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Autor Martínez del Pozo, Álvaro |
Documentos disponibles escritos por este autor (55)
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Olombrada, Miriam ; García Ortega, Lucía ; Lacadena, Javier ; Oñaderra, Mercedes ; Gavilanes, José G. ; Martínez del Pozo, Álvaro | De Gruyter | 2016Ribotoxins are cytotoxic members of the family of fungal extracellular ribonucleases best represented by RNase T1. They share a high degree of sequence identity and a common structural fold, including the geometric arrangement of their active si[...]![]()
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Castaño Rodríguez, Carlos ; Olombrada Sacristán, Miriam ; Partida Hanon, Angélica ; Lacadena García-Gallo, Javier ; Oñaderra Sánchez, Mercedes ; Gavilanes, José G. ; García Ortega, Lucía ; Martínez del Pozo, Álvaro | Elsevier | 2015Ribotoxins are a family of fungal ribosome-inactivating proteins displaying highly specific ribonucleolytic activity against the sarcin/ricin loop (SRL) of the larger rRNA, with a-sarcin as its best-characterized member. Their toxicity arises fr[...]![]()
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Álvarez García, Elisa ; Alegre Cebollada, Jorge ; Batanero Cremades, Eva ; Monedero, Vicente ; Pérez Martínez, Gaspar ; García Fernández, Rosa ; Gavilanes, José G. ; Martínez del Pozo, Álvaro | 2007-06-25Fungal ribotoxins are a family of extracellular ribonucleases which inhibit protein biosynthesis by inactivating the ribosomes. This inactivation results in the induction of cell death by apoptosis. Ribotoxins show antitumoral properties based o[...]![]()
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Maestro-López, Moisés ; Olombrada, Miriam ; García Ortega, Lucía ; Serrano González, Daniel ; Lacadena, Javier ; Oñaderra, Mercedes ; Gavilanes, José G. ; Martínez del Pozo, Álvaro | Elsevier | 2017-03-07Fungal ribotoxins are highly specific extracellular RNases which cleave a single phosphodiester bond at the ribosomal sarcin-ricin loop, inhibiting protein biosynthesis by interfering with elongation factors. Most ribotoxins show high degree of [...]![]()
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Hernansanz Agustín, Pablo ; Choya Foces, Carmen ; Carregal Romero, Susana ; Ramos, Elena ; Oliva, Tamara ; Villa Piña, Tamara ; Moreno, Laura ; Izquierdo Alvarez, Alicia ; Cabrera Garcia, J.Daniel ; Cortés, Ana ; Lechuga Vieco, Ana Victoria ; Jadiya, Pooja ; Navarro, Elisa ; Parada, Esther ; Palomino Antolín, Alejandra ; Tello, Daniel ; Acín Pérez, Rebeca ; Rodríguez Aguilera, Juan Carlos ; Navas, Plácido ; Cogolludo, Angel ; López Montero, Iván ; Martínez del Pozo, Álvaro ; Egea, Javier ; López, Manuela G. ; Elrod, John W. ; Ruiz Cabello, J. ; Bogdanova, Anna ; Enríquez, José Antonio ; Martínez Ruiz, Antonio | Nature Research | 2020-07-29All metazoans depend on O2 delivery and consumption by the mitochondrial oxidative phosphorylation (OXPHOS) system to produce energy. A decrease in O2 availability (hypoxia) leads to profound metabolic rewiring. In addition, OXPHOS uses O2 to pr[...]![]()
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Lázaro Gorines, R. ; Ruiz de la Herrán, J. ; Navarro, R. ; Sanz, L. ; Alvarez Vallina, L. ; Martínez del Pozo, Álvaro ; Gavilanes, José G. ; Lacadena, J. | Nature Research | 2019Immunotoxins are chimeric molecules, which combine antibody specifcity to recognize and bind with high-afnity tumor-associated antigens (TAA) with the potency of the enzymatic activity of a toxin, in order to induce the death of target cells. Cu[...]![]()
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Rivera de Torre, Esperanza ; Palacios Ortega, Juan ; García Linares, Sara ; Gavilanes, José G. ; Martínez del Pozo, Álvaro | Elsevier | 2017-12Sticholysins I and II (StnI and StnII), ?-pore forming toxins from the sea anemone Stichodactyla helianthus, are water-soluble toxic proteins which upon interaction with lipid membranes of specific composition bind to the bilayer, extend and ins[...]![]()
