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Autor Manzano García, Miguel |
Documentos disponibles escritos por este autor (32)
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Gisbert Garzarán, Miguel ; Lozano Borregón, Daniel ; Vallet Regí, María ; Manzano García, Miguel | Royal Society of Chemistry | 2016-12-07A novel pH-sensitive nanocarrier based on mesoporous silica nanoparticles with self-immolative polymers blocking the pore openings is presented. Triggered release by acid pH is demonstrated, together with their in vitro biocompatibility and effe[...]![]()
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Paris, J.L. ; Torre, Paz de la ; Cabañas Criado, Victoria ; Manzano García, Miguel ; Flores, Ana I. ; Vallet Regí, María | Elsevier Science BV | 2018-11-07A Trojan-horse strategy for cancer therapy employing tumor-tropic mesenchymal stem cells transfected with a non-viral nanovector is here presented. In this sense, ultrasound-responsive mesoporous silica nanoparticles were coated with a polycatio[...]![]()
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Paris, J.L. ; Román, M. ; Cabañas Criado, Maria Victoria ; Vallet Regí, María ; Manzano García, Miguel | Elsevier | 2015-05-30This work presents the tuning of drug-loaded scaffolds for bone regeneration as dual-drug delivery systems. Two therapeutic substances, zoledronic acid (anti-osteoporotic drug) and ibuprofen (antiinflammatory drug) were successfully incorporated[...]![]()
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Paris, J.L. ; Colilla, Montserrat ; Izquierdo-Barba, Isabel ; Manzano García, Miguel ; Vallet Regí, María | Springer Verlag | 2017Matrix degradation has a major impact on the release kinetics of drug delivery systems. Regarding ordered mesoporous silica materials for biomedical applications, their dissolution is an important parameter that should be taken into considerati[...]![]()
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Paris, J.L. ; Mannaris, Christophoros ; Cabañas Criado, Victoria ; Carlisle, Robert ; Manzano García, Miguel ; Vallet Regí, María ; Coussios, Constantin C. | Elsevier | 2017-12-12Mesoporous silica nanoparticles have been reported as suitable drug carriers, but their successful delivery to target tissues following systemic administration remains a challenge. In the present work, ultrasound-induced inertial cavitation was [...]![]()
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Nanotechnology, which has already revolutionised many technological areas, is expected to transform life sciences. In this sense, nanomedicine could address some of the most important limitations of conventional medicine. In general, nanomedicin[...]![]()
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Paris, J.L. ; Torre, Paz de la ; Cabañas Criado, Victoria ; Manzano García, Miguel ; Grau, Montserrat ; Flores, Ana I. ; Vallet Regí, María | Royal Society of Chemistry | 2017-05-07A new platform constituted by engineered responsive nanoparticles transported by human mesenchymal stem cells is here presented as a proof of concept. Ultrasound-responsive mesoporous silica nanoparticles are coated with polyethylenimine to favo[...]