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Autor Martínez del Pozo, Álvaro |
Documentos disponibles escritos por este autor (55)
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Lázaro Gorines, R. ; Ruiz de la Herrán, J. ; Navarro, R. ; Sanz, L. ; Alvarez Vallina, L. ; Martínez del Pozo, Álvaro ; Gavilanes, José G. ; Lacadena, J. | Nature Research | 2019Immunotoxins are chimeric molecules, which combine antibody specifcity to recognize and bind with high-afnity tumor-associated antigens (TAA) with the potency of the enzymatic activity of a toxin, in order to induce the death of target cells. Cu[...]texto impreso
Rivera de Torre, Esperanza ; Palacios Ortega, Juan ; García Linares, Sara ; Gavilanes, José G. ; Martínez del Pozo, Álvaro | Elsevier | 2017-12Sticholysins I and II (StnI and StnII), ?-pore forming toxins from the sea anemone Stichodactyla helianthus, are water-soluble toxic proteins which upon interaction with lipid membranes of specific composition bind to the bilayer, extend and ins[...]texto impreso
Rivera de la Torre, Esperanza ; Palacios Ortega, Juan ; Gavilanes, José G. ; Martínez del Pozo, Álvaro ; García Linares, Sara | MDPI | 2019Animal venoms are complex mixtures of highly specialized toxic molecules. Cnidarians and arachnids produce pore-forming proteins (PFPs) directed against the plasma membrane of their target cells. Among PFPs from cnidarians, actinoporins stand ou[...]texto impreso
Tomé-Amat, Jaime ; Herrero-Galán, Elías ; Oñaderra, Mercedes ; Martínez del Pozo, Álvaro ; Gavilanes, José G. ; Lacadena, Javier | Wiley | 2015-06Immunotoxins are chimeric proteins composed of an antibody domain that specifically directs the action of the toxic domain, resulting in the death of the targeted cells. Over recent years, immunotoxins have been widely studied and the number of [...]texto impreso
López García, Belén ; Moreno, Ana Beatriz ; San Segundo , Blanca ; De los Ríos , Vivian ; Manning, James M. ; Gavilanes, José G. ; Martínez del Pozo, Álvaro | Elsevier | 2010The mould Aspergillus giganteus produces a basic, low molecular weight protein (AFP) showing in vitro and in vivo antifungal properties against important plant pathogens. AFP is secreted as an inactive precursor containing an amino-terminal exte[...]texto impreso
Palacios Ortega, Juan ; García Linares, Sara ; Astrand, Mia ; Abdullah Al Sazzad, Md. ; Gavilanes, José G. ; Martínez del Pozo, Álvaro ; Slotte, J. Peter | ACS | 2016Sticholysin II (StnII) is a pore-forming toxin that uses sphingomyelin (SM) as the recognition molecule in targeting membranes.After StnII monomers bind to SM, several toxin monomers act in concert to oligomerize into a functional pore. The regu[...]texto impreso
Ribotoxins are a family of toxic extracellular fungal RNases that first enter into the cells and then exert a highly specific ribonucleolytic activity on the larger rRNA molecule, leading to protein synthesis inhibition and cell death by apoptos[...]texto impreso
García Linares, Sara ; Maula, Terhi ; Rivera de la Torre, Esperanza ; Gavilanes, José G. ; Slotte, J.Peter ; Martínez del Pozo, Álvaro | American Chemical Society | 2016Actinoporins are pore-forming toxins from sea anemones. Upon interaction with sphingomyelin-containing bilayers, they become integral oligomeric membrane structures that form a pore. Sticholysin II from Stichodactyla helianthus contains five try[...]texto impreso
Tomé-Amat, Jaime ; Ruiz de la Herrán, Javier ; Martínez del Pozo, Álvaro ; Gavilanes, José G. ; Lacadena, Javier | Wiley | 2015-04Toxins have been thoroughly studied for their use as therapeutic agents in search of an improvement in toxic efficiency together with a minimization of their undesired side effects. Different studies have shown how toxins can follow different in[...]texto impreso
Alegre Cebollada, Jorge ; Oñaderra, Mercedes ; Gavilanes, José G. ; Martínez del Pozo, Álvaro | 2007-12Actinoporins are a family of 20-kDa, basic proteins isolated from sea anemones, whose activity is inhibited by preincubation with sphingomyelin. They are produced in monomeric soluble form but, when binding to the plasma membrane, they oligomeri[...]texto impreso
Transcriptomic profiling of venom producing tissues from different animals is an effective approach for discovering new toxins useful in biotechnological and pharmaceutical applications, as well in evolutionary comparative studies of venomous an[...]texto impreso
Transcriptomic profiling of venom producing tissues from different animals is an effective approach for discovering new toxins useful in biotechnological and pharmaceutical applications, as well in evolutionary comparative studies of venomous an[...]texto impreso
Palacios Ortega, Juan ; García Linares, Sara ; Rivera de la Torre, Esperanza ; Gavilanes, José G. ; Martínez del Pozo, Álvaro ; Slotte, J. Peter | Elsevier | 2019-06-18Actinoporins are a group of soluble toxic proteins that bind to membranes containing sphingomyelin (SM) and oligomerize to form pores. Sticholysin II (StnII) is a member of the actinoporin family, produced by Stichodactyla helianthus. Cholestero[...]texto impreso
Rivera de Torre, Esperanza ; Palacios Ortega, Juan ; Garb, Jessica E. ; Slotte, J. Peter ; Gavilanes, José G. ; Martínez del Pozo, Álvaro | Elsevier | 2020Actinoporins are a family of pore-forming toxins produced by sea anemones as part of their venomous cocktail. These proteins remain soluble and stably folded in aqueous solution, but when interacting with sphingomyelin-containing lipid membranes[...]texto impreso
Vitale, Stefania ; Partida Hanon, Angélica ; Serrano, Soraya ; Martínez del Pozo, Álvaro ; Di Pietro, Antonio ; Turrà, David ; Bruix, Marta | The American Society for Biochemistry and Molecular Biology | 2017-01During sexual development, ascomycete fungi produce two types of peptide pheromones termed a and ?. The ? pheromone from the budding yeast Saccharomyces cerevisiae, a thirteen residue peptide which elicits cell cycle arrest and chemotropic growt[...]