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Autor Baeza, Alejandro |
Documentos disponibles escritos por este autor (28)
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Baeza, Alejandro ; Colilla, Montserrat ; Varas Muriel, María José ; Vallet Regí, María | Informa Healthcare | 2015Mesoporous silica nanoparticles (MSNPs)are one of the most promising inorganic drug delivery systems(DDSs). The design and development of tumour-targeted MSNPs with stimuli-responsive drug release capability aim at enhancing the efficiency and m[...]![]()
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Moreno Zafra, Víctor Manuel ; Alvarez Corchado, Elena ; Izquierdo-Barba, Isabel ; Baeza, Alejandro ; Serrano López, Juana ; Vallet Regí, María | Wiley Online Library | 2020-04-21One of the major concerns in the application of nanocarriers in oncology is their scarce penetration capacity in tumoral tissues, which drastically compromises the effectivity. Living organisms as cells and bacteria present the capacity to navig[...]![]()
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Guisasola, Eduardo ; Asin, Laura ; Beola, Lillianne ; De la Fuente, J. M. ; Baeza, Alejandro ; Vallet Regí, María | American Chemical Society | 2018-03-21In this study we present an innovation in the tumor treatment in vivo mediated by magnetic mesoporous silica nanoparticles (MMSNs). This device was built with iron oxide magnetic nanoparticles embedded in a mesoporous silica matrix and coated wi[...]![]()
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Villegas, Maria Rocio ; Baeza, Alejandro ; Usategui Corral, Alicia ; Ortiz-Romero, Pablo L. ; Pablos, J. L. ; Vallet Regí, María | Elsevier | 2018-05-03Fibrosis is a common lesion in different pathologic diseases and de?ned by the excessive accumulation ofcollagen. Different approaches have been used to treat different conditions characterized by ?brosis. TheFDA and EMA approved the use of coll[...]![]()
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Villegas Díaz, María Rocío ; Baeza, Alejandro ; Usategui Corral, Alicia ; Ortiz-Romero, Pablo L. ; Pablos, José L. ; Vallet Regí, María | Elsevier | 2018-05-04Fibrosis is a common lesion in different pathologic diseases and defined by the excessive accumulation of collagen. Different approaches have been used to treat different conditions characterized by fibrosis. The FDA and EMA approved the use of [...]![]()
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Guisasola, Eduardo ; Baeza, Alejandro ; Talelli, Marina ; Arcos Navarrete, Daniel ; Vallet Regí, María | Royal Society of Chemistry | 2016-04-25Stimuli-responsive devices are novel tools widely studied in the nanomedicine research field. In this work, magnetic-responsive mesoporous silica nanoparticles (MMSNs) were coated with an engineered thermoresponsive co-polymer. Magnetic cores ar[...]![]()
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Villaverde Cantizano, Gonzalo ; Nairi, Valentina ; Baeza, Alejandro ; Vallet Regí, María | Wiley | 2017-03-28The selective transportation of therapeutic agents to tumoral cells is usually achieved by their conjugation with targeting moieties able to recognize these cells. Unfortunately, simple and static targeting systems usually show selectivity lacks[...]![]()
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Vallet Regí, María ; Salinas Sánchez, Antonio J. ; Baeza, Alejandro ; Manzano García, Miguel | Elsevier | 2018-05-15![]()
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One of the major limitations of nanomedicine is the scarce penetration of nanoparticles in tumoral tissues. These constrains have been tried to be solved by different strategies, such as the employ of polyethyleneglycol (PEG) to avoid the opsoni[...]![]()
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Guisasola, Eduardo ; Baeza, Alejandro ; Asin, Laura ; De la Fuente, J. M. ; Vallet Regí, María | Wiley-Blackwell | 2018-05-07Nanocarriers for cancer therapy have been extensively studied, but there is still some research that must be addressed in order to achieve their safe application. In this field, hyperthermia thermal treatments mediated by the us of responsive na[...]![]()
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Villegas Díaz, María Rocío ; Baeza, Alejandro ; Vallet Regí, María | American Chemical Society | 2015-11-04Poor penetration of drug delivery nanocarriers within dense extracellular matrices constitutes one of the main liabilities of current nanomedicines. The conjugation of proteolytic enzymes on the nanoparticle surface constitutes an attractive alt[...]![]()
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Hybrid Enzyme-Polymeric Capsules/Mesoporous Silica Nanodevice for In Situ Cytotoxic Agent Generation
Baeza, Alejandro ; Guisasola, Eduardo ; Torres Pardo, Almudena ; González Calbet, José M. ; Melen, Gustavo J. ; Ramírez, Manuel ; Vallet Regí, María | Wiley | 2014-08-06A novel nanocarrier based on functionalized mesoporous silica nanoparticles able to transport a non-toxic pro-drug and the enzyme responsible for its activation is presented. This nanodevice is able to generate in situ cytotoxic species once acc[...]![]()
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Simmchen, Juliane ; Baeza, Alejandro ; Ruiz-Molina, Daniel ; Vallet Regí, María | Royal Society of Chemistry | 2014-06-03Biocatalytic propulsion is expected to play an important role in the future of micromotors as it might drastically increase the number of available fuelling reactions. However, most of the enzyme-propelled micromotors so far reported still rely [...]![]()
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Lopez, Victoria ; Villegas, Maria Rocio ; Rodriguez, Veronica ; Villaverde, Gonzalo ; Lozano, Daniel ; Baeza, Alejandro ; Vallet Regí, María | ACS | 2017-07-31The development of targeted nanocarriers able to be selectively internalized within tumor cells, and therefore to deliver anti-tumor drugs specifically to diseased cells, constitutes one of the most important goals in nano-oncology. Herein, the [...]![]()
