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Colligris, Basilio ; Crooke, Almudena ; Huete Toral, Fernando ; Pintor, Jesús | Taylor & Francis | 2014-07Introduction: Dry eye disease is a common disorder provoking changes in tear film and ocular surface. Untreated dry eye could cause ocular infections, corneal ulcer and blindness. Only a few drugs are authorized so far for the treatment of dry e[...]texto impreso
Mediero Muñoz, Aránzazu ; Guzmán Aránguez, Ana Isabel ; Crooke, Almudena ; Peral Cerdá, Assumpta ; Pintor, Jesús | The Association for Research in Vision and Ophthalmology, Inc. | 2008-11Purpose. To investigate the role of ERK1/2 and RhoA/ROCK intracellular pathways in the modification of corneal re-epithelialization when stimulated by the diadenosine polyphosphates Ap4A and Ap3A. Methods. In wounded confluent SIRC (Statens Seru[...]texto impreso
Crooke, Almudena ; Guzmán Aránguez, Ana Isabel ; Mediero Muñoz, Aránzazu ; Alarma-Estrany, Pilar ; Carracedo Rodríguez, Juan Gonzalo ; Pelaez, Teresa ; Peral Cerdá, Assumpta ; Pintor, Jesús | Taylor & Francis | 2015-01Purpose: We have investigated the effect of melatonin and its analogues on rabbit corneal epithelial wound healing. Methods: New Zealand rabbits were anaesthetised and wounds were made by placing Whatman paper discs soaked in n-heptanol on the c[...]texto impreso
Navarro Gil, Francisco Javier ; Huete Toral, Fernando ; Crooke, Almudena ; Dominguez Godínez, Carmen Olalla ; Carracedo Rodríguez, Juan Gonzalo ; Pintor, Jesús | American Society for Pharmacology and Experimental Therapeutics | 2019-10Melatonin has been shown to enhance tear secretion associated with dinucleotide diadenosine tetraphosphate. This study investigated the isolated action of melatonin and its analogs, agomelatine, N-butanoyl-2-(2-methoxy-6H-isoindolo[2,1-a]indol-1[...]texto impreso
Crooke, Almudena ; Martínez Alberquilla, Irene ; García Montero, María ; Rico del Viejo, Laura ; Ruiz Alcocer, Javier ; Madrid Costa, David | Elsevier | 2020-11-13The inflammatory process plays a crucial role in frailty syndrome, which can appear in middle age and is associated with a poor health outcome. Consequently, gerontologists recommend screening inflammatory biomarkers in middle-aged adults to det[...]texto impreso
Crooke, Almudena ; Martínez Henández, Juan ; Martínez López, Joaquín ; Cruz Jentoft, Alfonso ; Huete Toral, Fernando ; Pintor, Jesús | Biomed Central Ltd | 2017-05-19Ageing involves a progressive decline of the body’s regulatory systems including immune system. Adenosine regulates immune function by interaction with its receptors, mainly adenosine A2A receptor, present on the surface of immune cells. Further[...]texto impreso
Pelaez, Teresa ; Mediero Muñoz, Aránzazu ; Alarma-Estrany, Pilar ; Loma Lozano, Patricia ; Guzmán Aránguez, Ana Isabel ; Crooke, Almudena ; Kolligris, Basilio ; Peral Cerdá, Assumpta ; Pintor, Jesús | Real Academia Nacional de Farmacia | 2007The research on the effect of melatonin on intraocular pressure (IOP) is reviewed from the hystorical point of view of our laboratory. The original idea of melatonin modulating intraocular pressure has been improved by using selective compounds[...]texto impreso
Huete Toral, Fernando ; Crooke, Almudena ; Martínez Águila, Alejandro ; Pintor, Jesús | Mary Ann Liebert | 2015-01-01Melatonin and its analog 5-MCA-NAT (5-methylcarboxyamino-N-acetyl tryptamine) are active compounds reducing intraocular pressure (IOP). This action is mediated through MT2 and the putative MT3 melatonin receptor, producing a transient reduction [...]texto impreso
Carpena Torres, Carlos ; Pintor, Jesús ; Pérez de Lara, María Jesús ; Huete Toral, Fernando ; Crooke, Almudena ; Pastrana, Cristina ; Carracedo Rodríguez, Juan Gonzalo | Hindawi Publishing Corporation | 2020-05-30Purpose. To optimize a rabbit dry eye model induced by topical instillation of benzalkonium chloride (BAC), reduce the days of instillation of the original model by increasing the concentration of BAC from 0.1% to 0.2%. Materials and Methods. [...]texto impreso