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Rivera de la Torre, Esperanza ; Palacios Ortega, Juan ; Gavilanes, José G. ; Martínez del Pozo, Álvaro ; García Linares, Sara | MDPI | 2019Animal venoms are complex mixtures of highly specialized toxic molecules. Cnidarians and arachnids produce pore-forming proteins (PFPs) directed against the plasma membrane of their target cells. Among PFPs from cnidarians, actinoporins stand ou[...]![]()
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Tomé-Amat, Jaime ; Herrero-Galán, Elías ; Oñaderra, Mercedes ; Martínez del Pozo, Álvaro ; Gavilanes, José G. ; Lacadena, Javier | Wiley | 2015-06Immunotoxins are chimeric proteins composed of an antibody domain that specifically directs the action of the toxic domain, resulting in the death of the targeted cells. Over recent years, immunotoxins have been widely studied and the number of [...]![]()
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López García, Belén ; Moreno, Ana Beatriz ; San Segundo , Blanca ; De los Ríos , Vivian ; Manning, James M. ; Gavilanes, José G. ; Martínez del Pozo, Álvaro | Elsevier | 2010The mould Aspergillus giganteus produces a basic, low molecular weight protein (AFP) showing in vitro and in vivo antifungal properties against important plant pathogens. AFP is secreted as an inactive precursor containing an amino-terminal exte[...]![]()
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Palacios Ortega, Juan ; García Linares, Sara ; Astrand, Mia ; Abdullah Al Sazzad, Md. ; Gavilanes, José G. ; Martínez del Pozo, Álvaro ; Slotte, J. Peter | ACS | 2016Sticholysin II (StnII) is a pore-forming toxin that uses sphingomyelin (SM) as the recognition molecule in targeting membranes.After StnII monomers bind to SM, several toxin monomers act in concert to oligomerize into a functional pore. The regu[...]![]()
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Ribotoxins are a family of toxic extracellular fungal RNases that first enter into the cells and then exert a highly specific ribonucleolytic activity on the larger rRNA molecule, leading to protein synthesis inhibition and cell death by apoptos[...]![]()
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García Linares, Sara ; Maula, Terhi ; Rivera de la Torre, Esperanza ; Gavilanes, José G. ; Slotte, J.Peter ; Martínez del Pozo, Álvaro | American Chemical Society | 2016Actinoporins are pore-forming toxins from sea anemones. Upon interaction with sphingomyelin-containing bilayers, they become integral oligomeric membrane structures that form a pore. Sticholysin II from Stichodactyla helianthus contains five try[...]![]()
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Tomé-Amat, Jaime ; Ruiz de la Herrán, Javier ; Martínez del Pozo, Álvaro ; Gavilanes, José G. ; Lacadena, Javier | Wiley | 2015-04Toxins have been thoroughly studied for their use as therapeutic agents in search of an improvement in toxic efficiency together with a minimization of their undesired side effects. Different studies have shown how toxins can follow different in[...]![]()
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Alegre Cebollada, Jorge ; Oñaderra, Mercedes ; Gavilanes, José G. ; Martínez del Pozo, Álvaro | 2007-12Actinoporins are a family of 20-kDa, basic proteins isolated from sea anemones, whose activity is inhibited by preincubation with sphingomyelin. They are produced in monomeric soluble form but, when binding to the plasma membrane, they oligomeri[...]![]()
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Transcriptomic profiling of venom producing tissues from different animals is an effective approach for discovering new toxins useful in biotechnological and pharmaceutical applications, as well in evolutionary comparative studies of venomous an[...]![]()
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Transcriptomic profiling of venom producing tissues from different animals is an effective approach for discovering new toxins useful in biotechnological and pharmaceutical applications, as well in evolutionary comparative studies of venomous an[...]![]()
