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Bone infection is a feared complication following surgery or trauma that remains as an extremely difficult disease to deal with. So far, the outcome of therapy could be improved with the design of 3D implants, which combine the merits of osseous[...]texto impreso
Vila, Mercedes ; García, Ana ; Girotti, Alessandra ; Alonso, Matilde ; Rodriguez Cabello, José Carlos ; González Vázquez, Arlyng ; Planell, Josep A. ; Engel, Elisabeth ; Buján, Julia ; García-Honduvilla, Natalio ; Vallet Regí, María | Elsevier | 2016The current study reports on the manufacturing by rapid prototyping technique of three-dimensional (3D) scaffolds based on silicon substituted hydroxyapatite with Elastin-like Recombinamers (ELRs) functionalized surfaces. Silicon doped hydroxyap[...]texto impreso
Nanomaterials have unique properties and characteristics derived from their shape and small size that are not present in bulk materials. If size and shape are decisive, the synthesis method used, which determines the above parameters, is equally[...]texto impreso
Introduction: Nanocarriers have emerged as a powerful alternative for cancer therapy.Indeed, they are promising candidates to tackle the acquired resistance of surviving cells against antiproliferative drugs – the so-called multidrug resistance [...]texto impreso
Baeza, Alejandro ; Colilla, Montserrat ; Varas Muriel, María José ; Vallet Regí, María | Informa Healthcare | 2015Mesoporous silica nanoparticles (MSNPs)are one of the most promising inorganic drug delivery systems(DDSs). The design and development of tumour-targeted MSNPs with stimuli-responsive drug release capability aim at enhancing the efficiency and m[...]texto impreso
Castillo, Rafael R. ; Lozano Borregón, Daniel ; González, Blanca ; Manzano García, Miguel ; Izquierdo-Barba, Isabel ; Vallet Regí, María | Taylor & Francis | 2019-03-22Introduction: Mesoporous silica nanoparticles (MSNs) are outstanding nanoplatforms for drug delivery. Herein, the most recent advances to turn MSN-based carriers into minimal side effect drug delivery agents are covered. Areas covered: This revi[...]texto impreso
Pedraza, Daniel ; Díez, Jaime ; Izquierdo-Barba, Isabel ; Colilla, Montserrat ; Vallet Regí, María | De Gruyter Open | 2018-01-24This manuscript reports an effective new alternative for the management of bone infection by the 5 development of an antibiotic nanocarrier able to penetrate bacterial biofilm, thus enhancing antimicrobial effectiveness. This nanosystem, also de[...]texto impreso
Martínez Carmona, Marina ; Qui P., Ho ; Morand, Jeremy ; García Fontecha, Ana ; Ortega, Enrique ; Luiza C.S., Erthal ; Ruiz-Hernandez, Eduardo ; Santana, Dolores M. ; Ruiz, José ; Vallet Regí, María ; Gun’ko, Yurii | American Chemical Society | 2020-07-06In the process of synthesis of a new drug, as important as the drug itself is the formulation used, because the same compound can present a very different efficacy depending on how it is administered. In this work, we demonstrate how the antitum[...]texto impreso
Montes-Casado, María ; Sanvicente, Adrián ; Casarrubios Molina, Laura ; Feito Castellano, María José ; Rojo, J.M. ; Vallet Regí, María ; Arcos Navarrete, Daniel ; Portoles, Pilar ; Portolés Pérez, María Teresa | MDPI | 2020-11-05Mesoporous bioactive glass nanospheres (NanoMBGs) have high potential for clinicalapplications. However, the impact of nanoparticles on the immune system needs to be addressed. In this study, the biocompatibility of SiO2-CaO NanoMBGs was evalua[...]texto impreso
Álvarez, Rafael ; Muñoz-Piña, Sandra ; González, Maria U. ; Izquierdo-Barba, Isabel ; Fernández-Martín, Iván ; Rico, Victor J. ; Arcos Navarrete, Daniel ; García-Valenzuela, Aurelio ; Palmero, Alberto ; Vallet Regí, María ; González-Elipe, Agustín R. ; García-Martín, José R. | MDPI | 2019-08-28Based on an already tested laboratory procedure, a new magnetron sputtering methodology to simultaneously coat two-sides of large area implants (up to ~15 cm2) with Ti nanocolumns in industrial reactors has been developed. By analyzing the requi[...]texto impreso
Estévez Sánchez, Héctor ; Palacios, Ainhoa ; Gil, David ; Anguita, Juan ; Vallet Regí, María ; González Ortiz, Blanca ; Prados Rosales, Rafael ; Luque-García, José L. | Frontiers Media SA | 2020-04-28Tuberculosis remains the leading cause of death from a single infection agent worldwide. In recent years, the occurrence of tuberculosis cases caused by drug-resistant strains has spread, and is expected to continue to grow. Therefore, the devel[...]texto impreso
Román Zaragoza, Jesús ; Cabañas Criado, Victoria ; Doadrio Villarejo, Juan Carlos ; Doadrio Villarejo, Antonio Luis ; García Diz, Luis ; García Fontecha, Ana ; Gutiérrez Ríos, María Teresa ; Lozano Fernández, Rafael ; Manzano García, Miguel ; Martínez Alonso, África ; Peña López, Juan ; Sánchez Salcedo, Sandra ; Vallet Regí, María | UCM | 2016-03-30Se ha creado un Entorno Virtual de Enseñanza y Aprendizaje (EVEA) circunscrito a la realización de prácticas en el Laboratorio de Química Inorgánica orientado a incrementar el grado de interacción entre el alumno con algún tipo de dificultad aud[...]texto impreso
Delpiano, Giulia ; Casula, Maria ; Piludu, Marco ; Corpino, Riccardo ; Ricci, Pier Carlo ; Vallet Regí, María ; Sanjust, Enrico ; Monduzzi, Maura ; Salis, Andrea | American Chemical Society | 2019-06-25The purpose of this work was the assembly of multicomponent nano-bioconjugates based on mesoporous silica nanoparticles (MSNs), proteins (bovine serum albumin, BSA, or lysozyme, LYZ), and gold nanoparticles (GNPs). These nanobioconjugates may fi[...]texto impreso
Díez Martínez, Roberto ; García Fernández, Esther ; Manzano García, Miguel ; Martínez, Angel ; Domenech, Mirian ; Vallet Regí, María ; García, Pedro | Nature Publishing Group | 2016-01-18Drug-loaded nanoparticles (NPs) can improve infection treatment by ensuring drug concentration at the right place within the therapeutic window. Poly(lactic-co-glycolic acid) (PLGA) NPs are able to enhance drug localization in target site and to[...]texto impreso
Moreno Zafra, Víctor Manuel ; Alvarez Corchado, Elena ; Izquierdo-Barba, Isabel ; Baeza, Alejandro ; Serrano López, Juana ; Vallet Regí, María | Wiley Online Library | 2020-04-21One of the major concerns in the application of nanocarriers in oncology is their scarce penetration capacity in tumoral tissues, which drastically compromises the effectivity. Living organisms as cells and bacteria present the capacity to navig[...]
