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Bone infection is a feared complication following surgery or trauma that remains as an extremely difficult disease to deal with. So far, the outcome of therapy could be improved with the design of 3D implants, which combine the merits of osseous[...]texto impreso
Castillo, Rafael R. ; Lozano Borregón, Daniel ; González, Blanca ; Manzano García, Miguel ; Izquierdo-Barba, Isabel ; Vallet Regí, María | Taylor & Francis | 2019-03-22Introduction: Mesoporous silica nanoparticles (MSNs) are outstanding nanoplatforms for drug delivery. Herein, the most recent advances to turn MSN-based carriers into minimal side effect drug delivery agents are covered. Areas covered: This revi[...]texto impreso
Pedraza, Daniel ; Díez, Jaime ; Izquierdo-Barba, Isabel ; Colilla, Montserrat ; Vallet Regí, María | De Gruyter Open | 2018-01-24This manuscript reports an effective new alternative for the management of bone infection by the 5 development of an antibiotic nanocarrier able to penetrate bacterial biofilm, thus enhancing antimicrobial effectiveness. This nanosystem, also de[...]texto impreso
Álvarez, Rafael ; Muñoz-Piña, Sandra ; González, Maria U. ; Izquierdo-Barba, Isabel ; Fernández-Martín, Iván ; Rico, Victor J. ; Arcos Navarrete, Daniel ; García-Valenzuela, Aurelio ; Palmero, Alberto ; Vallet Regí, María ; González-Elipe, Agustín R. ; García-Martín, José R. | MDPI | 2019-08-28Based on an already tested laboratory procedure, a new magnetron sputtering methodology to simultaneously coat two-sides of large area implants (up to ~15 cm2) with Ti nanocolumns in industrial reactors has been developed. By analyzing the requi[...]texto impreso
Moreno Zafra, Víctor Manuel ; Alvarez Corchado, Elena ; Izquierdo-Barba, Isabel ; Baeza, Alejandro ; Serrano López, Juana ; Vallet Regí, María | Wiley Online Library | 2020-04-21One of the major concerns in the application of nanocarriers in oncology is their scarce penetration capacity in tumoral tissues, which drastically compromises the effectivity. Living organisms as cells and bacteria present the capacity to navig[...]texto impreso
Vallet Regí, María ; Lozano Borregón, Daniel ; González Ortiz, Blanca ; Izquierdo-Barba, Isabel | Wiley Online Library | 2020-05-26Chronic bone infection is considered as one of the most problematic biofilm-related infections. Its recurrent and resistant nature, high morbidity,prolonged hospitalization, and costly medical care expenses have driven the efforts of the scien[...]texto impreso
Cicuendez, Monica ; Portoles, Pilar ; Montes Casado, María ; Izquierdo-Barba, Isabel ; Vallet Regí, María ; Portolés Pérez, María Teresa | Royal Society of Chemistry | 2014-06-14The interaction of new nanocomposite mesoporous glass/hydroxyapatite (MGHA) scaffolds with immune cells involved in both innate and acquired immunity has been studied in vitro as an essential aspect of their biocompatibility assessment. Since th[...]texto impreso
Torres-Rodriguez, Carolina ; Portolés Pérez, M. T. ; Matesanz Sancho, María Concepción ; Linares, Javier ; Feito Castellano, María José ; Izquierdo-Barba, Isabel ; Esbrit, Pedro ; Vallet Regí, María | Elsevier | 2016-01-01Hypothesis: Dental bleaching with H2O2 is a common daily practice in dentistry to correct discoloration of anterior teeth. The aim of this study has been to determine whether this treatment of human teeth affects growth, differentiation and acti[...]texto impreso
Doadrio Villarejo, Antonio Luis ; Izquierdo-Barba, Isabel ; Colilla Nieto, Montserrat ; Martínez Alonso, África ; Sánchez Salcedo, Sandra ; García Fontecha, Ana ; Cabañas Criado, Maria Victoria ; Peña López, Juan ; Román Zaragoza, Jesús ; Salinas Sánchez, Antonio J. ; Doadrio Villarejo, Juan Carlos ; Gutiérrez Ríos, María Teresa ; Arcos Navarrete, Daniel ; Moreno Pérez, José Manuel ; Vallet Regí, María ; Sánchez Montero, José María | 2017-06-07Se ha construido una base de datos con las propiedades de los elementos químicos, isótopos naturales y artificiales de los elementos y el tiempo de semivida de los radiactivos, así como, la serie de la tabla periódica a la que pertenecen, caráct[...]texto impreso
Villegas, Fernanda ; Garcia-Uriostegui, Lorena ; Rodríguez, Ofelia ; Izquierdo-Barba, Isabel ; Salinas Sánchez, Antonio J. ; Toriz, Guillermo ; Vallet Regí, María ; Delgado, Ezequiel | MDPI | 2017Abstract: A facile strategy for zwitterionization of bioceramics based on direct incorporation of L-lysine amino acid via the ?-amino group onto mesoporous MCM-41 materials is proposed. FTIR studies of lysine-grafted MCM-41 (MCM-LYS) showed simu[...]texto impreso
González Ortiz, Blanca ; Colilla, Montserrat ; Díez, Jaime ; Pedraza, Daniel ; Guembe, Marta ; Izquierdo-Barba, Isabel ; Vallet Regí, María | Elsevie | 2018-03-01This work aims to provide an effective and novel solution for the treatment of infection by using nanovehicles loaded with antibiotics capable of penetrating the bacterial wall, thus increasing the antimicrobial effectiveness. These nanosystems,[...]texto impreso
Vallet Regí, María ; Colilla, Montserrat ; Izquierdo-Barba, Isabel ; Manzano García, Miguel | MDPI | 2017-12-25This manuscript reviews the recent progress on mesoporous silica nanoparticles as drug delivery systems. Their intrinsic structural, textural and chemical features permit to design versatile multifunctional nanosystems with the capability to tar[...]texto impreso
Cicuendez, Monica ; Doadrio Villarejo, Juan Carlos ; Hernandez, ana ; Portolés Pérez, María Teresa ; Izquierdo-Barba, Isabel ; Vallet Regí, María | Elsevier | 2017-11-09Multifunctional-therapeutic three-dimensional (3D) scaffolds have been prepared. These biomaterials are able to destroy the S. aureus bacterial biofilm and to allow bone regeneration at the same time. The present study is focused on the design o[...]texto impreso
Izquierdo-Barba, Isabel ; García Martín, José Miguel ; Álvarez, Rafael ; Palmero, Alberto ; Esteban, Jaime ; Pérez-Jorge Peremarch, María de la Concepción ; Arcos, Daniel ; Vallet Regí, María | Elsevier | 2015-03-15Bacterial colonization and biofilm formation on orthopedic implants is one of the worst scenarios in orthopedic surgery, in terms of both patient prognosis and healthcare costs. Tailoring the surfaces of implants at the nanoscale to actively pro[...]texto impreso
Both the prevalence of antibiotic resistance and the increased biofilm-associated infections are boosting the demand for new advanced and more effective treatment for such infections. In this sense, nanotechnology offers a ground-breaking platfo[...]
