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Introduction: Nanocarriers have emerged as a powerful alternative for cancer therapy.Indeed, they are promising candidates to tackle the acquired resistance of surviving cells against antiproliferative drugs – the so-called multidrug resistance [...]texto impreso
Baeza, Alejandro ; Colilla, Montserrat ; Varas Muriel, María José ; Vallet Regí, María | Informa Healthcare | 2015Mesoporous silica nanoparticles (MSNPs)are one of the most promising inorganic drug delivery systems(DDSs). The design and development of tumour-targeted MSNPs with stimuli-responsive drug release capability aim at enhancing the efficiency and m[...]texto impreso
Pedraza, Daniel ; Díez, Jaime ; Izquierdo-Barba, Isabel ; Colilla, Montserrat ; Vallet Regí, María | De Gruyter Open | 2018-01-24This manuscript reports an effective new alternative for the management of bone infection by the 5 development of an antibiotic nanocarrier able to penetrate bacterial biofilm, thus enhancing antimicrobial effectiveness. This nanosystem, also de[...]texto impreso
Martínez Carmona, Marina ; Izquierdo Barba, Isabel ; Colilla, Montserrat ; Vallet Regí, María | Elsevier | 2019-07-03The ability of bacteria to form biofilms hinders any conventional treatment for chronic infections and has serious socio-economic implications. For this purpose, a nanocarrier capable of overcoming the barrier of the mucopolysaccharide matrix of[...]texto impreso
Martínez Carmona, Marina ; Colilla, Montserrat ; Ruiz González, M. Luisa ; González Calbet, José M. ; Vallet Regí, María | Elsevier | 2016-05-01This work demonstrates that high resolution transmission electron microscopy (HRTEM) is an essential tool to understand drug delivery performance of mesoporous silica materials, mainly those submitted to functionalization processes involving har[...]texto impreso
González Ortiz, Blanca ; Colilla, Montserrat ; Díez, Jaime ; Pedraza, Daniel ; Guembe, Marta ; Izquierdo-Barba, Isabel ; Vallet Regí, María | Elsevie | 2018-03-01This work aims to provide an effective and novel solution for the treatment of infection by using nanovehicles loaded with antibiotics capable of penetrating the bacterial wall, thus increasing the antimicrobial effectiveness. These nanosystems,[...]texto impreso
Vallet Regí, María ; Colilla, Montserrat ; Izquierdo-Barba, Isabel ; Manzano García, Miguel | MDPI | 2017-12-25This manuscript reviews the recent progress on mesoporous silica nanoparticles as drug delivery systems. Their intrinsic structural, textural and chemical features permit to design versatile multifunctional nanosystems with the capability to tar[...]texto impreso
Encinas, Noemí ; Angulo, Mercedes ; Astorga, Carlos ; Colilla, Montserrat ; Izquierdo Barba, Isabel ; Vallet Regí, María | Elsevier Science | 2018-12-05The design of drug delivery systems needs to consider biocompatibility and host body recognition for an adequate actuation. In this work, mesoporous silica nanoparticles (MSNs) surfaces were successfully modified with two silane molecules to pro[...]texto impreso
Martínez Carmona, Marina ; Lozano Borregón, Daniel ; Baeza, Alejandro ; Colilla, Montserrat ; Vallet Regí, María | Royal Society of Chemistry | 2017-09-19A novel singlet-oxygen sensitive drug delivery nanocarrier able to release their cargo after exposure to visible (Vis) light of a common lamp is presented. This nanodevice is based on mesoporous silica nanoparticles (MSN) decorated with porphyri[...]texto impreso
Colilla, Montserrat ; Martínez Carmona, Marina ; Sánchez-Salcedo, Sandra ; Ruiz González, M. Luisa ; González Calbet, José M. ; Vallet Regí, María | Royal Society of Chemistry | 2014A novel zwitterionic SBA-15 type bioceramic with dual antibacterial capability has been synthesized. The cocondensation route has been employed to functionalize SBA-15 with primary and secondary amine groups. The resulting material exhibits text[...]texto impreso
Sánchez Salcedo, Sandra ; Colilla, Montserrat ; Izquierdo-Barba, Isabel ; Vallet Regí, María | Whioce Publishing Pte Ltd | 2016Bone implant infection constitutes a major sanitary concern which is associated to high morbidity and health costs. This manuscript focused on overviewing the main research efforts committed up to date to develop innovative alternatives to conve[...]texto impreso
Baeza García, Alejandro ; Manzano García, Miguel ; Colilla, Montserrat ; Vallet Regí, María | Royal Society of Chemistry | 2016-02-23Since 2001, when our research group proposed for the first time MCM-41 as a drug release system, the scientific community has demonstrated a growing interest in mesoporous silica nanoparticles (MSNs) for their revolutionary potential in nanomedi[...]texto impreso
Martínez Carmona, Marina ; Lozano Borregón, Daniel ; Colilla, Montserrat ; Vallet Regí, María | 2016Topotecan (TOP), a water-soluble derivative of camptothecin, is a potent antitumor agent that is receiving growing attention for the treatment of several types of cancer. However, one of the major constraints in the clinical use of this drug is [...]texto impreso
The use of nanomaterials for the treatment of solid tumours is receiving increasing attention by the scientific community. Among them, mesoporous silica nanoparticles (MSNs) exhibit unique features that make them suitable nanocarriers to host, t[...]texto impreso
Paris, J.L. ; Colilla, Montserrat ; Izquierdo-Barba, Isabel ; Manzano García, Miguel ; Vallet Regí, María | Springer Verlag | 2017Matrix degradation has a major impact on the release kinetics of drug delivery systems. Regarding ordered mesoporous silica materials for biomedical applications, their dissolution is an important parameter that should be taken into considerati[...]
