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Adaui, Vanessa ; Lye, Lon-Fye ; Akopyants, Natalia S. ; Zimic, Mirko ; Llanos-Cuentas, Alejandro ; Garcia, Lineth ; Maes, Ilse ; De Doncker, Simonne ; Dobson, Deborah E. ; Arevalo, Jorge ; Dujardin, Jean-Claude ; Beverley, Stephen M. | Oxford University Press | 2019-02-06T14:57:40ZCutaneous and mucosal leishmaniasis, caused in South America by Leishmania braziliensis, is difficult to cure by chemotherapy (primarily pentavalent antimonials [Sb(V)]). Treatment failure does not correlate well with resistance in vitro, and th[...]texto impreso
Martínez, Dalila Y. ; Llanos-Cuentas, Alejandro ; Dujardin, Jean-Claude ; Polman, Katja ; Adaui, Vanessa ; Boelaert, Marleen ; Verdonck, Kristien | Oxford University Press | 2020-07-14T00:02:33ZBACKGROUND: Endemic regions of cutaneous leishmaniasis (CL) and intestinal helminthiasis overlap. CL treatment with systemic pentavalent antimonial drugs (Sb(5+)) fails in 10%-30% of patients. The study objective was to assess the etiological ro[...]texto impreso
Jara, Marlene ; Berg, Maya ; Caljon, Guy ; de Muylder, Geraldine ; Cuypers, Bart ; Castillo, Denis ; Maes, Ilse ; Orozco, María Del Carmen ; Vanaerschot, Manu ; Dujardin, Jean-Claude ; Arevalo, Jorge | Public Library of Science | 2019-01-25T15:28:05ZIt was recently hypothesized that Leishmania amastigotes could constitute a semi-quiescent stage characterized by low replication and reduced metabolic activity. This concept developed with Leishmania (Leishmania) mexicana and Leishmania (Leishm[...]texto impreso
Nuhs, Andrea ; Schafer, Carola ; Zander, Dorothea ; Trube, Leona ; Tejera Nevado, Paloma ; Schmidt, Sonja ; Arevalo, Jorge ; Adaui, Vanessa ; Maes, Louis ; Dujardin, Jean-Claude ; Clos, Joachim | Elsevier | 2020-06-10T18:11:33ZProtozoa of the Leishmania genus cause a variety of disease forms that rank at the top of the list of neglected tropical diseases. Anti-leishmanial drugs based on pentavalent antimony have been the mainstay of therapy for over 60 years and resi[...]texto impreso
Suarez, Milagros ; Valencia, B. M. ; Jara, Marlene ; Alba, Milena ; Boggild, Andrea K. ; Dujardin, Jean-Claude ; Llanos-Cuentas, Alejandro ; Arevalo, Jorge ; Adaui, Vanessa | Public Library of Science | 2019-02-06T14:53:09ZBACKGROUND: Cutaneous leishmaniasis (CL) is a skin disease caused by the protozoan parasite Leishmania. Few studies have assessed the influence of the sample collection site within the ulcer and the sampling method on the sensitivity of parasito[...]
