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Guisasola, Eduardo ; Asin, Laura ; Beola, Lillianne ; De la Fuente, J. M. ; Baeza, Alejandro ; Vallet Regí, María | American Chemical Society | 2018-03-21In this study we present an innovation in the tumor treatment in vivo mediated by magnetic mesoporous silica nanoparticles (MMSNs). This device was built with iron oxide magnetic nanoparticles embedded in a mesoporous silica matrix and coated wi[...]texto impreso
Guisasola, Eduardo ; Baeza, Alejandro ; Talelli, Marina ; Arcos Navarrete, Daniel ; Vallet Regí, María | Royal Society of Chemistry | 2016-04-25Stimuli-responsive devices are novel tools widely studied in the nanomedicine research field. In this work, magnetic-responsive mesoporous silica nanoparticles (MMSNs) were coated with an engineered thermoresponsive co-polymer. Magnetic cores ar[...]texto impreso
Guisasola, Eduardo ; Baeza, Alejandro ; Asin, Laura ; De la Fuente, J. M. ; Vallet Regí, María | Wiley-Blackwell | 2018-05-07Nanocarriers for cancer therapy have been extensively studied, but there is still some research that must be addressed in order to achieve their safe application. In this field, hyperthermia thermal treatments mediated by the us of responsive na[...]texto impreso
Hybrid Enzyme-Polymeric Capsules/Mesoporous Silica Nanodevice for In Situ Cytotoxic Agent Generation
Baeza, Alejandro ; Guisasola, Eduardo ; Torres Pardo, Almudena ; González Calbet, José M. ; Melen, Gustavo J. ; Ramírez, Manuel ; Vallet Regí, María | Wiley | 2014-08-06A novel nanocarrier based on functionalized mesoporous silica nanoparticles able to transport a non-toxic pro-drug and the enzyme responsible for its activation is presented. This nanodevice is able to generate in situ cytotoxic species once acc[...]texto impreso
Guisasola, Eduardo ; Báez Rubio, Alejandro ; Talelli, Marina ; Arcos Navarrete, Daniel ; Moros, Maria ; Fuente, Jesus M. de la ; Vallet Regí, María | American Chemical Society | 2015-11-04Magnetically triggered drug delivery nanodevices have attracted great attention in nanomedicine, as they can feature as smart carriers releasing their payload at clinician's will. The key principle of these devices is based on the properties of [...]texto impreso
Villaverde, Gonzalo ; Gómez-Graña, Sergio ; Guisasola, Eduardo ; García, Isabel ; Hanske, Cristoph ; Liz-Marzan, Luis M ; Baeza, Alejandro ; Vallet Regí, María | Wiley-VCH Verlag GmbH | 2018Melanoma is one of the most severe public health issues worldwide, not onlybecause of the high number of cases but also for its poor prognosis in late stages. Therefore, early diagnosis and efficient treatment are key toward a future solution. H[...]
