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Autor Martínez del Pozo, Álvaro |
Documentos disponibles escritos por este autor (55)
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Rivera de Torre, Esperanza ; García Linares, Sara ; Alegre Cebollada, Jorge ; Lacadena, Javier ; Gavilanes, José G. ; Martínez del Pozo, Álvaro | American Society for Biochemistry and Molecular Biology | 2016-04-27Among the toxic polypeptides secreted in the venom of sea anemones, actinoporins are pore forming toxins whose toxic activity relies on the formation of oligomeric pores within biological membranes. Intriguingly, actinoporins appear as multigene[...]texto impreso
Rivera de la Torre, Esperanza ; García Linares, Sara ; Alegre Cebollada, Jorge ; Lacadena, Javier ; Gavilanes, José G. ; Martínez del Pozo, Álvaro | ASBMB American Society for Biochemistry and Molecular Biology | 2016Among the toxic polypeptides secreted in the venom of sea anemones, actinoporins are the pore-forming toxins whose toxic activity relies on the formation of oligomeric pores within biological membranes. Intriguingly, actinoporins appear as multi[...]texto impreso
García Ortega, Lucía ; Alegre Cebollada, Jorge ; García Linares, Sara ; Bruix, Marta ; Martínez del Pozo, Álvaro ; Gavilanes, José G. | Elsevier | 2011-09Actinoporins constitute a group of small and basic ?-pore forming toxins produced by sea anemones. They display high sequence identity and appear as multigene families. They show a singular behaviour at the water-membrane interface: In aqueous s[...]texto impreso
García-Linares, Sara ; Alm, Ida ; Maula, Terhi ; Gavilanes, José G. ; Slotte, J. Peter ; Martínez del Pozo, Álvaro | MDPI | 2015Actinoporins are ?-pore forming proteins with therapeutic potential, produced by sea anemones. Sticholysin II (StnII) from Stichodactyla helianthus is one of its most extensively characterized members. These proteins remain stably folded in wate[...]texto impreso
García Linares, Sara ; Rivera de la Torre, Esperanza ; Palacios Ortega, Juan ; Gavilanes, José G. ; Martínez del Pozo, Álvaro | Eslsevier | 2017Sea anemones produce venoms containing different toxic molecules. Among them, actinoporins are some of the best characterized ones. They constitute a family of toxic polypeptides that belong to the much larger group of pore-forming toxins. Actin[...]texto impreso
Álvarez García, Elisa ; Diago Navarro, Elizabeth ; Herrero Galán, Elías ; García Ortega, Lucía ; López Villarejo, Juan ; Olmo López, Nieves ; Díaz Orejas, Ramón ; Gavilanes, José G. ; Martínez del Pozo, Álvaro | Elsevier | 2011Fungal ribotoxins are toxic secreted ribonucleases that cleave a conserved single phosphodiester bond located at the sarcin/ricin loop of the larger rRNA. This cleavage inactivates ribosomes leading to protein biosynthesis inhibition and cell de[...]texto impreso
Olombrada, Miriam ; Peña, Cohue ; Rodríguez Galán, Olga ; Klingauf Nerurkar, Purnima ; Portugal Calisto, Daniela ; Oborská Oplová, Michaela ; Altvater, Martin ; Gavilanes, José G. ; Martínez del Pozo, Álvaro ; De la Cruz, Jesús ; García Ortega, Lucía ; Govind Panse, Vikram | Elsevier | 2020-04-04The ribotoxin -sarcin belongs to a family of ribonucleases that cleave the sarcin/ricin loop (SRL), a critical functional rRNA element within the large ribosomal subunit (60S), thereby abolishing translation. Whether -sarcin targets the SRL only[...]texto impreso
Olombrada, Miriam ; Peña, Cohue ; Rodríguez Galán, Olga ; Klingauf Nerurkar, Purnima ; Portugal Calisto, Daniela ; Oborská Oplová, Michaela ; Altvater, Martin ; Gavilanes, José G. ; Martínez del Pozo, Álvaro ; Cruz, Jesús de la ; García Ortega, Lucía ; Govind Panse, Vikram | Oxford University Press | 2020The ribotoxin -sarcin belongs to a family of ribonucleases that cleave the sarcin/ricin loop (SRL), a critical functional rRNA element within the large ribosomal subunit (60S), thereby abolishing translation. Whether -sarcin targets the SRL only[...]texto impreso
Carreras Sangrà, Nelson ; Álvarez García, Elisa ; Herrero Galán, Elías ; Tomé, Jaime ; Lacadena, Javier ; Alegre Cebollada, Jorge ; Oñaderra, Mercedes ; Gavilanes, José G. ; Martínez del Pozo, Álvaro | Bentham Science Publishers Ltd. | 2008Ribotoxins constitute a family of toxic extracellular fungal RNases that exert a highly specific activity on a conserved region of the larger molecule of rRNA, known as the sarcin–ricin loop. This cleavage of a single phosphodiester bond inactiv[...]texto impreso
García Linares, Sara ; Palacios Ortega, Juan ; Yasuda, Tomokazu ; Astrand, Mia ; Gavilanes, José G. ; Martínez del Pozo, Álvaro ; Slotte, J. Peter | Elsevier | 2016-03-11Sticholysin I and II (StnI and StnII) are pore-forming toxins that use sphingomyelin (SM) for membrane binding. We examined how hydrogen bonding among membrane SMs affected the StnI- and StnII-induced pore formation process, resulting in bilayer[...]