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Nanomaterials have unique properties and characteristics derived from their shape and small size that are not present in bulk materials. If size and shape are decisive, the synthesis method used, which determines the above parameters, is equally[...]texto impreso
Martínez Carmona, Marina ; Qui P., Ho ; Morand, Jeremy ; García Fontecha, Ana ; Ortega, Enrique ; Luiza C.S., Erthal ; Ruiz-Hernandez, Eduardo ; Santana, Dolores M. ; Ruiz, José ; Vallet Regí, María ; Gun’ko, Yurii | American Chemical Society | 2020-07-06In the process of synthesis of a new drug, as important as the drug itself is the formulation used, because the same compound can present a very different efficacy depending on how it is administered. In this work, we demonstrate how the antitum[...]texto impreso
Martínez Carmona, Marina ; Izquierdo Barba, Isabel ; Colilla, Montserrat ; Vallet Regí, María | Elsevier | 2019-07-03The ability of bacteria to form biofilms hinders any conventional treatment for chronic infections and has serious socio-economic implications. For this purpose, a nanocarrier capable of overcoming the barrier of the mucopolysaccharide matrix of[...]texto impreso
Martínez Carmona, Marina ; Colilla, Montserrat ; Ruiz González, M. Luisa ; González Calbet, José M. ; Vallet Regí, María | Elsevier | 2016-05-01This work demonstrates that high resolution transmission electron microscopy (HRTEM) is an essential tool to understand drug delivery performance of mesoporous silica materials, mainly those submitted to functionalization processes involving har[...]texto impreso
Martínez Carmona, Marina ; Lozano Borregón, Daniel ; Colilla Nieto, Montserrat ; Vallet Regí, María | Elsevier | 2017-11-07A novel multifunctional nanodevice based in doxorubicin (DOX)-loaded mesoporous silica nanoparticles (MSNs) as nanoplatforms for the assembly of different building blocks has been developed for bone cancer treatment. These building blocks consis[...]texto impreso
Martínez Carmona, Marina ; Baeza, Alejandro ; Rodriguez Milla, Miguel A. ; García Castro, Javier ; Vallet Regí, María | Royal Society of Chemistry | 2015-06-05A novel phototriggered drug delivery nanocarrier, which exhibits very high tumor cytotoxicity against human tumoral cells, is presented. This device is based on mesoporous silica nanoparticles decorated with a biocompatible protein shell cleavab[...]texto impreso
La nanomedicina es una disciplina científica que ha experimentado un gran apogeo en los últimos años, lo que ha permitido mejorar la calidad y la expectativa de vida en la sociedad contemporánea. Gracias a ella se han desarrollado nuevos nanomat[...]texto impreso
Martínez Carmona, Marina ; Lozano Borregón, Daniel ; Baeza, Alejandro ; Colilla, Montserrat ; Vallet Regí, María | Royal Society of Chemistry | 2017-09-19A novel singlet-oxygen sensitive drug delivery nanocarrier able to release their cargo after exposure to visible (Vis) light of a common lamp is presented. This nanodevice is based on mesoporous silica nanoparticles (MSN) decorated with porphyri[...]texto impreso
Colilla, Montserrat ; Martínez Carmona, Marina ; Sánchez-Salcedo, Sandra ; Ruiz González, M. Luisa ; González Calbet, José M. ; Vallet Regí, María | Royal Society of Chemistry | 2014A novel zwitterionic SBA-15 type bioceramic with dual antibacterial capability has been synthesized. The cocondensation route has been employed to functionalize SBA-15 with primary and secondary amine groups. The resulting material exhibits text[...]texto impreso
Martínez Carmona, Marina ; Lozano Borregón, Daniel ; Colilla, Montserrat ; Vallet Regí, María | 2016Topotecan (TOP), a water-soluble derivative of camptothecin, is a potent antitumor agent that is receiving growing attention for the treatment of several types of cancer. However, one of the major constraints in the clinical use of this drug is [...]texto impreso
The use of nanomaterials for the treatment of solid tumours is receiving increasing attention by the scientific community. Among them, mesoporous silica nanoparticles (MSNs) exhibit unique features that make them suitable nanocarriers to host, t[...]texto impreso
In the last two decades, zinc oxide (ZnO) semiconductor Quantum dots (QDs) have been shown to have fantastic luminescent properties, which together with their low-cost, low-toxicity and biocompatibility have turned these nanomaterials into one o[...]
