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Castillo, Rafael R. ; Lozano Borregón, Daniel ; González, Blanca ; Manzano García, Miguel ; Izquierdo-Barba, Isabel ; Vallet Regí, María | Taylor & Francis | 2019-03-22Introduction: Mesoporous silica nanoparticles (MSNs) are outstanding nanoplatforms for drug delivery. Herein, the most recent advances to turn MSN-based carriers into minimal side effect drug delivery agents are covered. Areas covered: This revi[...]texto impreso
Román Zaragoza, Jesús ; Cabañas Criado, Victoria ; Doadrio Villarejo, Juan Carlos ; Doadrio Villarejo, Antonio Luis ; García Diz, Luis ; García Fontecha, Ana ; Gutiérrez Ríos, María Teresa ; Lozano Fernández, Rafael ; Manzano García, Miguel ; Martínez Alonso, África ; Peña López, Juan ; Sánchez Salcedo, Sandra ; Vallet Regí, María | UCM | 2016-03-30Se ha creado un Entorno Virtual de Enseñanza y Aprendizaje (EVEA) circunscrito a la realización de prácticas en el Laboratorio de Química Inorgánica orientado a incrementar el grado de interacción entre el alumno con algún tipo de dificultad aud[...]texto impreso
Díez Martínez, Roberto ; García Fernández, Esther ; Manzano García, Miguel ; Martínez, Angel ; Domenech, Mirian ; Vallet Regí, María ; García, Pedro | Nature Publishing Group | 2016-01-18Drug-loaded nanoparticles (NPs) can improve infection treatment by ensuring drug concentration at the right place within the therapeutic window. Poly(lactic-co-glycolic acid) (PLGA) NPs are able to enhance drug localization in target site and to[...]texto impreso
Gisbert Garzarán, Miguel ; Lozano Borregón, Daniel ; Matsumoto, Kotaro ; Komcatsu, Aoi ; Manzano García, Miguel ; Tamanoi, Fuyuhiko ; Vallet Regí, María | ACS PUBLICATIONS | 2021-02-17The several biological barriers that nanoparticles might encounter when administered to a patient constitute the major bottleneck of nanoparticle7 mediated tumor drug delivery, preventing their successful translation into the clinic and reducing[...]texto impreso
Vallet Regí, María ; Salinas Sánchez, Antonio J. ; Baeza, Alejandro ; Manzano García, Miguel | Elsevier | 2018-05-15texto impreso
Gisbert Garzarán, Miguel ; Berkmann, Julia ; Giasafaki, Dimitra ; Lozano Borregón, Daniel ; Spyrou, Konstantinos ; Manzano García, Miguel ; Steriotis, Theodore A ; Duda, Georg ; Schmidt-Bleek, Katharina ; Charalambopoulou, Georgia ; Vallet Regí, María | ACS PUBLICATIONS | 2020-03-05In this work, two types of mesoporous carbon particles with different morphology, size and pore structure have been functionalized with a self-immolative polymer sensitive to changes in pH and tested as drug nanocarriers. It is shown that their [...]texto impreso
Paris, J.L. ; Villaverde, Gonzalo ; Cabañas Criado, Maria Victoria ; Manzano García, Miguel ; Vallet Regí, María | Royal Society of Chemistry | 2018-04-11In this work we present the synthesis, characterization and in vitro biological evaluation of PEGylated and actively-targeted ultrasound-responsive hybrid mesoporous silica nanoparticles. This work covers the development of the chemical strategi[...]texto impreso
Boffito, Monica ; Torchio, Alessandro ; Tonda-Turro, Chiara ; Laurano, Rosella ; Gisbert Garzarán, Miguel ; Berckmann, Julia C ; Cassino, Claudio ; Manzano García, Miguel ; Duda, Georg ; Vallet Regí, María ; Schmidt-Bleek, Katharina ; Ciardelli, Gianluca | Frontiers Media | 2020-02-15Injectable therapeutical formulations locally releasing their cargo with tunable kinetics in response to external biochemical/physical cues are gaining interest in the scientific community, with the aim to overcome the cons of traditional admini[...]texto impreso
Peña López, Juan ; Cabañas Criado, Maria Victoria ; Doadrio Villarejo, Antonio Luis ; Doadrio Villarejo, Juan Carlos ; García Fontecha, Ana ; García Diz, Luis ; Gutiérrez Ríos, María Teresa ; Lozano Fernández, Rafael ; Manzano García, Miguel ; Martínez Alonso, África ; Román Zaragoza, Jesús ; Sánchez-Salcedo, Sandra ; Vallet Regí, María | 2015texto impreso
Vallet Regí, María ; Manzano García, Miguel ; Rodríguez Manas, L. ; Checa López, Marta ; Aapro, Matti ; Balducci, Lodovico | AlphaMed Press | 2017-02-20The management of cancer in older aged people is becoming a common problem due to the aging of the population. There are many variables determining the complex situation that are interconnected. Some of them can be assessed, such as risk of mort[...]texto impreso
Mohammad, Khalid S. ; Guise, Theresa A. ; Manzano García, Miguel ; Vallet Regí, María | Ommega publishers | 2017-01-27Cancer-associated muscle dysfunction represents a deadly clinical problem, with ca. 80% mortality together with an increased toxicity from cancer treatment.. The normal bone remodeling might be disrupted by tumor cells that metastasize to bone i[...]texto impreso
Paris, J.L. ; Manzano García, Miguel ; Cabañas Criado, Maria Victoria ; Vallet Regí, María | Royal Society of Chemistry | 2018-02-27A novel smart hierarchical ultrasound-responsive mesoporous silica nanocarrier for cancer therapy is here presented. This dynamic nanosystem has been designed to display different surface characteristics during its journey towards tumor cells. I[...]texto impreso
Vallet Regí, María ; Colilla, Montserrat ; Izquierdo-Barba, Isabel ; Manzano García, Miguel | MDPI | 2017-12-25This manuscript reviews the recent progress on mesoporous silica nanoparticles as drug delivery systems. Their intrinsic structural, textural and chemical features permit to design versatile multifunctional nanosystems with the capability to tar[...]texto impreso
Bone diseases, such as bone cancer, bone infection and osteoporosis, constitute a major issue for modern societies as a consequence of their progressive ageing. Even though these pathologies can be currently treated in the clinic, some of those [...]texto impreso
In the last few years Mesoporous Silica Nanoparticles (MSNs) have gained the attention of the nanomedicine research community, especially for the potential treatment of cancer. Although this topic has been reviewed before, periodic updates on su[...]
