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High altitude natives are reported to have outstanding work capacity in spite of the challenge of oxygen transport and delivery in hypoxia. To evaluate the developmental effect of lifelong exposure to hypoxia on aerobic capacity, VO2peak was me[...]texto impreso
Brutsaert, Tom D. ; Kiyamu, Melisa ; Elias Revollendo, Gianpietro ; Isherwood, Jenna L. ; Lee, Frank S. ; Rivera-Ch, Maria ; Leon-Velarde, Fabiola ; Ghosh, Sudipta ; Bigham, Abigail W. | National Academy of Sciences | 2019-12-06T21:02:54ZHighland native Andeans have resided at altitude for millennia. They display high aerobic capacity (VO2max) at altitude, which may be a reflection of genetic adaptation to hypoxia. Previous genomewide (GW) scans for natural selection have nomin[...]texto impreso
Kiyamu, Melisa ; Leon-Velarde, Fabiola ; Rivera-Chira, Maria ; Elias, Gianpietro ; Brutsaert, Tom D. | Mary Ann Liebert | 2019-02-06T14:52:35ZKiyamu, Melisa, Fabiola Leon-Velarde, Maria Rivera-Chira, Gianpietro Elias, and Tom D. Brutsaert. Developmental effects determine submaximal arterial oxygen saturation in Peruvian Quechua. High Alt Med Biol 16, 138-146, 2015.--Andean high altitu[...]texto impreso
Ghosh, Sudipta ; Kiyamu, Melisa ; Contreras, Paloma ; Leon-Velarde, Fabiola ; Bigham, Abigail ; Brutsaert, Tom D. | Wiley | 2019-12-06T20:57:51ZOBJECTIVES: Andean and Tibetan high-altitude natives exhibit a high concentration of nitric oxide (NO) in the lungs, suggesting that NO plays an adaptive role in offsetting hypobaric hypoxia. We examined the exhaled NO concentration as well as p[...]texto impreso
Childebayeva, Ainash ; Jones, Tamara R. ; Goodrich, Jaclyn M. ; Leon-Velarde, Fabiola ; Rivera-Chira, Maria ; Kiyamu, Melisa ; Brutsaert, Tom D. ; Dolinoy, Dana C. ; Bigham, Abigail W. | Taylor & Francis | 2019-07-04T17:00:18ZRecent discoveries indicate a genetic basis for high-altitude adaptation among human groups who have resided at high altitude for millennia, including Andeans, Tibetans, and Ethiopians. Yet, genetics alone does not explain the extent of variati[...]