Carpena Torres, Carlos ; Pintor, Jesús ; Pérez de Lara, María Jesús ; Toral, Fernando ; Crooke, Almudena ; Pastrana, Cristina ; Carracedo Rodríguez, Juan Gonzalo ; Cayuela López, Ana ; Sorzano Sánchez, Óscar ; Charbel, Carla ; Garzón Jiménez, Nuria ; Carballo Álvarez, Jesús ; Diz Arias, Elena ; Fernández Jiménez, Elena ; Peral Cerdá, Assumpta ; Gómez Pedrero, José Antonio ; Durán Prieto, Elena ; López Alonso, José Manuel ; Fernández Torres, Miguel Ángel ; Guzmán Aránguez, Ana Isabel ; Gómez Manzanares, Ángela ; Vázquez Moliní, Daniel ; Martínez Antón, Juan Carlos ; Bernárdez Vilaboa, Ricardo ; Mayorga Pinilla, Santiago ; Álvarez Fernández-Balbuena, Antonio ; Benítez, AntoJ. ; El Youssfi, Asmae Igalla ; León Álvarez, Alejandro ; Palomo Álvarez, Catalina ; LLedó Mayans, Victoria Eugenia ; Awad Alkozi, Hanan ; Sánchez Naves, Juan ; Martínez Alberquilla, Irene ; García Montero, María ; Ruiz Alcocer, Javier ; Madrid Costa, David ; Martínez Florentín, Gema ; Papas, Eric B. ; Medrano Muñoz, Sandra Milena ; Molina, Nancy ; Jurado, Sandra ; Oliveiros López, Juan ; Platero Alvarado, Nadiuska Cristine ; Garrido Mercado, Rafaela ; Pérez Garmendia, Carlos ; Antona Peñalba, Beatriz ; Barrio de Santos, Ana Rosa ; González Pérez, Mariano ; Pérez Garmendia, Carlos ; Serramito Blanco, María ; Privado Aroco, Ana ; Almalki, Wael ; Bodas Romero, Julia ; Ouzzani, Mohamed ; Paune, Jaume ; Calderón García, Raquel ; Pitarch Velasco, Aida ; Cebrián, José Luis ; Sánchez Pérez, Isabel ; García Rojo, Marta María ; Bonnin Arias, Cristina ; Sánchez Ramos, Celia ; Gutiérrez Jorrín, Sara Carmen ; Rodríguez Alonso, Xabier ; Laucirica Sáenz, Gorka ; Arranz Márquez, Esther ; Alonso Castellanos, Miriam ; Teus Guezala, Miguel Ángel ; Hernández Verdejo, José Luis ; Mármol Errasti, Esther ; Martín García, Beatriz ; Arriola Villalobos, Pedro ; Gómez de Liaño, Rosario ; Mínguez Caro, N ; Orduña Azcona, Javier ; Navarro Gil, Francisco Javier ; Huete Toral, Fernando ; Rodríguez Pomar, Candela ; Pastrana Robles, Cristina ; Martínez Águila, Alejandro ; Martín Gil, Alba ; Tomé de la Torre, Miguel Ángel | Facultad de Óptica y Optometría (UCM) | 2020Por cuarto año consecutivo los doctorandos de la Facultad de Óptica y Optometría de la Universidad Complutense de Madrid cuentan con un congreso propio organizado por y para ellos, el 4º PhDAY- FOO. Se trata de un congreso gratuito abierto en [...]texto impreso
Carracedo Rodríguez, Juan Gonzalo ; Recchioni, Alberto ; Alejandre Alba, Nicolás ; Martín Gil, Alba ; Crooke, Almudena ; Jiménez Alfaro-Morote, Ignacio ; Pintor, Jesús | Taylor & Francis | 2015-11Purpose: To compare signs and symptoms of dry eye in keratoconus (KC) patients versus healthy subjects. Methods: A total of 15 KC patients (KC group, n?=?15 eyes) and 16 healthy subjects (control group, 16 eyes) were enrolled in this study. The [...]texto impreso
The eye is continuously exposed to solar UV radiation and pollutants, making it prone to oxidative attacks. In fact, oxidative damage is a major cause of age-related ocular diseases including cataract, glaucoma, age-related macular degeneration [...]texto impreso
Carracedo Rodríguez, Juan Gonzalo ; Crooke, Almudena ; Guzmán Aranguez, Ana María ; Pintor, Jesús | Elsevier | 2016-07-14Dinucleoside polyphosphates comprises a group of dinucleotides formed by two nucleosides linked by a variable number of phosphates, abbreviated NpnN (where n represents the number of phosphates). These compounds are naturally occurring substance[...]texto impreso
Martínez Alberquilla, Irene ; García Montero, María ; Ruiz Alcocer, Javier ; Crooke, Almudena ; Madrid Costa, David | Elsevier | 2020-11-23Purpose: To evaluate visual function, ocular surface integrity and dry eye symptoms with an extended depth-of-focus (EDOF) design and a conventional multifocal (MF) contact lens (CL) after 15 days of wear. Methods: A crossover single mask random[...]
