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Determination of potentially novel compensatory mutations in rpoc associated with rifampin resistance and rpob mutations in Mycobacterium tuberculosis Clinical isolates from peru

Vargas, A. ; Ríos, A. ; Grandjean, L. ; Kirwan, D. ; Gilman, R. ; Sheen, P. ; Zimic, M. | Wolters Kluwer Medknow Publications | 2020-12-14T16:11:07Z

Background: Rifampicin (RIF) resistance in Mycobacterium tuberculosis is frequently caused by mutations in the rpoB gene. These mutations are associated with a fitness cost, which can be overcome by compensatory mutations in other genes, among w[...]

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