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Bui, David P. ; Oren, Eyal ; Roe, Denise J. ; Brown, Heidi E. ; Harris, Robin B. ; Knight, Gwenan M. ; Gilman, Robert H. ; Grandjean, Louis | Oxford University Press | 2018-11-30T02:09:28ZBackground: The majority of tuberculosis transmission occurs in community settings. The primary aim of this study was to assess the association between exposure to community venues and multidrug-resistant tuberculosis (MDR-TB) disease. The secon[...]texto impreso
Grandjean, Louis ; Gilman, Robert H. ; Iwamoto, Tomatada ; Koser, Claudio U. ; Coronel, Jorge ; Zimic, Mirko ; Torok, M. Estee ; Ayabina, Diepreye ; Kendall, Michelle ; Fraser, Christophe ; Harris, Simon ; Parkhill, Julian ; Peacock, Sharon J. ; Moore, David A. J. ; Colijn, Caroline | Public Library of Science | 2019-01-25T15:02:21ZBACKGROUND: Multidrug-resistant tuberculosis poses a major threat to the success of tuberculosis control programs worldwide. Understanding how drug-resistant tuberculosis evolves can inform the development of new therapeutic and preventive strat[...]texto impreso
Dudley, Matthew Z. ; Sheen, Patricia ; Gilman, Robert H. ; Ticona, Eduardo ; Friedland, Jon S. ; Kirwan, Daniela E. ; Caviedes, Luz ; Rodriguez, Richard ; Cabrera, Lilia Z. ; Coronel, Jorge ; Grandjean, Louis ; Moore, David A. J. ; Evans, Carlton A. ; Huaroto, Luz ; Chavez-Perez, Victor ; Zimic, Mirko | American Society of Tropical Medicine and Hygiene | 2019-02-06T14:45:12ZHospital infection control measures are crucial to tuberculosis (TB) control strategies within settings caring for human immunodeficiency virus (HIV)-positive patients, as these patients are at heightened risk of developing TB. Pyrazinamide (PZA[...]texto impreso
Moradigaravand, Danesh ; Grandjean, Louis ; Martinez, Elena ; Li, Hao ; Zheng, Jun ; Coronel, Jorge ; Moore, David ; Torok, M. Estee ; Sintchenko, Vitali ; Huang, Hairong ; Javid, Babak ; Parkhill, Julian ; Peacock, Sharon-J. ; Koser, Claudio-U. | American Society of Microbiology | 2019-02-06T14:51:22Ztexto impreso
Martin, Laura ; Coronel, Jorge ; Faulx, Dunia ; Valdez, Melissa ; Metzler, Mutsumi ; Crudder, Chris ; Castillo, Edith ; Caviedes, Luz ; Grandjean, Louis ; Rodriguez, Mitzi ; Friedland, Jon S. ; Gilman, Robert H. ; Moore, David A. J. | Public Library of Science | 2020-06-10T18:12:20ZBACKGROUND: Even though the WHO-endorsed, non-commercial MODS assay offers rapid, reliable TB liquid culture and phenotypic drug susceptibility testing (DST) at lower cost than any other diagnostic, uptake has been patchy. In part this reflects [...]texto impreso
Coll, Francesc ; Phelan, Jody ; Hill-Cawthorne, Grant A. ; Nair, Mridul B. ; Mallard, Kim ; Ali, Shahjahan ; Abdallah, Abdallah M. ; Alghamdi, Saad ; Alsomali, Mona ; Ahmed, Abdallah O. ; Portelli, Stephanie ; Oppong, Yaa ; Alves, Adriana ; Bessa, Theolis Barbosa ; Campino, Susana ; Caws, Maxine ; Chatterjee, Anirvan ; Crampin, Amelia C. ; Dheda, Keertan ; Furnham, Nicholas ; Glynn, Judith R. ; Grandjean, Louis ; Minh Ha, Dang ; Hasan, Rumina ; Hasan, Zahra ; Hibberd, Martin L. ; Joloba, Moses ; Jones-López, Edward C. ; Matsumoto, Tomoshige ; Miranda, Anabela ; Moore, David J. ; Mocillo, Nora ; Panaiotov, Stefan ; Parkhill, Julian ; Penha, Carlos ; Perdigão, João ; Portugal, Isabel ; Rchiad, Zineb ; Robledo, Jaime ; Sheen, Patricia ; Shesha, Nashwa Talaat ; Sirgel, Frik A. ; Sola, Christophe ; Oliveira Sousa, Erivelton ; Streicher, Elizabeth M. ; Helden, Paul Van ; Viveiros, Miguel ; Warren, Robert M. ; McNerney, Ruth ; Pain, Arnab ; Clark, Taane G. | Nature Research | 2018-11-30T03:10:47ZTo characterize the genetic determinants of resistance to antituberculosis drugs, we performed a genome-wide association study (GWAS) of 6,465 Mycobacterium tuberculosis clinical isolates from more than 30 countries. A GWAS approach within a mix[...]texto impreso
Warren, Joshua L. ; Grandjean, Louis ; Moore, David A. J. ; Lithgow, Anna ; Coronel, Jorge ; Sheen, Patricia ; Zelner, Jonathan L. ; Andrews, Jason R. ; Cohen, Ted | BMC | 2018-11-30T17:17:14ZBACKGROUND: Congregate settings may serve as institutional amplifiers of tuberculosis (TB) and multidrug-resistant tuberculosis (MDR-TB). We analyze spatial, epidemiological, and pathogen genetic data prospectively collected from neighborhoods s[...]texto impreso
