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Castillo, Rafael R. ; Lozano Borregón, Daniel ; González, Blanca ; Manzano García, Miguel ; Izquierdo-Barba, Isabel ; Vallet Regí, María | Taylor & Francis | 2019-03-22Introduction: Mesoporous silica nanoparticles (MSNs) are outstanding nanoplatforms for drug delivery. Herein, the most recent advances to turn MSN-based carriers into minimal side effect drug delivery agents are covered. Areas covered: This revi[...]texto impreso
Vallet Regí, María ; Lozano Borregón, Daniel ; González Ortiz, Blanca ; Izquierdo-Barba, Isabel | Wiley Online Library | 2020-05-26Chronic bone infection is considered as one of the most problematic biofilm-related infections. Its recurrent and resistant nature, high morbidity,prolonged hospitalization, and costly medical care expenses have driven the efforts of the scien[...]texto impreso
Castillo, Rafael R. ; Lozano Borregón, Daniel ; Vallet Regí, María | American Chemical Society | 2018-10-01ABSTRACT: Despite encapsulation of drugs claim to improve the therapeutic profile of free drugs, there are still important limitations in drug delivery. Focusing on cancer treatment, two promising implementations are combination therapy and targ[...]texto impreso
Gisbert Garzarán, Miguel ; Lozano Borregón, Daniel ; Matsumoto, Kotaro ; Komcatsu, Aoi ; Manzano García, Miguel ; Tamanoi, Fuyuhiko ; Vallet Regí, María | ACS PUBLICATIONS | 2021-02-17The several biological barriers that nanoparticles might encounter when administered to a patient constitute the major bottleneck of nanoparticle7 mediated tumor drug delivery, preventing their successful translation into the clinic and reducing[...]texto impreso
Gisbert Garzarán, Miguel ; Berkmann, Julia ; Giasafaki, Dimitra ; Lozano Borregón, Daniel ; Spyrou, Konstantinos ; Manzano García, Miguel ; Steriotis, Theodore A ; Duda, Georg ; Schmidt-Bleek, Katharina ; Charalambopoulou, Georgia ; Vallet Regí, María | ACS PUBLICATIONS | 2020-03-05In this work, two types of mesoporous carbon particles with different morphology, size and pore structure have been functionalized with a self-immolative polymer sensitive to changes in pH and tested as drug nanocarriers. It is shown that their [...]texto impreso
Cabañas Criado, Victoria ; Lozano Borregón, Daniel ; Torres-Pardo, A. ; Sobrino, C. ; González-Calvet, J. ; Arcos Navarrete, Daniel ; Vallet Regí, María | Elsevier | 2018-12-01Aminopropyl modified mesoporous SiO2 nanoparticles, MCM-41 type, have been synthesized by the co-condensation method from tetraethylorthosilicate (TEOS) and aminopropyltriethoxysilane (APTES). By means of modifying TEOS/APTES ratio we have carri[...]texto impreso
Martínez Carmona, Marina ; Lozano Borregón, Daniel ; Colilla Nieto, Montserrat ; Vallet Regí, María | Elsevier | 2017-11-07A novel multifunctional nanodevice based in doxorubicin (DOX)-loaded mesoporous silica nanoparticles (MSNs) as nanoplatforms for the assembly of different building blocks has been developed for bone cancer treatment. These building blocks consis[...]texto impreso
Ardura, Juan A. ; Portal Núñez, Sergio ; Lozano Borregón, Daniel ; Gutiérrez Rojas, Irene ; Sánchez Salcedo, Sandra ; López Herradón, Ana ; Mulero, Francisca ; Villanueva Penacarrillo, Maria L. ; Vallet Regí, María ; Esbrit, Pedro | Wiley | 2016-08Diabetes mellitus (DM) and aging are associated with bone fragility and increased fracture risk. Both (1-37) N- and (107-111) C-terminal parathyroid hormone-related protein (PTHrP) exhibit osteogenic properties. We here aimed to evaluate and com[...]texto impreso
The enormous versatility of mesoporous silica nanoparticles permits the creation of a large number of nanotherapeutic systems for the treatment of cancer and many other pathologies. In addition to the controlled release of small drugs, these mat[...]texto impreso
Current chemotherapy treatments lack of great selectivity towards tumoral cells, which 13 leads to nonspecific drug distribution and subsequent side effects. In this regard, the use of 14 nanoparticles able to encapsulate and release therapeutic[...]texto impreso
Lozano Borregón, Daniel ; Vallet Regí, María ; Manzano García, Miguel ; Mora Raimundo, Patricia | Future Medicine | 2020-10-14In this original editorial piece, María Vallet-Regí, Patricia Mora-Raimundo, Daniel Lozano and Miguel Manzano (all at the Universidad Complutense de Madrid, Spain) discuss the use of nanoparticles for the potential treatment of osteoporosis, in [...]texto impreso
Mora Raimundo, Patricia ; Lozano Borregón, Daniel ; Manzano García, Miguel ; Vallet Regí, María | American Chemical Society | 2019-05-09Osteoporosis is the most common disease involving bone degeneration. Current clinical treatments are not able to offer a satisfying curative effect, so the development of effective treatments is desired. Gene silencing through siRNA delivery has[...]texto impreso
Martínez Carmona, Marina ; Lozano Borregón, Daniel ; Baeza, Alejandro ; Colilla, Montserrat ; Vallet Regí, María | Royal Society of Chemistry | 2017-09-19A novel singlet-oxygen sensitive drug delivery nanocarrier able to release their cargo after exposure to visible (Vis) light of a common lamp is presented. This nanodevice is based on mesoporous silica nanoparticles (MSN) decorated with porphyri[...]texto impreso
Pérez, Rebeca ; Sánchez-Salcedo, Sandra ; Lozano Borregón, Daniel ; Heras, Clara ; Esbrit, Pedro ; Vallet Regí, María ; Salinas Sánchez, Antonio J. | MDPI AG | 2018-08-04Mesoporous Bioactive Glasses (MBGs) are a family of bioceramics widely investigated for their putative clinical use as scaffolds for bone regeneration. Their outstanding textural properties determine high bioactivity when compared with other bio[...]texto impreso
Heras, Clara ; Sánchez Salcedo, Sandra ; Lozano Borregón, Daniel ; Peña, Juan ; Esbrit, Pablo ; Vallet Regí, María ; Salinas Sánchez, Antonio J. | Elsevier | 2019-03-16There is an urgent need of biosynthetic bone grafts with enhanced osteogenic capacity. In this study, we describe the design of hierarchical meso-macroporous 3D-scaffolds based on mesoporous bioactive glasses (MBGs), enriched with the peptide os[...]
