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Adaui, Vanessa ; Lye, Lon-Fye ; Akopyants, Natalia S. ; Zimic, Mirko ; Llanos-Cuentas, Alejandro ; Garcia, Lineth ; Maes, Ilse ; De Doncker, Simonne ; Dobson, Deborah E. ; Arevalo, Jorge ; Dujardin, Jean-Claude ; Beverley, Stephen M. | Oxford University Press | 2019-02-06T14:57:40ZCutaneous and mucosal leishmaniasis, caused in South America by Leishmania braziliensis, is difficult to cure by chemotherapy (primarily pentavalent antimonials [Sb(V)]). Treatment failure does not correlate well with resistance in vitro, and th[...]texto impreso
Best, Ivan ; Privat-Maldonado, Angela ; Cruz, Maria ; Zimic, Mirko ; Bras-Gonçalves, Rachel ; Lemesre, Jean-Loup ; Arevalo, Jorge | Frontiers Media | 2018-10-10T23:27:56ZClinical manifestations of American Tegumentary Leishmaniasis (ATL) include cutaneous (CL) and mucous forms (ML); however, there are asymptomatic individuals who despite being infected do not present any clinical manifestations. This study chara[...]texto impreso
Chamakh-Ayari, Rym ; Bras-Gonçalves, Rachel ; Bahi-Jaber, Narges ; Petitdidier, Elodie ; Markikou-Ouni, Wafa ; Aoun, Karim ; Moreno, Javier ; Carrillo, Eugenia ; Salotra, Poonam ; Kaushal, Himanshu ; Negi, Narender Singh ; Arevalo, Jorge ; Falconi-Agapito, Francesca ; Privat, Angela ; Cruz, Maria ; Pagniez, Julie ; Papierok, Gerard-Marie ; Rhouma, Faten Bel Haj ; Torres, Pilar ; Lemesre, Jean-Loup ; Chenik, Mehdi ; Meddeb-Garnaoui, Amel | Public Library of Science | 2020-06-10T18:12:17ZPSA (Promastigote Surface Antigen) belongs to a family of membrane-bound and secreted proteins present in several Leishmania (L.) species. PSA is recognized by human Th1 cells and provides a high degree of protection in vaccinated mice. We evalu[...]texto impreso
Cabanillas, Billy Joel ; Le Lamer, Anne-Cecile ; Olagnier, David ; Castillo, Denis ; Arevalo, Jorge ; Valadeau, Celine ; Coste, Agnes ; Pipy, Bernard ; Bourdy, Genevieve ; Sauvain, Michel ; Fabre, Nicolas | Elsevier | 2020-06-10T18:12:13ZETHNOPHARMACOLOGICAL RELEVANCE: Leaves and rhizomes of Renealmia thyrsoidea (Ruiz & Pav.) Poepp. & Endl. traditionally used in the Yanesha pharmacopoeia to treat skin infections such as leishmaniasis ulcers, or to reduce fever were chemically i[...]texto impreso
Jara, Marlene ; Berg, Maya ; Caljon, Guy ; de Muylder, Geraldine ; Cuypers, Bart ; Castillo, Denis ; Maes, Ilse ; Orozco, María Del Carmen ; Vanaerschot, Manu ; Dujardin, Jean-Claude ; Arevalo, Jorge | Public Library of Science | 2019-01-25T15:28:05ZIt was recently hypothesized that Leishmania amastigotes could constitute a semi-quiescent stage characterized by low replication and reduced metabolic activity. This concept developed with Leishmania (Leishmania) mexicana and Leishmania (Leishm[...]texto impreso
Nuhs, Andrea ; Schafer, Carola ; Zander, Dorothea ; Trube, Leona ; Tejera Nevado, Paloma ; Schmidt, Sonja ; Arevalo, Jorge ; Adaui, Vanessa ; Maes, Louis ; Dujardin, Jean-Claude ; Clos, Joachim | Elsevier | 2020-06-10T18:11:33ZProtozoa of the Leishmania genus cause a variety of disease forms that rank at the top of the list of neglected tropical diseases. Anti-leishmanial drugs based on pentavalent antimony have been the mainstay of therapy for over 60 years and resi[...]texto impreso
Suarez, Milagros ; Valencia, B. M. ; Jara, Marlene ; Alba, Milena ; Boggild, Andrea K. ; Dujardin, Jean-Claude ; Llanos-Cuentas, Alejandro ; Arevalo, Jorge ; Adaui, Vanessa | Public Library of Science | 2019-02-06T14:53:09ZBACKGROUND: Cutaneous leishmaniasis (CL) is a skin disease caused by the protozoan parasite Leishmania. Few studies have assessed the influence of the sample collection site within the ulcer and the sampling method on the sensitivity of parasito[...]texto impreso
Jara, Marlene ; Valencia, B. M. ; Adaui, Vanessa ; Alba, Milena ; Lau, Rachel ; Arevalo, Jorge ; Llanos-Cuentas, Alejandro ; Boggild, Andrea K. | American Society of Tropical Medicine and Hygiene | 2019-02-06T14:57:38ZMucosal leishmaniasis (ML) is a disfiguring manifestation of Leishmania (Viannia) infection. We evaluated parasite load (PL) over time as a potential biomarker of treatment outcome in ML. PL was assessed with kinetoplast DNA quantitative real-t[...]texto impreso
Barletta, Francesca ; Vandelannoote, Koen ; Collantes, Jimena ; Evans, Carlton A. ; Arevalo, Jorge ; Rigouts, Leen | American Society of Tropical Medicine and Hygiene | 2020-06-10T18:11:35ZReal-time polymerase chain reaction (qPCR) was optimized for detecting Mycobacterium tuberculosis in sputum. Sputum was collected from patients (N = 112) with suspected pulmonary tuberculosis, tested by smear microscopy, decontaminated, and spli[...]
