Información del autor
Documentos disponibles escritos por este autor (55)
Añadir el resultado a su cesta Hacer una sugerencia Refinar búsqueda
texto impreso
Alegre Cebollada, Jorge ; Cunietti, Michela ; Herrero Galán, Elías ; Gavilanes, José G. ; Martínez del Pozo, Álvaro | Elsevier | 2008-08The mechanisms by which pore-forming toxins are able to insert into lipid membranes are a subject of the highest interest in the field of lipid–protein interaction. Eight mutants affecting different regions of sticholysin II, a member of the por[...]texto impreso
Olombrada, Miriam ; Medina, Pilar ; Budia, Flor ; Gavilanes, José G. ; Martínez del Pozo, Álvaro ; García Ortega, Lucía | De Gruyter | 2016-09Metarhizium anisopliae is an entomopathogenic fungus relevant in biotechnology with applications like malaria vector control. Studies of its virulence factors are therefore of great interest. Fungal ribotoxins are toxic ribonucleases with extr[...]texto impreso
Olombrada, Miriam ; Medina, Pilar ; Budia, Flor ; Gavilanes, José ; Martínez del Pozo, Álvaro ; García Ortega, Lucía | De Gruyter | 2017-01-01Metarhizium anisopliae is an entomopathogenic fungus relevant in biotechnology with applications like malaria vector control. Studies of its virulence factors are therefore of great interest. Fungal ribotoxins are toxic ribonucleases with extrao[...]texto impreso
Alm, Ida ; García Linares, Sara ; Gavilanes, José G. ; Martínez del Pozo, Álvaro ; Slotte, J. Peter | Elsevier | 2015-04The pore forming capacity of Sticholysin II (StnII; isolated from Stichodactyla helianthus) in bilayer membranes containing 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC), palmitoylsphingomyelin (PSM) and either cholesterol or palmitoyl[...]texto impreso
Álvarez García, Elisa ; Batanero Cremades, Eva ; García Fernández, Rosa ; Villalba Díaz, María Teresa ; Gavilanes, José G. ; Martínez del Pozo, Álvaro | Esmon Publicidad | 2010-03?-Sarcin is a natural variant of Asp f 1 produced by the nonpathogenic fungus Aspergillus giganteus. Both proteins show a sequence identity of 87% and almost identical 3-dimensional structures. ?-Sarcin ?(7-22) is a deletion mutant that displays[...]texto impreso
Lázaro Gorines, Rodrigo ; López Rodríguez, Juan Carlos ; Benedé, Sara ; González, Miguel ; Mayorga, Cristobalina ; Vogel, Lothar ; Martínez del Pozo, Álvaro ; Lacadena, Javier ; Villalba, Mayte | Nature Research | 2020-07-23Immunotoxins appear as promising therapeutic molecules, alternative to allergen-specifcimmunotherapy. In this work, we achieved the development of a protein chimera able to promote specifc cell death on efector cells involved in the allergic rea[...]texto impreso
Palacios Ortega, Juan ; García Linares, Sara ; Rivera de la Torre, Esperanza ; Gavilanes, José G. ; Martínez del Pozo, Álvaro ; Slotte, J. Peter | ACS | 2017In this study, we examined the influence of bilayer thickness on the activity of the actinoporin toxins sticholysin I and II (StnI and StnII) at 25 °C. Bilayer thickness was varied using dimonounsaturated phosphatidylcholine (PC) analogues (with[...]texto impreso
García-Linares, Sara ; Rivera de la Torre, Esperanza ; Morante, Koldo ; Tsumoto, Kouhei ; Caaveiro, José M. M. ; Gavilanes, José G. ; Slotte, J. Peter ; Martínez del Pozo, Álvaro | American Chemical Society | 2016-11Sea anemone actinoporins constitute a protein family of multigene pore-forming toxins (PFT). Equinatoxin II (EqtII), fragaceatoxin C (FraC), and sticholysins I and II (StnI and StnII, respectively), produced by three different sea anemone specie[...]texto impreso
Tomé Amat, Jaime ; Olombrada Sacristán, Miriam ; Ruiz de la Herrán, Javier ; Pérez Gómez, Eduardo ; Andradas Arias, Clara ; Sánchez García, Cristina ; Martínez, Leopoldo ; Martínez del Pozo, Álvaro ; Gavilanes, José G. ; Lacadena, Javier | Elsevier | 2015-04Tagging of RNases, such as the ribotoxin ?-sarcin, with the variable domains of antibodies directed to surface antigens that are selectively expressed on tumor cells endows cellular specificity to their cytotoxic action. A recombinant single-cha[...]texto impreso
Hace aproximadamente 50 años Christian B. Anfinsen llevaba a cabo una serie de experimentos que resultaron ser contribuciones esenciales para la comprensión del fenómeno del plegamiento de proteínas. Los resultados obtenidos le permitieron propo[...]texto impreso
Palacios Ortega, Juan ; Rivera-de-Torre, Esperanza ; Gavilanes, José G. ; Slotte, J. Peter ; Martínez del Pozo, Álvaro | Elsevier | 2020-04-21Release of aqueous contents from model lipid vesicles has been a standard procedure to evaluate pore formation efficiency by actinoporins, such as sticholysin II (StnII), for the last few decades. However, regardless of the probe of choice, the [...]texto impreso
Palacios Ortega, Juan ; Rivera de la Torre, Esperanza ; Gavilanes, José G. ; Slotte, J. Peter ; Martínez del Pozo, Álvaro | Elsevier | 2020-09-01Release of aqueous contents from model lipid vesicles has been a standard procedure to evaluate pore formation efficiency by actinoporins, such as sticholysin II (StnII), for the last few decades. However, regardless of the probe of choice, the [...]texto impreso
Rivera de la Torre, Esperanza ; Palacios Ortega, Juan ; Slotte, J. Peter ; Gavilanes, José G. ; Martínez del Pozo, Álvaro ; García Linares, Sara | MDPI | 2020-11Venoms constitute complex mixtures of many different molecules arising from evolution in processes driven by continuous prey–predator interactions. One of the most common compounds in these venomous cocktails are pore-forming proteins, a family [...]texto impreso
Olombrada Sacristán, Miriam ; Herrero Galán, Elías ; Tello, Daniel ; Oñaderra Sánchez, Mercedes ; Gavilanes, José G. ; Martínez del Pozo, Álvaro ; García Ortega, Lucía | Elsevier | 2013Fungal ribotoxins were discovered almost 50 years ago as extracellular ribonucleases (RNases) with antitumoral properties. However, the biological function of these toxic proteins has remained elusive. The discovery of the ribotoxin HtA, produce[...]texto impreso
García Ortega, Lucía ; Palacios Ortega, Juan ; Martínez del Pozo, Álvaro | Wiley Online Library | 2018-02-16Fungal ribotoxins constitute a family of extracellular ribonucleases with exquisite specificity against rRNA (ribonucleic acid). They induce apoptotic death of cells after inhibiting protein translation. Ribosomes become functionally incompetent[...]
