Información del autor
Autor Martínez del Pozo, Álvaro |
Documentos disponibles escritos por este autor (55)
texto impreso
Alegre Cebollada, Jorge ; Cunietti, Michela ; Herrero Galán, Elías ; Gavilanes, José G. ; Martínez del Pozo, Álvaro | Elsevier | 2008-08The mechanisms by which pore-forming toxins are able to insert into lipid membranes are a subject of the highest interest in the field of lipid–protein interaction. Eight mutants affecting different regions of sticholysin II, a member of the por[...]texto impreso
Olombrada, Miriam ; Medina, Pilar ; Budia, Flor ; Gavilanes, José G. ; Martínez del Pozo, Álvaro ; García Ortega, Lucía | De Gruyter | 2016-09Metarhizium anisopliae is an entomopathogenic fungus relevant in biotechnology with applications like malaria vector control. Studies of its virulence factors are therefore of great interest. Fungal ribotoxins are toxic ribonucleases with extr[...]texto impreso
Olombrada, Miriam ; Medina, Pilar ; Budia, Flor ; Gavilanes, José ; Martínez del Pozo, Álvaro ; García Ortega, Lucía | De Gruyter | 2017-01-01Metarhizium anisopliae is an entomopathogenic fungus relevant in biotechnology with applications like malaria vector control. Studies of its virulence factors are therefore of great interest. Fungal ribotoxins are toxic ribonucleases with extrao[...]texto impreso
Alm, Ida ; García Linares, Sara ; Gavilanes, José G. ; Martínez del Pozo, Álvaro ; Slotte, J. Peter | Elsevier | 2015-04The pore forming capacity of Sticholysin II (StnII; isolated from Stichodactyla helianthus) in bilayer membranes containing 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC), palmitoylsphingomyelin (PSM) and either cholesterol or palmitoyl[...]texto impreso
Álvarez García, Elisa ; Batanero Cremades, Eva ; García Fernández, Rosa ; Villalba Díaz, María Teresa ; Gavilanes, José G. ; Martínez del Pozo, Álvaro | Esmon Publicidad | 2010-03?-Sarcin is a natural variant of Asp f 1 produced by the nonpathogenic fungus Aspergillus giganteus. Both proteins show a sequence identity of 87% and almost identical 3-dimensional structures. ?-Sarcin ?(7-22) is a deletion mutant that displays[...]texto impreso
Lázaro Gorines, Rodrigo ; López Rodríguez, Juan Carlos ; Benedé, Sara ; González, Miguel ; Mayorga, Cristobalina ; Vogel, Lothar ; Martínez del Pozo, Álvaro ; Lacadena, Javier ; Villalba, Mayte | Nature Research | 2020-07-23Immunotoxins appear as promising therapeutic molecules, alternative to allergen-specifcimmunotherapy. In this work, we achieved the development of a protein chimera able to promote specifc cell death on efector cells involved in the allergic rea[...]texto impreso
Palacios Ortega, Juan ; García Linares, Sara ; Rivera de la Torre, Esperanza ; Gavilanes, José G. ; Martínez del Pozo, Álvaro ; Slotte, J. Peter | ACS | 2017In this study, we examined the influence of bilayer thickness on the activity of the actinoporin toxins sticholysin I and II (StnI and StnII) at 25 °C. Bilayer thickness was varied using dimonounsaturated phosphatidylcholine (PC) analogues (with[...]texto impreso
García-Linares, Sara ; Rivera de la Torre, Esperanza ; Morante, Koldo ; Tsumoto, Kouhei ; Caaveiro, José M. M. ; Gavilanes, José G. ; Slotte, J. Peter ; Martínez del Pozo, Álvaro | American Chemical Society | 2016-11Sea anemone actinoporins constitute a protein family of multigene pore-forming toxins (PFT). Equinatoxin II (EqtII), fragaceatoxin C (FraC), and sticholysins I and II (StnI and StnII, respectively), produced by three different sea anemone specie[...]texto impreso
