariyawasam, R. ; Lau, R. ; Valencia, B. ; Llanos-Cuentas, A. ; Boggild, A.K. | Elsevier | 2018-10-10T23:27:56ZBackground: American tegumentary leishmaniasis (ATL) comprises a discrete set of clinical presentations of leishmaniasis endemic to Latin America and particularly Peru. Leishmania RNA virus-1 (LRV-1) is a double stranded RNA virus identified in [...]texto impreso
Kariyawasam, R. ; Gascon, B. ; Mah, J. ; Lau, R. ; Valencia, B. ; Llanos-Cuentas, A. ; Boggild, A.K. | Elsevier | 2018-10-10T23:27:56ZBackground : Cutaneous leishmaniasis (CL) may present with an inflammatory phenotype, characterized by pain, erythema, and purulent exudate, which is typically treated with antibiotics prior to anti-Leishmania treatment. Although the inflammator[...]texto impreso
Mukkala, A. ; Kariyawasam, R. ; Lau, R. ; Valencia, B. ; Llanos-Cuentas, A. ; Boggild, A.K. | Elsevier | 2018-10-10T23:27:56ZBackground: Virulence factors (VF) are endogenous molecules that often enhance the pathogenicity of an organism. The role of host age on the immunopathogenesis of leishmaniasis is poorly understood. Despite pediatric populations being frequent v[...]texto impreso
Kariyawasam, R. ; Mukkala, A.N. ; Lau, R. ; Valencia, B.M. ; Llanos-Cuentas, A. ; Boggild, A.K. | BMC | 2019-12-06T21:02:56ZBackground: Leishmania RNA virus-1 (LRV1) is a double-stranded RNA virus identified in 20-25% of Viannia - species endemic to Latin America, and is believed to accelerate cutaneous to mucosal leishmaniasis over time. Our objective was to quantif[...]
