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Autor Vallet Regí, María |
Documentos disponibles escritos por este autor (177)
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Gisbert Garzarán, Miguel ; Berkmann, Julia ; Giasafaki, Dimitra ; Lozano Borregón, Daniel ; Spyrou, Konstantinos ; Manzano García, Miguel ; Steriotis, Theodore A ; Duda, Georg ; Schmidt-Bleek, Katharina ; Charalambopoulou, Georgia ; Vallet Regí, María | ACS PUBLICATIONS | 2020-03-05In this work, two types of mesoporous carbon particles with different morphology, size and pore structure have been functionalized with a self-immolative polymer sensitive to changes in pH and tested as drug nanocarriers. It is shown that their [...]![]()
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One of the major limitations of nanomedicine is the scarce penetration of nanoparticles in tumoral tissues. These constrains have been tried to be solved by different strategies, such as the employ of polyethyleneglycol (PEG) to avoid the opsoni[...]![]()
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Paris, J.L. ; Lafuente-Gómez, Nuria ; Cabañas Criado, Victoria ; Román, Jesús ; Peña, Juan ; Vallet Regí, María | Elsevier Science BV | 2019-03-013D porous scaffolds based on agarose and nanocrystalline apatite, two structural components that act as a temporary mineralized extracellular matrix, were prepared by the GELPOR3D method. This shaping technology allows the introduction of therma[...]![]()
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Martínez-Vázquez, F.J. ; Cabañas Criado, Maria Victoria ; Paris, J.L. ; Lozano, D. ; Vallet Regí, María | Elsevier | 2015Porous 3-D scaffolds consisting of gelatine and Si-doped hydroxyapatite were fabricated at room temperature by rapid prototyping. Microscopic characterization revealed a highly homogeneous structure, showing the pre-designed porosity (macroporos[...]![]()
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Cabañas Criado, Victoria ; Lozano Borregón, Daniel ; Torres-Pardo, A. ; Sobrino, C. ; González-Calvet, J. ; Arcos Navarrete, Daniel ; Vallet Regí, María | Elsevier | 2018-12-01Aminopropyl modified mesoporous SiO2 nanoparticles, MCM-41 type, have been synthesized by the co-condensation method from tetraethylorthosilicate (TEOS) and aminopropyltriethoxysilane (APTES). By means of modifying TEOS/APTES ratio we have carri[...]![]()
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Paris, J.L. ; Villaverde, Gonzalo ; Cabañas Criado, Maria Victoria ; Manzano García, Miguel ; Vallet Regí, María | Royal Society of Chemistry | 2018-04-11In this work we present the synthesis, characterization and in vitro biological evaluation of PEGylated and actively-targeted ultrasound-responsive hybrid mesoporous silica nanoparticles. This work covers the development of the chemical strategi[...]![]()
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The rise and development of nanotechnology has permitted to create of a wide number of systems able to accomplish new and advantageous features to treat cancer. However in many cases, the lone application of those new nanotherapeutics has proven[...]![]()
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3D scaffolds based in mesoporous bioactive glasses (MBGs) are being widely investigated to use in bone tissue engineering (TE) applications. These scaffolds are often obtained by rapid prototyping (RP) and exhibit an array of interconnected pore[...]![]()
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Guisasola, Eduardo ; Baeza, Alejandro ; Asin, Laura ; De la Fuente, J. M. ; Vallet Regí, María | Wiley-Blackwell | 2018-05-07Nanocarriers for cancer therapy have been extensively studied, but there is still some research that must be addressed in order to achieve their safe application. In this field, hyperthermia thermal treatments mediated by the us of responsive na[...]![]()
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Maycas, Marta ; Portolés Pérez, María Teresa ; Matesanz Sancho, María Concepción ; Buendía, Irene ; Linares, Javier ; Feito Castellano, María José ; Arcos Navarrete, Daniel ; Vallet Regí, María ; Plotkin, Lilian I. ; Esbrit, Pedro ; Gortázar, Arancha R. | Wiley | 2017-12Diabetes mellitus (DM) induces bone deterioration, while mechanical stimulation promotes osteocyte-driven bone formation. We aimed to evaluate the interaction of acute exposure (24 h) to high glucose (HG) with both the pro-survival effect confer[...]![]()
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Martínez Carmona, Marina ; Colilla, Montserrat ; Ruiz González, M. Luisa ; González Calbet, José M. ; Vallet Regí, María | Elsevier | 2016-05-01This work demonstrates that high resolution transmission electron microscopy (HRTEM) is an essential tool to understand drug delivery performance of mesoporous silica materials, mainly those submitted to functionalization processes involving har[...]![]()
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Sánchez Salcedo, Sandra ; Malavasi, Gianluca ; Salinas Sánchez, Antonio J. ; Lusvardi, Gigliola ; Rigamonti, Luca ; Menabue, Ledi ; Vallet Regí, María | MDPI | 2018-03-02Beneficial effects in bone cell growth and antibacterial action are currently attributed to Ga3+ ions. Thus, they can be used to upgrade mesoporous bioactive glasses (MBGs), investigated for tissue engineering, whenever they released therapeutic[...]![]()
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Villegas Díaz, María Rocío ; Baeza, Alejandro ; Vallet Regí, María | American Chemical Society | 2015-11-04Poor penetration of drug delivery nanocarriers within dense extracellular matrices constitutes one of the main liabilities of current nanomedicines. The conjugation of proteolytic enzymes on the nanoparticle surface constitutes an attractive alt[...]![]()
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Hybrid Enzyme-Polymeric Capsules/Mesoporous Silica Nanodevice for In Situ Cytotoxic Agent Generation
Baeza, Alejandro ; Guisasola, Eduardo ; Torres Pardo, Almudena ; González Calbet, José M. ; Melen, Gustavo J. ; Ramírez, Manuel ; Vallet Regí, María | Wiley | 2014-08-06A novel nanocarrier based on functionalized mesoporous silica nanoparticles able to transport a non-toxic pro-drug and the enzyme responsible for its activation is presented. This nanodevice is able to generate in situ cytotoxic species once acc[...]![]()
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Boffito, Monica ; Torchio, Alessandro ; Tonda-Turro, Chiara ; Laurano, Rosella ; Gisbert Garzarán, Miguel ; Berckmann, Julia C ; Cassino, Claudio ; Manzano García, Miguel ; Duda, Georg ; Vallet Regí, María ; Schmidt-Bleek, Katharina ; Ciardelli, Gianluca | Frontiers Media | 2020-02-15Injectable therapeutical formulations locally releasing their cargo with tunable kinetics in response to external biochemical/physical cues are gaining interest in the scientific community, with the aim to overcome the cons of traditional admini[...]