Tomé Amat, Jaime ; Olombrada Sacristán, Miriam ; Ruiz de la Herrán, Javier ; Pérez Gómez, Eduardo ; Andradas Arias, Clara ; Sánchez García, Cristina ; Martínez, Leopoldo ; Martínez del Pozo, Álvaro ; Gavilanes, José G. ; Lacadena, Javier | Elsevier | 2015-04Tagging of RNases, such as the ribotoxin ?-sarcin, with the variable domains of antibodies directed to surface antigens that are selectively expressed on tumor cells endows cellular specificity to their cytotoxic action. A recombinant single-cha[...]texto impreso
Hace aproximadamente 50 años Christian B. Anfinsen llevaba a cabo una serie de experimentos que resultaron ser contribuciones esenciales para la comprensión del fenómeno del plegamiento de proteínas. Los resultados obtenidos le permitieron propo[...]texto impreso
Palacios Ortega, Juan ; Rivera-de-Torre, Esperanza ; Gavilanes, José G. ; Slotte, J. Peter ; Martínez del Pozo, Álvaro | Elsevier | 2020-04-21Release of aqueous contents from model lipid vesicles has been a standard procedure to evaluate pore formation efficiency by actinoporins, such as sticholysin II (StnII), for the last few decades. However, regardless of the probe of choice, the [...]texto impreso
Palacios Ortega, Juan ; Rivera de la Torre, Esperanza ; Gavilanes, José G. ; Slotte, J. Peter ; Martínez del Pozo, Álvaro | Elsevier | 2020-09-01Release of aqueous contents from model lipid vesicles has been a standard procedure to evaluate pore formation efficiency by actinoporins, such as sticholysin II (StnII), for the last few decades. However, regardless of the probe of choice, the [...]texto impreso
Rivera de la Torre, Esperanza ; Palacios Ortega, Juan ; Slotte, J. Peter ; Gavilanes, José G. ; Martínez del Pozo, Álvaro ; García Linares, Sara | MDPI | 2020-11Venoms constitute complex mixtures of many different molecules arising from evolution in processes driven by continuous prey–predator interactions. One of the most common compounds in these venomous cocktails are pore-forming proteins, a family [...]texto impreso
Olombrada Sacristán, Miriam ; Herrero Galán, Elías ; Tello, Daniel ; Oñaderra Sánchez, Mercedes ; Gavilanes, José G. ; Martínez del Pozo, Álvaro ; García Ortega, Lucía | Elsevier | 2013Fungal ribotoxins were discovered almost 50 years ago as extracellular ribonucleases (RNases) with antitumoral properties. However, the biological function of these toxic proteins has remained elusive. The discovery of the ribotoxin HtA, produce[...]texto impreso
García Ortega, Lucía ; Palacios Ortega, Juan ; Martínez del Pozo, Álvaro | Wiley Online Library | 2018-02-16Fungal ribotoxins constitute a family of extracellular ribonucleases with exquisite specificity against rRNA (ribonucleic acid). They induce apoptotic death of cells after inhibiting protein translation. Ribosomes become functionally incompetent[...]texto impreso
Lacadena, Javier ; Álvarez García, Elisa ; Carreras Sangrà, Nelson ; Herrero Galán, Elías ; Alegre Cebollada, Jorge ; García Ortega, Lucía ; Oñaderra, Mercedes ; Gavilanes, José G. ; Martínez del Pozo, Álvaro | 2007RNase T1 is the best known representative of a large family of ribonucleolytic proteins secreted by fungi, mostly Aspergillus and Penicillium species. Ribotoxins stand out among them by their cytotoxic character. They exert their toxic action by[...]texto impreso