Huang, Chuan-Chin ; Becerra, Mercedes C. ; Calderon, Roger ; Contreras, Carmen ; Galea, Jerome ; Grandjean, Louis ; Lecca, Leonid ; Yataco, Rosa ; Zhang, Zibiao ; Murray, Megan | American Thoracic Society | 2020-07-14T00:01:17ZRATIONALE: The World Health Organization recommends the use of isoniazid alone or in combination with rifapentine to treat latent tuberculosis infection. The recent rise of drug-resistant tuberculosis has complicated the choice of latent tubercu[...]texto impreso
Sheen, Patricia ; Requena, David ; Gushiken, Eduardo ; Gilman, Robert H. ; Antiparra, Ricardo ; Lucero, Bryan ; Lizárraga, Pilar ; Cieza, Basilio ; Roncal, Elisa ; Grandjean, Louis ; Pain, Arnab ; McNerney, Ruth ; Clark, Taane G. ; Moore, David ; Zimic, Mirko | BMC | 2019-01-25T15:02:14ZBACKGROUND: Tuberculosis (TB) is a major global health problem and drug resistance compromises the efforts to control this disease. Pyrazinamide (PZA) is an important drug used in both first and second line treatment regimes. However, its comple[...]texto impreso
Martin, Laura J. ; Roper, Martha H. ; Grandjean, Louis ; Gilman, Robert H. ; Coronel, Jorge ; Caviedes, Luz ; Friedland, Jon S. ; Moore, David A. J. | BMC | 2019-02-06T14:45:55ZBACKGROUND: Early identification of patients with drug-resistant tuberculosis (DR-TB) increases the likelihood of treatment success and interrupts transmission. Resource-constrained settings use risk profiling to ration the use of drug suscepti[...]texto impreso
Phelan, Jody-E. ; Coll, Francesc ; Bergval, Indra ; Anthony, Richard-M. ; Warren, Rob ; Sampson, Samantha-L. ; Gey-van-Pittius, Nicolaas-C. ; Glynn, Judith-R. ; Crampin, Amelia-C. ; Alves, Adriana ; Bessa, Theolis-Barbosa ; Campino, Susana ; Dheda, Keertan ; Grandjean, Louis ; Hasan, Rumina ; Hasan, Zahra ; Miranda, Anabela ; Moore, David ; Panaiotov, Stefan ; Perdigão, João ; Portugal, Isabel ; Sheen, Patricia ; de-Oliveira-Sousa, Erivelton ; Streicher, Elizabeth-M. ; van-Helden, Paul-D. ; Viveiros, Miguel ; Hibberd, Martin-L. ; Pain, Arnab ; McNerney, Ruth ; Clark, Taane-G. | BMC | 2019-02-06T14:45:57ZBACKGROUND: Approximately 10% of the Mycobacterium tuberculosis genome is made up of two families of genes that are poorly characterized due to their high GC content and highly repetitive nature. The PE and PPE families are typified by their hig[...]texto impreso
Grandjean, Louis ; Iwamoto, Tomotada ; Lithgow, Anna ; Gilman, Robert H. ; Arikawa, Kentaro ; Nakanishi, Noriko ; Martin, Laura ; Castillo, Edith ; Alarcon, Valentina ; Coronel, Jorge ; Solano, Walter ; Aminian, Minoo ; Guezala, Claudia ; Rastogi, Nalin ; Couvin, David ; Sheen, Patricia ; Zimic, Mirko ; Moore, David A. J. | Public Library of Science | 2019-02-06T14:53:10ZBACKGROUND: The comparison of Mycobacterium tuberculosis bacterial genotypes with phenotypic, demographic, geospatial and clinical data improves our understanding of how strain lineage influences the development of drug-resistance and the sprea[...]texto impreso
Knight, Gwenan M. ; Zimic, Mirko ; Funk, Sebastian ; Gilman, Robert H. ; Friedland, Jon S. ; Grandjean, Louis | The Royal Society | 2018-11-30T23:41:30ZThe relative fitness of drug-resistant versus susceptible bacteria in an environment dictates resistance prevalence. Estimates for the relative fitness of resistant Mycobacterium tuberculosis (Mtb) strains are highly heterogeneous and mostly der[...]texto impreso
Grandjean, Louis ; Gilman, Robert H. ; Martin, Laura ; Soto, Esther ; Castro, Beatriz ; Lopez, Sonia ; Coronel, Jorge ; Castillo, Edith ; Alarcon, Valentina ; Lopez, Virginia ; San Miguel, Angela ; Quispe, Neyda ; Asencios, Luis ; Dye, Christopher ; Moore, David A. J. | Public Library of Science | 2019-02-06T14:53:08ZBACKGROUND: The "fitness" of an infectious pathogen is defined as the ability of the pathogen to survive, reproduce, be transmitted, and cause disease. The fitness of multidrug-resistant tuberculosis (MDRTB) relative to drug-susceptible tuberc[...]texto impreso
There are an estimated 10 million new cases of tuberculosis worldwide annually, with 282,000 new or relapsed cases each year reported from the Americas. With improvements in genome sequencing technology, it is now possible to study the genetic d[...]
