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Vargas, A. ; Ríos, A. ; Grandjean, L. ; Kirwan, D. ; Gilman, R. ; Sheen, P. ; Zimic, M. | Wolters Kluwer Medknow Publications | 2020-12-14T16:11:07ZBackground: Rifampicin (RIF) resistance in Mycobacterium tuberculosis is frequently caused by mutations in the rpoB gene. These mutations are associated with a fitness cost, which can be overcome by compensatory mutations in other genes, among w[...]texto impreso
There are an estimated 10 million new cases of tuberculosis worldwide annually, with 282,000 new or relapsed cases each year reported from the Americas. With improvements in genome sequencing technology, it is now possible to study the genetic d[...]
