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Gisbert Garzarán, Miguel ; Lozano Borregón, Daniel ; Matsumoto, Kotaro ; Komcatsu, Aoi ; Manzano García, Miguel ; Tamanoi, Fuyuhiko ; Vallet Regí, María | ACS PUBLICATIONS | 2021-02-17The several biological barriers that nanoparticles might encounter when administered to a patient constitute the major bottleneck of nanoparticle7 mediated tumor drug delivery, preventing their successful translation into the clinic and reducing[...]texto impreso
Gisbert Garzarán, Miguel ; Berkmann, Julia ; Giasafaki, Dimitra ; Lozano Borregón, Daniel ; Spyrou, Konstantinos ; Manzano García, Miguel ; Steriotis, Theodore A ; Duda, Georg ; Schmidt-Bleek, Katharina ; Charalambopoulou, Georgia ; Vallet Regí, María | ACS PUBLICATIONS | 2020-03-05In this work, two types of mesoporous carbon particles with different morphology, size and pore structure have been functionalized with a self-immolative polymer sensitive to changes in pH and tested as drug nanocarriers. It is shown that their [...]texto impreso
Boffito, Monica ; Torchio, Alessandro ; Tonda-Turro, Chiara ; Laurano, Rosella ; Gisbert Garzarán, Miguel ; Berckmann, Julia C ; Cassino, Claudio ; Manzano García, Miguel ; Duda, Georg ; Vallet Regí, María ; Schmidt-Bleek, Katharina ; Ciardelli, Gianluca | Frontiers Media | 2020-02-15Injectable therapeutical formulations locally releasing their cargo with tunable kinetics in response to external biochemical/physical cues are gaining interest in the scientific community, with the aim to overcome the cons of traditional admini[...]texto impreso
Mesoporous silica nanoparticles have been broadly applied as drug delivery systems 14 owing to their exquisite features, such as excellent textural properties or biocompatibility. However, 15 there are various biological barriers that prevent th[...]texto impreso
Current chemotherapy treatments lack of great selectivity towards tumoral cells, which 13 leads to nonspecific drug distribution and subsequent side effects. In this regard, the use of 14 nanoparticles able to encapsulate and release therapeutic[...]texto impreso
Bone diseases, such as bone cancer, bone infection and osteoporosis, constitute a major issue for modern societies as a consequence of their progressive ageing. Even though these pathologies can be currently treated in the clinic, some of those [...]texto impreso
Gisbert Garzarán, Miguel ; Manzano García, Miguel ; Vallet Regí, María | MDPI (Multidisciplinary Digital Publishing Institute) | 2017-01-18The application of nanotechnology to medicine constitutes a major field of research nowadays. In particular, the use of mesoporous silica and carbon nanoparticles has attracted the attention of numerous researchers due to their unique properties[...]texto impreso
Gisbert Garzarán, Miguel ; Manzano García, Miguel ; Vallet Regí, María | 2017-12-23Self-immolative chemistry is based on the cascade of disassembling reactions triggered by the adequate stimulation and leading to the sequential release of the smaller constituent elements. This review will focus on the possibilities that this t[...]texto impreso
Gisbert Garzarán, Miguel ; Lozano Borregón, Daniel ; Vallet Regí, María ; Manzano García, Miguel | Royal Society of Chemistry | 2016-12-07A novel pH-sensitive nanocarrier based on mesoporous silica nanoparticles with self-immolative polymers blocking the pore openings is presented. Triggered release by acid pH is demonstrated, together with their in vitro biocompatibility and effe[...]
