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Coll, Francesc ; Phelan, Jody ; Hill-Cawthorne, Grant A. ; Nair, Mridul B. ; Mallard, Kim ; Ali, Shahjahan ; Abdallah, Abdallah M. ; Alghamdi, Saad ; Alsomali, Mona ; Ahmed, Abdallah O. ; Portelli, Stephanie ; Oppong, Yaa ; Alves, Adriana ; Bessa, Theolis Barbosa ; Campino, Susana ; Caws, Maxine ; Chatterjee, Anirvan ; Crampin, Amelia C. ; Dheda, Keertan ; Furnham, Nicholas ; Glynn, Judith R. ; Grandjean, Louis ; Minh Ha, Dang ; Hasan, Rumina ; Hasan, Zahra ; Hibberd, Martin L. ; Joloba, Moses ; Jones-López, Edward C. ; Matsumoto, Tomoshige ; Miranda, Anabela ; Moore, David J. ; Mocillo, Nora ; Panaiotov, Stefan ; Parkhill, Julian ; Penha, Carlos ; Perdigão, João ; Portugal, Isabel ; Rchiad, Zineb ; Robledo, Jaime ; Sheen, Patricia ; Shesha, Nashwa Talaat ; Sirgel, Frik A. ; Sola, Christophe ; Oliveira Sousa, Erivelton ; Streicher, Elizabeth M. ; Helden, Paul Van ; Viveiros, Miguel ; Warren, Robert M. ; McNerney, Ruth ; Pain, Arnab ; Clark, Taane G. | Nature Research | 2018-11-30T03:10:47ZTo characterize the genetic determinants of resistance to antituberculosis drugs, we performed a genome-wide association study (GWAS) of 6,465 Mycobacterium tuberculosis clinical isolates from more than 30 countries. A GWAS approach within a mix[...]texto impreso
Sheen, Patricia ; Requena, David ; Gushiken, Eduardo ; Gilman, Robert H. ; Antiparra, Ricardo ; Lucero, Bryan ; Lizárraga, Pilar ; Cieza, Basilio ; Roncal, Elisa ; Grandjean, Louis ; Pain, Arnab ; McNerney, Ruth ; Clark, Taane G. ; Moore, David ; Zimic, Mirko | BMC | 2019-01-25T15:02:14ZBACKGROUND: Tuberculosis (TB) is a major global health problem and drug resistance compromises the efforts to control this disease. Pyrazinamide (PZA) is an important drug used in both first and second line treatment regimes. However, its comple[...]
