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Bouton, Tara C. ; Phillips, Patrick P. J. ; Mitnick, Carole D. ; Peloquin, Charles A. ; Eisenach, Kathleen ; Patientia, Ramonde F. ; Lecca, Leonid ; Gotuzzo, Eduardo ; Gandhi, Neel R. ; Butler, Donna ; Diacon, Andreas H. ; Martel, Bruno ; Santillan, Juan ; Hunt, Kathleen Robergeau ; Vargas, Dante ; von Groote-Bidlingmaier, Florian ; Seas, Carlos ; Dianis, Nancy ; Moreno-Martinez, Antonio ; Horsburgh, C. Robert | BMC | 2019-01-25T16:59:36ZBACKGROUND: Current guidelines for treatment of multidrug-resistant tuberculosis (MDR-TB) are largely based on expert opinion and observational data. Fluoroquinolones remain an essential part of MDR-TB treatment, but the optimal dose of fluoroqu[...]texto impreso
Peloquin, Charles A. ; Phillips, Patrick P. J. ; Mitnick, Carole D. ; Eisenach, Kathleen ; Patientia, Ramonde F. ; Lecca, Leonid ; Gotuzzo, Eduardo ; Gandhi, Neel R. ; Butler, Donna ; Diacon, Andreas H. ; Martel, Bruno ; Santillan, Juan ; Hunt, Kathleen Robergeau ; Vargas, Dante ; von Groote-Bidlingmaier, Florian ; Seas, Carlos ; Dianis, Nancy ; Moreno-Martinez, Antonio ; Kaur, Pawandeep ; Horsburgh, C. Robert | American Society of Microbiology | 2018-11-30T17:17:13ZPatients with multidrug-resistant tuberculosis in Peru and South Africa were randomized to a weight-banded nominal dose of 11, 14, 17, or 20 mg/kg/day levofloxacin (minimum, 750 mg) in combination with other second-line agents. A total of 101 pa[...]texto impreso
Stucki, David ; Brites, Daniela ; Jeljeli, Leila ; Coscolla, Mireia ; Liu, Qingyun ; Trauner, Andrej ; Fenner, Lukas ; Rutaihwa, Liliana ; Borrell, Sonia ; Luo, Tao ; Gao, Qian ; Kato-Maeda, Midori ; Ballif, Marie ; Egger, Matthias ; Macedo, Rita ; Mardassi, Helmi ; Moreno, Milagros ; Tudo-Vilanova, Griselda ; Fyfe, Janet ; Globan, Maria ; Thomas, Jackson ; Jamieson, Frances ; Guthrie, Jennifer-L. ; Asante-Poku, Adwoa ; Yeboah-Manu, Dorothy ; Wampande, Eddie ; Ssengooba, Willy ; Joloba, Moses ; Henry-Boom, W. ; Basu, Indira ; Bower, James ; Saraiva, Margarida ; Vaconcellos, Sidra-E. G. ; Suffys, Philip ; Koch, Anastasia ; Wilkinson, Robert ; Gail-Bekker, Linda ; Malla, Bijaya ; Ley, Serej-D. ; Beck, Hans-Peter ; de-Jong, Bouke-C. ; Toit, Kadri ; Sanchez-Padilla, Elisabeth ; Bonnet, Maryline ; Gil-Brusola, Ana ; Frank, Matthias ; Penlap-Beng, Veronique-N. ; Eisenach, Kathleen ; Alani, Issam ; Wangui-Ndung'u, Perpetual ; Revathi, Gunturu ; Gehre, Florian ; Akter, Suriya ; Ntoumi, Francine ; Stewart-Isherwood, Lynsey ; Ntinginya, Nyanda-E. ; Rachow, Andrea ; Hoelscher, Michael ; Cirillo, Daniela-Maria ; Skenders, Girts ; Hoffner, Sven ; Bakonyte, Daiva ; Stakenas, Petras ; Diel, Roland ; Crudu, Valeriu ; Moldovan, Olga ; Al-Hajoj, Sahal ; Otero, Larissa ; Barletta, Francesca ; Jane-Carter, E. ; Diero, Lameck ; Supply, Philip ; Comas, Inaki ; Niemann, Stefan ; Gagneux, Sebastien | Nature Research | 2019-02-06T14:48:07ZGeneralist and specialist species differ in the breadth of their ecological niches. Little is known about the niche width of obligate human pathogens. Here we analyzed a global collection of Mycobacterium tuberculosis lineage 4 clinical isolate[...]
