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Lopez, J.M. ; Antiparra, R. ; lippens, G. ; Zimic, M. ; Sheen, P. ; Maruenda, H. | Springer | 2019-12-06T21:04:50ZChagas disease is a trypanosomiasis disease inflicted by Trypanosoma cruzi parasite. In Latin America, at least 10 million people are infected and annually, 10,000 casualties are deplored. Macrophage infectivity potentiator protein is one of the[...]texto impreso
Florentini, E.A. ; Angulo, N. ; Gilman, R.H. ; Alcántara, R. ; Roncal, E. ; Antiparra, R. ; Toscano, E. ; Vallejos, K. ; Kirwan, D. ; Zimic, M. ; Sheen, P. | Public Library of Science | 2020-12-14T16:06:23ZPyrazinamide (PZA) susceptibility testing in Mycobacterium tuberculosis (Mtb) is a current area of development and PZA-resistant strains are increasingly prevalent. Previous studies have demonstrated that the detection of pyrazinoic acid (POA), [...]texto impreso
Sheen, P. ; Monsalve, A. ; Campos, J. ; Huerta, R. ; Antiparra, R. ; Arteaga, H. ; Duran, P. ; Bueno, C. ; Kirwan, D.E. ; Gilman, R.H. ; Zimic, M. | American Society for Microbiology | 2020-12-14T16:10:13ZMycobacterium tuberculosis nicotinamidase-pyrazinamidase (PZAse) is a metalloenzyme that catalyzes conversion of nicotinamide-pyrazinamide to nicotinic acid-pyrazinoic acid. This study investigated whether a metallochaperone is required for opti[...]texto impreso
Alcántara, R. ; Fuentes, P. ; Antiparra, R. ; Santos, M. ; Gilman, R.H. ; Kirwan, D.E. ; Zimic, M. ; Sheen, P. | American Society for Microbiology | 2019-12-06T21:02:57ZAlthough pyrazinamide (PZA) is a key component of first- and second-line tuberculosis treatment regimens, there is no gold standard to determine PZA resistance. Approximately 50% of multidrug-resistant tuberculosis (MDR-TB) and over 90% of exten[...]texto impreso
Vallejos-Sánchez, K. ; Lopez, J.M. ; Antiparra, R. ; Toscano, E. ; Saavedra, H. ; Kirwan, D.E. ; Amzel, L.M. ; Gilman, R.H. ; Maruenda, H. ; Sheen, P. ; Zimic, M. | Nature Research | 2020-12-14T16:10:22ZPyrazinamide (PZA) is an antibiotic used in first- and second-line tuberculosis treatment regimens. Approximately 50% of multidrug-resistant tuberculosis and over 90% of extensively drug-resistant tuberculosis strains are also PZA resistant. Des[...]texto impreso
Supo-Escalante, R.R. ; Médico, A. ; Gushiken, E. ; Olivos-Ramírez, G.E. ; Quispe, Y. ; Torres, F. ; Zamudio, M. ; Antiparra, R. ; Mario Amzel, L. ; Gilman, R.H. ; Sheen, P. ; Zimic, M. | Public Library of Science | 2020-12-14T16:10:16ZBackground: Pyrazinamide is an important drug against the latent stage of tuberculosis and is used in both first- and second-line treatment regimens. Pyrazinamide-susceptibility test usually takes a week to have a diagnosis to guide initial ther[...]