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Palacios Ortega, Juan ; García Linares, Sara ; Rivera de la Torre, Esperanza ; Gavilanes, José G. ; Martínez del Pozo, Álvaro ; Slotte, J. Peter | Elsevier | 2019-06-18Actinoporins are a group of soluble toxic proteins that bind to membranes containing sphingomyelin (SM) and oligomerize to form pores. Sticholysin II (StnII) is a member of the actinoporin family, produced by Stichodactyla helianthus. Cholestero[...]![]()
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Rivera de Torre, Esperanza ; Palacios Ortega, Juan ; Garb, Jessica E. ; Slotte, J. Peter ; Gavilanes, José G. ; Martínez del Pozo, Álvaro | Elsevier | 2020Actinoporins are a family of pore-forming toxins produced by sea anemones as part of their venomous cocktail. These proteins remain soluble and stably folded in aqueous solution, but when interacting with sphingomyelin-containing lipid membranes[...]![]()
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Vitale, Stefania ; Partida Hanon, Angélica ; Serrano, Soraya ; Martínez del Pozo, Álvaro ; Di Pietro, Antonio ; Turrà, David ; Bruix, Marta | The American Society for Biochemistry and Molecular Biology | 2017-01During sexual development, ascomycete fungi produce two types of peptide pheromones termed a and ?. The ? pheromone from the budding yeast Saccharomyces cerevisiae, a thirteen residue peptide which elicits cell cycle arrest and chemotropic growt[...]![]()
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Rivera de Torre, Esperanza ; García Linares, Sara ; Alegre Cebollada, Jorge ; Lacadena, Javier ; Gavilanes, José G. ; Martínez del Pozo, Álvaro | American Society for Biochemistry and Molecular Biology | 2016-04-27Among the toxic polypeptides secreted in the venom of sea anemones, actinoporins are pore forming toxins whose toxic activity relies on the formation of oligomeric pores within biological membranes. Intriguingly, actinoporins appear as multigene[...]![]()
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Rivera de la Torre, Esperanza ; García Linares, Sara ; Alegre Cebollada, Jorge ; Lacadena, Javier ; Gavilanes, José G. ; Martínez del Pozo, Álvaro | ASBMB American Society for Biochemistry and Molecular Biology | 2016Among the toxic polypeptides secreted in the venom of sea anemones, actinoporins are the pore-forming toxins whose toxic activity relies on the formation of oligomeric pores within biological membranes. Intriguingly, actinoporins appear as multi[...]![]()
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García Ortega, Lucía ; Alegre Cebollada, Jorge ; García Linares, Sara ; Bruix, Marta ; Martínez del Pozo, Álvaro ; Gavilanes, José G. | Elsevier | 2011-09Actinoporins constitute a group of small and basic ?-pore forming toxins produced by sea anemones. They display high sequence identity and appear as multigene families. They show a singular behaviour at the water-membrane interface: In aqueous s[...]![]()
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García-Linares, Sara ; Alm, Ida ; Maula, Terhi ; Gavilanes, José G. ; Slotte, J. Peter ; Martínez del Pozo, Álvaro | MDPI | 2015Actinoporins are ?-pore forming proteins with therapeutic potential, produced by sea anemones. Sticholysin II (StnII) from Stichodactyla helianthus is one of its most extensively characterized members. These proteins remain stably folded in wate[...]![]()
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García Linares, Sara ; Rivera de la Torre, Esperanza ; Palacios Ortega, Juan ; Gavilanes, José G. ; Martínez del Pozo, Álvaro | Eslsevier | 2017Sea anemones produce venoms containing different toxic molecules. Among them, actinoporins are some of the best characterized ones. They constitute a family of toxic polypeptides that belong to the much larger group of pore-forming toxins. Actin[...]