Información del autor
Documentos disponibles escritos por este autor (28)
Añadir el resultado a su cesta Hacer una sugerencia Refinar búsqueda
texto impreso
Baeza, Alejandro ; Colilla, Montserrat ; Varas Muriel, María José ; Vallet Regí, María | Informa Healthcare | 2015Mesoporous silica nanoparticles (MSNPs)are one of the most promising inorganic drug delivery systems(DDSs). The design and development of tumour-targeted MSNPs with stimuli-responsive drug release capability aim at enhancing the efficiency and m[...]texto impreso
Moreno Zafra, Víctor Manuel ; Alvarez Corchado, Elena ; Izquierdo-Barba, Isabel ; Baeza, Alejandro ; Serrano López, Juana ; Vallet Regí, María | Wiley Online Library | 2020-04-21One of the major concerns in the application of nanocarriers in oncology is their scarce penetration capacity in tumoral tissues, which drastically compromises the effectivity. Living organisms as cells and bacteria present the capacity to navig[...]texto impreso
Guisasola, Eduardo ; Asin, Laura ; Beola, Lillianne ; De la Fuente, J. M. ; Baeza, Alejandro ; Vallet Regí, María | American Chemical Society | 2018-03-21In this study we present an innovation in the tumor treatment in vivo mediated by magnetic mesoporous silica nanoparticles (MMSNs). This device was built with iron oxide magnetic nanoparticles embedded in a mesoporous silica matrix and coated wi[...]texto impreso
Villegas, Maria Rocio ; Baeza, Alejandro ; Usategui Corral, Alicia ; Ortiz-Romero, Pablo L. ; Pablos, J. L. ; Vallet Regí, María | Elsevier | 2018-05-03Fibrosis is a common lesion in different pathologic diseases and de?ned by the excessive accumulation ofcollagen. Different approaches have been used to treat different conditions characterized by ?brosis. TheFDA and EMA approved the use of coll[...]texto impreso
Villegas Díaz, María Rocío ; Baeza, Alejandro ; Usategui Corral, Alicia ; Ortiz-Romero, Pablo L. ; Pablos, José L. ; Vallet Regí, María | Elsevier | 2018-05-04Fibrosis is a common lesion in different pathologic diseases and defined by the excessive accumulation of collagen. Different approaches have been used to treat different conditions characterized by fibrosis. The FDA and EMA approved the use of [...]texto impreso
Guisasola, Eduardo ; Baeza, Alejandro ; Talelli, Marina ; Arcos Navarrete, Daniel ; Vallet Regí, María | Royal Society of Chemistry | 2016-04-25Stimuli-responsive devices are novel tools widely studied in the nanomedicine research field. In this work, magnetic-responsive mesoporous silica nanoparticles (MMSNs) were coated with an engineered thermoresponsive co-polymer. Magnetic cores ar[...]texto impreso
Villaverde Cantizano, Gonzalo ; Nairi, Valentina ; Baeza, Alejandro ; Vallet Regí, María | Wiley | 2017-03-28The selective transportation of therapeutic agents to tumoral cells is usually achieved by their conjugation with targeting moieties able to recognize these cells. Unfortunately, simple and static targeting systems usually show selectivity lacks[...]texto impreso
Vallet Regí, María ; Salinas Sánchez, Antonio J. ; Baeza, Alejandro ; Manzano García, Miguel | Elsevier | 2018-05-15texto impreso
One of the major limitations of nanomedicine is the scarce penetration of nanoparticles in tumoral tissues. These constrains have been tried to be solved by different strategies, such as the employ of polyethyleneglycol (PEG) to avoid the opsoni[...]texto impreso
Guisasola, Eduardo ; Baeza, Alejandro ; Asin, Laura ; De la Fuente, J. M. ; Vallet Regí, María | Wiley-Blackwell | 2018-05-07Nanocarriers for cancer therapy have been extensively studied, but there is still some research that must be addressed in order to achieve their safe application. In this field, hyperthermia thermal treatments mediated by the us of responsive na[...]texto impreso
Villegas Díaz, María Rocío ; Baeza, Alejandro ; Vallet Regí, María | American Chemical Society | 2015-11-04Poor penetration of drug delivery nanocarriers within dense extracellular matrices constitutes one of the main liabilities of current nanomedicines. The conjugation of proteolytic enzymes on the nanoparticle surface constitutes an attractive alt[...]texto impreso
Hybrid Enzyme-Polymeric Capsules/Mesoporous Silica Nanodevice for In Situ Cytotoxic Agent Generation
Baeza, Alejandro ; Guisasola, Eduardo ; Torres Pardo, Almudena ; González Calbet, José M. ; Melen, Gustavo J. ; Ramírez, Manuel ; Vallet Regí, María | Wiley | 2014-08-06A novel nanocarrier based on functionalized mesoporous silica nanoparticles able to transport a non-toxic pro-drug and the enzyme responsible for its activation is presented. This nanodevice is able to generate in situ cytotoxic species once acc[...]texto impreso
Simmchen, Juliane ; Baeza, Alejandro ; Ruiz-Molina, Daniel ; Vallet Regí, María | Royal Society of Chemistry | 2014-06-03Biocatalytic propulsion is expected to play an important role in the future of micromotors as it might drastically increase the number of available fuelling reactions. However, most of the enzyme-propelled micromotors so far reported still rely [...]texto impreso
Lopez, Victoria ; Villegas, Maria Rocio ; Rodriguez, Veronica ; Villaverde, Gonzalo ; Lozano, Daniel ; Baeza, Alejandro ; Vallet Regí, María | ACS | 2017-07-31The development of targeted nanocarriers able to be selectively internalized within tumor cells, and therefore to deliver anti-tumor drugs specifically to diseased cells, constitutes one of the most important goals in nano-oncology. Herein, the [...]texto impreso
Nanoparticles have become a powerful tool in oncology not only as carrier of the highly toxic chemotherapeutic drugs but also as imaging contrast agents that provide valuable information about the state of the disease and its progression. The en[...]
