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Bordelon, Hali ; Ricks, Keersten M. ; Pask, Megan E. ; Russ, Patricia K. ; Solinas, Francesca ; Baglia, Mark L. ; Short, Philip A. ; Nel, Andrew ; Blackburn, Jonathan ; Dheda, Keertan ; Zamudio, Carlos ; Cáceres, Tatiana ; Wright, David W. ; Haselton, Frederick R. ; Pettit, April C. | Elsevier | 2019-01-25T15:02:22ZUrine samples are increasingly used for diagnosing infections including Escherichia coli, Ebola virus, and Zika virus. However, extraction and concentration of nucleic acid biomarkers from urine is necessary for many molecular detection strategi[...]texto impreso
Coll, Francesc ; Phelan, Jody ; Hill-Cawthorne, Grant A. ; Nair, Mridul B. ; Mallard, Kim ; Ali, Shahjahan ; Abdallah, Abdallah M. ; Alghamdi, Saad ; Alsomali, Mona ; Ahmed, Abdallah O. ; Portelli, Stephanie ; Oppong, Yaa ; Alves, Adriana ; Bessa, Theolis Barbosa ; Campino, Susana ; Caws, Maxine ; Chatterjee, Anirvan ; Crampin, Amelia C. ; Dheda, Keertan ; Furnham, Nicholas ; Glynn, Judith R. ; Grandjean, Louis ; Minh Ha, Dang ; Hasan, Rumina ; Hasan, Zahra ; Hibberd, Martin L. ; Joloba, Moses ; Jones-López, Edward C. ; Matsumoto, Tomoshige ; Miranda, Anabela ; Moore, David J. ; Mocillo, Nora ; Panaiotov, Stefan ; Parkhill, Julian ; Penha, Carlos ; Perdigão, João ; Portugal, Isabel ; Rchiad, Zineb ; Robledo, Jaime ; Sheen, Patricia ; Shesha, Nashwa Talaat ; Sirgel, Frik A. ; Sola, Christophe ; Oliveira Sousa, Erivelton ; Streicher, Elizabeth M. ; Helden, Paul Van ; Viveiros, Miguel ; Warren, Robert M. ; McNerney, Ruth ; Pain, Arnab ; Clark, Taane G. | Nature Research | 2018-11-30T03:10:47ZTo characterize the genetic determinants of resistance to antituberculosis drugs, we performed a genome-wide association study (GWAS) of 6,465 Mycobacterium tuberculosis clinical isolates from more than 30 countries. A GWAS approach within a mix[...]texto impreso
Pham, Thu Hang ; Peter, Jonathan ; Mello, Fernanda C. Q. ; Parraga, Tommy ; Lan, Nguyen Thi Ngoc ; Nabeta, Pamela ; Valli, Eloise ; Cáceres, Tatiana ; Dheda, Keertan ; Dorman, Susan E. ; Hillemann, Doris ; Gray, Christen M. ; Perkins, Mark D. | Elsevier | 2018-11-30T22:50:35ZOBJECTIVE: To evaluate the diagnostic performance of TB-LAMP, a manual molecular tuberculosis (TB) detection method, and provide comparison to the Xpert MTB/RIF assay. METHODS: In a large multicentre study, two sputum samples were collected from[...]texto impreso
Phelan, Jody-E. ; Coll, Francesc ; Bergval, Indra ; Anthony, Richard-M. ; Warren, Rob ; Sampson, Samantha-L. ; Gey-van-Pittius, Nicolaas-C. ; Glynn, Judith-R. ; Crampin, Amelia-C. ; Alves, Adriana ; Bessa, Theolis-Barbosa ; Campino, Susana ; Dheda, Keertan ; Grandjean, Louis ; Hasan, Rumina ; Hasan, Zahra ; Miranda, Anabela ; Moore, David ; Panaiotov, Stefan ; Perdigão, João ; Portugal, Isabel ; Sheen, Patricia ; de-Oliveira-Sousa, Erivelton ; Streicher, Elizabeth-M. ; van-Helden, Paul-D. ; Viveiros, Miguel ; Hibberd, Martin-L. ; Pain, Arnab ; McNerney, Ruth ; Clark, Taane-G. | BMC | 2019-02-06T14:45:57ZBACKGROUND: Approximately 10% of the Mycobacterium tuberculosis genome is made up of two families of genes that are poorly characterized due to their high GC content and highly repetitive nature. The PE and PPE families are typified by their hig[...]