Olombrada, Miriam ; Lázaro Gorines, Rodrigo ; López Rodríguez, Juan C. ; Martínez del Pozo, Álvaro ; Oñaderra, Mercedes ; Maestro López, Moisés ; Lacadena, Javier ; Gavilanes, José G. ; García Ortega, Lucía | MDPI | 2017Fungi establish a complex network of biological interactions with other organisms in nature. In many cases, these involve the production of toxins for survival or colonization purposes. Among these toxins, ribotoxins stand out as promising candi[...]texto impreso
Herrero Galán, Elías ; Álvarez García, Elisa ; Carreras Sangrà, Nelson ; Lacadena, Javier ; Alegre Cebollada, Jorge ; Martínez del Pozo, Álvaro ; Oñaderra, Mercedes ; Gavilanes, José G. | Caister Academic Press | 2009Ribotoxins are a family of fungal extracellular ribonucleases which inactivate ribosomes by specifically cleaving a single phosphodiester bond located at the universally conserved sarcin/ricin loop of the large rRNA. The subsequent inhibition of[...]texto impreso
Herrero Domínguez, Santiago ; Martínez del Pozo, Álvaro ; Mancheño Real, María José ; Osío Barcina, José de Jesús ; Nacenta Torres, Pablo ; Bárcena Espelleta, Araceli ; Rubio Lago, Luis ; Álvarez Serrano, Inmaculada ; Cortés Gil, Raquel ; González Prieto, Rodrigo ; Torrecilla Manresa, Sofía ; Cilleros Prados, Olga ; Sobrino Díaz, María Lourdes ; Bartolomé Vílchez, Javier ; Cortijo Montes, Miguel ; Coloma Manjón-Cabeza, Isabel ; Catalán Torrecilla, Cristina ; Guerrero Martínez, Andrés ; Martínez Madrid, Carmen Belén ; Mártínez Ruiz, María Paloma ; Méndez Pozo, Gonzalo Rubén ; Priego Bermejo, José Luis ; Ranchal Sánchez, Rocío ; Maestre Varea, David ; Desvoyes, Benedicte ; Gutiérrez Franco, Yanna María ; Arribas Fernández, Paula ; Julián Cortés, Alvaro | 2020-07-01I.amAble ha ofrecido a estudiantes universitarios de física, química, veterinaria, biología y educación la oportunidad de complementar su formación mediante el diseño, la realización y la evaluación de talleres científicos que faciliten la inclu[...]texto impreso
Herrero Domínguez, Santiago ; Álvarez Serrano, Inmaculada ; Barba Fernández, Carmen ; Cilleros Prados, Olga ; Corrales Castellanos, María Eugenia ; Criado Portal, Antonio José ; Gómez Castro, Emilio ; Gómez de Salazar Caso de los Cobos, José María ; González Prieto, Rodrigo ; Guerrero Martínez, Andrés ; Hernández Díaz, María Yolanda ; Jiménez Aparicio, Reyes ; Lobato Fernández, Álvaro ; Mancheño Real, Mª José ; Mena Fernández, María Luz ; Martínez del Pozo, Álvaro ; Muñoz Olivas, Riansares ; Osío Barcina, José de Jesús ; Priego Bermejo, José Luis ; Rodríguez Vega, Sergio ; Sánchez Arroyo, Antonio José ; Sánchez Benítez, Javier ; Sobrino Díaz, Lourdes ; Taravillo Corralo, Mercedes ; Pastor Gil, Lorena ; Rubianes Méndez, Miguel Alejandro ; Maestre Varea, David ; Ranchal Sánchez, Rocío ; Bautista Blasco, Susana ; Cárdenas Bonet, Marlon ; Gervás Gómez-Navarro, Pablo ; Méndez Pozo, Gonzalo ; Bárcena Espelleta, Araceli ; Desvoyes, Benedicte ; Fernández Rodríguez, Juan Miguel ; Gibaja Jiménez, Mariano ; Nacenta Torres, Pablo ; Rubio Lago, Luis | 2018-07-02En este proyecto de innovación se persigue enriquecer la formación de los estudiantes de las facultades de ciencias (F. CC.FF. y F. CC.QQ.) mediante una propuesta teórico-práctica basada en la metodología Aprendizaje-Servicio (ApS) y encaminada [...]texto impreso