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Nanoparticles have become a powerful tool in oncology not only as carrier of the highly toxic chemotherapeutic drugs but also as imaging contrast agents that provide valuable information about the state of the disease and its progression. The en[...]![]()
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Martínez, Angel ; Fuentes Paniagua, Elena ; Baeza, Alejandro ; Sánchez Nieves, Javier ; Cicuendez, Monica ; Gómez, Rafael ; Mata, F. Javier de la ; González, Blanca ; Vallet Regí, María | Wiley | 2015-09-15A novel nanosystem based on mesoporous silica nanoparticles covered with carbosilane dendrons grafted on the external surface of the nanoparticles is reported. This system is able to transport single-stranded oligonucleotide into cells, avoiding[...]![]()
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Martínez Carmona, Marina ; Baeza, Alejandro ; Rodriguez Milla, Miguel A. ; García Castro, Javier ; Vallet Regí, María | Royal Society of Chemistry | 2015-06-05A novel phototriggered drug delivery nanocarrier, which exhibits very high tumor cytotoxicity against human tumoral cells, is presented. This device is based on mesoporous silica nanoparticles decorated with a biocompatible protein shell cleavab[...]![]()
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Villaverde, Gonzalo ; Alfranca, Arantzazú ; González-Murillo, África ; Melen, Gustavo J. ; Castillo, Rafael R. ; Ramírez, Manuel ; Baeza, Alejandro ; Vallet Regí, María | Wiley-VCH | 2018-12-10The selective delivery of therapeutic and imaging agents to tumoral cells has been postulated as some of the most important challenges in nanomedicine field. The cellular selectivity of nanocarriers is usually achieved by their surface decoratio[...]![]()
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The development of nanomachines able to operate at the nanoscale, performing complex tasks such as drug delivery, precision surgery, or cell detection, constitutes one of the most important challenges in nanotechnology. The principles that rule [...]![]()
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The use of therapeutic proteins plays a fundamental role in the treatment of numerous diseases. The low physico-chemical stability of proteins in physiological conditions put their function at risk in the human body until they reach their target[...]![]()
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Villaverde, Gonzalo ; Baeza, Alejandro ; Melen, Gustavo J. ; Alfranca, Arantzazú ; Ramírez, Manuel ; Vallet Regí, María | Royal Society of Chemistry | 2015-04-14Novel targeting agents against neuroblastoma based on the meta-iodobenzylguanidine (MIBG) moiety were synthesized and biologically evaluated for nanocarrier vectorization. These compounds have been anchored on the surface of drug loaded mesoporo[...]![]()
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Martínez Carmona, Marina ; Lozano Borregón, Daniel ; Baeza, Alejandro ; Colilla, Montserrat ; Vallet Regí, María | Royal Society of Chemistry | 2017-09-19A novel singlet-oxygen sensitive drug delivery nanocarrier able to release their cargo after exposure to visible (Vis) light of a common lamp is presented. This nanodevice is based on mesoporous silica nanoparticles (MSN) decorated with porphyri[...]![]()
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Introduction: Stimuli-responsive nanomaterials for cancer therapy have attracted much interest recently due to their potential for improving the current standard of care. Different types of inorganic nanoparticles are widely employed for the dev[...]![]()
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The poor penetration of drug nanocarriers within tumor tissues is one of the most critical factors which limit their effectiveness. Nanomedicine has developed different strategies in order to overcome this important hurdle. Some of these strateg[...]![]()
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Introduction: Nanotechnology has provided new tools for addressing unmet clinical situations, especially in the oncology field. The development of smart nanocarriers able to deliver chemotherapeutic agents specifically to the diseased cells and [...]![]()
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Castillo Romero, Rafael ; Baeza, Alejandro ; Vallet Regí, María | Royal Society of Chemistry | 2017-01-20The discovery and control of the biological roles mediated by nucleic acids have turned them into a powerful tool for the development of advanced biotechnological materials. Much is the importance of those gene-keeping biomacromolecules that eve[...]![]()
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Villaverde, Gonzalo ; Gómez-Graña, Sergio ; Guisasola, Eduardo ; García, Isabel ; Hanske, Cristoph ; Liz-Marzan, Luis M ; Baeza, Alejandro ; Vallet Regí, María | Wiley-VCH Verlag GmbH | 2018Melanoma is one of the most severe public health issues worldwide, not onlybecause of the high number of cases but also for its poor prognosis in late stages. Therefore, early diagnosis and efficient treatment are key toward a future solution. H[...]![]()
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Mas, Núria ; Arcos, Daniel ; Polo, Lorena ; Aznar, Elena ; Sánchez Salcedo, Sandra ; Sancenón, Félix ; García Fontecha, Ana ; Marcos Vega, M. Dolores ; Baeza, Alejandro ; Vallet Regí, María ; Martínez-Máñez, Ramón | Wiley-VCH | 2014A new approach towards the design of “gated scaffolds” based on the combination of capped mesoporous silica nanoparticles (MSNs) with porous biomaterials is reported. Using this approach, a 3D gelatin-based scaffold able to selectively deliver c[...]