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Vargas, A. ; Ríos, A. ; Grandjean, L. ; Kirwan, D. ; Gilman, R. ; Sheen, P. ; Zimic, M. | Wolters Kluwer Medknow Publications | 2020-12-14T16:11:07ZBackground: Rifampicin (RIF) resistance in Mycobacterium tuberculosis is frequently caused by mutations in the rpoB gene. These mutations are associated with a fitness cost, which can be overcome by compensatory mutations in other genes, among w[...]texto impreso
Florentini, E.A. ; Angulo, N. ; Gilman, R.H. ; Alcántara, R. ; Roncal, E. ; Antiparra, R. ; Toscano, E. ; Vallejos, K. ; Kirwan, D. ; Zimic, M. ; Sheen, P. | Public Library of Science | 2020-12-14T16:06:23ZPyrazinamide (PZA) susceptibility testing in Mycobacterium tuberculosis (Mtb) is a current area of development and PZA-resistant strains are increasingly prevalent. Previous studies have demonstrated that the detection of pyrazinoic acid (POA), [...]