Herrero Domínguez, Santiago ; Herrero Ansorregui, Irene ; Martín Rodríguez, Pablo ; Merí Bofí, Laura ; Sobrino Gómez-Escalonilla, Inés ; Valentín Pérez, Ángela ; Azor Lafarga, Alberto ; Calderón Saturio, Delia ; Cilleros Prados, Olga ; Hernández Díaz, Yolanda ; Molero García, Julián ; Sobrino Díaz, Lourdes ; González Cortés, Araceli ; Mena Fernández, María Luz ; Muñoz Olivas, Riansares ; Martínez del Pozo, Álvaro ; González Prieto, Rodrigo ; Jiménez Aparicio, Reyes ; Priego Bermejo, José Luis ; Varela Losada, Áurea ; Mancheño Real, María José ; Osío Barcina, José ; Guerrero Martínez, Andrés ; Cabañas Poveda, Albertina ; Bautista Blasco, Susana ; Gervás Gómez-Navarro, Pablo ; González Acebrón, Laura ; Méndez Pozo, Gonzalo ; Pavón Mestras, Juan ; Desvoyes, Benedicte ; Landa Cánovas, Ángel ; Fernández Rodríguez, Juan Miguel ; Perles Hernáez, Josefina | 2017-06-30En este proyecto de innovación, que nace con vocación de continuar en años sucesivos, se persigue mejorar la calidad de la formación de los estudiantes de la Facultad de Ciencias Químicas (F. CC.QQ.) en el ámbito de la docencia teórico-práctica [...]texto impreso
Herrero Domínguez, Santiago ; Corrales Castellanos, María Eugenia ; Sobrino Díaz, María Lourdes ; Cilleros Prados, Olga ; Barba Fernández, Carmen ; Azor Lafarga, Alberto Eduardo ; Hernández Díaz, María Yolanda ; Martínez del Pozo, Álvaro ; Ranchal Sánchez, Rocío ; Maestre Varea, David ; Méndez Pozo, Gonzalo Rubén ; Gervás Gómez-Navarro, Pablo ; Pastor Gil, Lorena ; Taravillo Corralo, Mercedes ; Guerrero Martínez, Andrés ; Sánchez Benítez, Francisco Javier ; Martín Conde, María ; Priego Bermejo, José Luis ; González Prieto, Rodrigo ; Jiménez Aparicio, Reyes ; Álvarez Serrano, Inmaculada ; Cortés Gil, Raquel ; Osío Barcina, José de Jesús ; Mancheño Real, María José ; Arribas Fernández, Paula ; Lobato Fernández, Álvaro ; Sánchez Arroyo, Antonio José ; Torrecilla Manresa, Sofía ; Cárdenas Bonett, Marlón Félix ; Desvoyes, Benedicte ; Bárcena Espelleta, Araceli ; Nacenta Torres, Pablo ; Rubio Lago, Luis ; Bautista Blasco, Susana ; Julián Cortés, Alvaro ; Arancibia Llaneza, Julieta Noelia ; Lombraña Pascual, Rodrigo ; Catalán Torrecilla, Cristina ; Gutiérrez Franco, Yanna María ; Mártínez Ruiz, María Paloma | 2019-08-20I.amAble es un proyecto que nació con una filosofía centrada en la utilización de acciones de solidaridad como método de aprendizaje. Se diseñan y organizan talleres científicos inclusivos para realizarlos en parejas formadas por personas con di[...]texto impreso
Álvarez García, Elisa ; García Ortega, Lucía ; De los Ríos, Vivian ; Gavilanes, José G. ; Martínez del Pozo, Álvaro | 2009Ribonuclease U2, secreted by the smut fungus Ustilago sphaerogena, is a cyclizing ribonuclease that displays a rather unusual specificity within the group of microbial extracellular RNases, best represented by RNase T1. Superposition of the thre[...]texto impreso
Alegre Cebollada, Jorge ; Martínez del Pozo, Álvaro ; Gavilanes, José G. ; Goormaghtigh, Erik | 2007-11The structure of the actinoporin sticholysin II (StnII) in the pore state was investigated by Fourier transform infrared spectroscopy in the attenuated total reflection configuration. 1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine/cholesterol [...]texto impreso
Olombrada, Miriam ; García Ortega, Lucía ; Lacadena, Javier ; Oñaderra, Mercedes ; Gavilanes, José G. ; Martínez del Pozo, Álvaro | De Gruyter | 2015-11Ribotoxins are cytotoxic members of the family of fungal extracellular ribonucleases best represented by RNase T1. They share a high degree of sequence identity and a common structural fold, including the geometric arrangement of their active si[...]