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Rueda, Daniel ; Bernard, Christine ; Gandy, Lucas ; Capton, Estelle ; Boudjelloul, Rachid ; Brossier, Florence ; Veziris, Nicolas ; Zimic, Mirko ; Sougakoff, Wladimir | Medknow Publications | 2018-11-30T03:10:46ZBackground: The main mechanism of resistance to PZA in Mycobacterium tuberculosis relies on mutations on its pyrazinamidase/nicotinamidase. Recently, a rapid colorimetric test relying on the PCR-based in vitro-synthesized-PZase assay has been re[...]texto impreso
Solis, Leonardo ; Coronel, Jorge ; Rueda, Daniel ; Gilman, Robert H. ; Sheen, Patricia ; Zimic, Mirko | Elsevier | 2019-02-06T14:57:42ZTuberculosis (TB) control efforts are hampered by a mismatch in diagnostic technology. Lack of adequate early diagnostics and Multi-drug resistant (MDR) detection is a critical problem in control efforts. Alternate and novel diagnostic approache[...]texto impreso
Rueda, Daniel ; Furukawa, Roberto ; Fuentes, Patricia ; Comina, Germán ; Rey De Castro, Nicolás G. ; Requena, David ; Gilman, Robert H. ; Sheen, Patricia ; Zimic, Mirko | Medknow Publications | 2018-11-30T02:09:28ZIntroduction: Tuberculosis (TB) is a significant cause of morbidity and mortality worldwide. The patient compliance with the long treatment regimens is essential for successful eradication. Pyrazinamide (PZA) shortens these regimens from 9 to 6 [...]
