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Autor Baeza, Alejandro |
Documentos disponibles escritos por este autor (28)
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Martínez, Angel ; Fuentes Paniagua, Elena ; Baeza, Alejandro ; Sánchez Nieves, Javier ; Cicuendez, Monica ; Gómez, Rafael ; Mata, F. Javier de la ; González, Blanca ; Vallet Regí, María | Wiley | 2015-09-15A novel nanosystem based on mesoporous silica nanoparticles covered with carbosilane dendrons grafted on the external surface of the nanoparticles is reported. This system is able to transport single-stranded oligonucleotide into cells, avoiding[...]![]()
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Martínez Carmona, Marina ; Baeza, Alejandro ; Rodriguez Milla, Miguel A. ; García Castro, Javier ; Vallet Regí, María | Royal Society of Chemistry | 2015-06-05A novel phototriggered drug delivery nanocarrier, which exhibits very high tumor cytotoxicity against human tumoral cells, is presented. This device is based on mesoporous silica nanoparticles decorated with a biocompatible protein shell cleavab[...]![]()
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Villaverde, Gonzalo ; Alfranca, Arantzazú ; González-Murillo, África ; Melen, Gustavo J. ; Castillo, Rafael R. ; Ramírez, Manuel ; Baeza, Alejandro ; Vallet Regí, María | Wiley-VCH | 2018-12-10The selective delivery of therapeutic and imaging agents to tumoral cells has been postulated as some of the most important challenges in nanomedicine field. The cellular selectivity of nanocarriers is usually achieved by their surface decoratio[...]![]()
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The development of nanomachines able to operate at the nanoscale, performing complex tasks such as drug delivery, precision surgery, or cell detection, constitutes one of the most important challenges in nanotechnology. The principles that rule [...]![]()
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The use of therapeutic proteins plays a fundamental role in the treatment of numerous diseases. The low physico-chemical stability of proteins in physiological conditions put their function at risk in the human body until they reach their target[...]![]()
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Villaverde, Gonzalo ; Baeza, Alejandro ; Melen, Gustavo J. ; Alfranca, Arantzazú ; Ramírez, Manuel ; Vallet Regí, María | Royal Society of Chemistry | 2015-04-14Novel targeting agents against neuroblastoma based on the meta-iodobenzylguanidine (MIBG) moiety were synthesized and biologically evaluated for nanocarrier vectorization. These compounds have been anchored on the surface of drug loaded mesoporo[...]![]()
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Martínez Carmona, Marina ; Lozano Borregón, Daniel ; Baeza, Alejandro ; Colilla, Montserrat ; Vallet Regí, María | Royal Society of Chemistry | 2017-09-19A novel singlet-oxygen sensitive drug delivery nanocarrier able to release their cargo after exposure to visible (Vis) light of a common lamp is presented. This nanodevice is based on mesoporous silica nanoparticles (MSN) decorated with porphyri[...]![]()
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Introduction: Stimuli-responsive nanomaterials for cancer therapy have attracted much interest recently due to their potential for improving the current standard of care. Different types of inorganic nanoparticles are widely employed for the dev[...]![]()
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The poor penetration of drug nanocarriers within tumor tissues is one of the most critical factors which limit their effectiveness. Nanomedicine has developed different strategies in order to overcome this important hurdle. Some of these strateg[...]![]()
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Introduction: Nanotechnology has provided new tools for addressing unmet clinical situations, especially in the oncology field. The development of smart nanocarriers able to deliver chemotherapeutic agents specifically to the diseased cells and [...]![]()
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Castillo Romero, Rafael ; Baeza, Alejandro ; Vallet Regí, María | Royal Society of Chemistry | 2017-01-20The discovery and control of the biological roles mediated by nucleic acids have turned them into a powerful tool for the development of advanced biotechnological materials. Much is the importance of those gene-keeping biomacromolecules that eve[...]![]()
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Villaverde, Gonzalo ; Gómez-Graña, Sergio ; Guisasola, Eduardo ; García, Isabel ; Hanske, Cristoph ; Liz-Marzan, Luis M ; Baeza, Alejandro ; Vallet Regí, María | Wiley-VCH Verlag GmbH | 2018Melanoma is one of the most severe public health issues worldwide, not onlybecause of the high number of cases but also for its poor prognosis in late stages. Therefore, early diagnosis and efficient treatment are key toward a future solution. H[...]![]()
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Mas, Núria ; Arcos, Daniel ; Polo, Lorena ; Aznar, Elena ; Sánchez Salcedo, Sandra ; Sancenón, Félix ; García Fontecha, Ana ; Marcos Vega, M. Dolores ; Baeza, Alejandro ; Vallet Regí, María ; Martínez-Máñez, Ramón | Wiley-VCH | 2014A new approach towards the design of “gated scaffolds” based on the combination of capped mesoporous silica nanoparticles (MSNs) with porous biomaterials is reported. Using this approach, a 3D gelatin-based scaffold able to selectively deliver c[...]