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Estañ, María Cristina ; Calviño, Eva ; Blas, Elena de ; Boyano Adánez, María del Carmen ; Mena, María Luz ; Gómez Gómez, M.Milagros ; Rial, Eduardo ; Aller, Patricio | Elsevier | 2012While the anti-tumor efficacy of 2-deoxy-D-glucose (2-DG) is normally low in monotherapy, it may represent a valuable radio- and chemo-sensitizing agent. We here demonstrate that 2–10 mM 2-DG cooperates with arsenic trioxide (ATO) and other anti[...]texto impreso
Moraleja, I. ; Mena, María Luz ; Lázaro, A. ; Neumann, B. ; Tejedor, A. ; Jakubowski, N. ; Gómez Gómez, M.Milagros ; Esteban Fernández, D. | Elsevier | 2018Laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) has been revealed as a convenient technique for trace elemental imaging in tissue sections, providing elemental 2D distribution at a quantitative level. For quantification p[...]texto impreso
Mena, María Luz ; Moreno Gordaliza, Estefanía ; Moraleja San José, Irene ; Cañas Montalvo, Benito ; Gómez Gómez, M.Milagros | Elsevier | 2011In this work a 2D electrophoretic separation procedure able to maintain the integrity of platinum–protein bonds has been developed. The method is based on the use of sequential OFFGEL isoelectric focussing (IEF) and PAGE. A systematic study of t[...]texto impreso
Moraleja San José, Irene ; Esteban Fernández, Diego ; Lázaro, Alberto ; Humanes, Blanca ; Neumann, Boris ; Tejedor, Alberto ; Mena, María Luz ; Jakubowski, Norbert ; Gómez Gómez, M.Milagros | Springer | 2016The study of the distribution of the cytostatic drugs cisplatin, carboplatin, and oxaliplatin along the kidney may help to understand their different nephrotoxic behavior. Laser ablation inductively coupled plasma mass spectrometry (LAICP-MS) al[...]texto impreso
Moraleja, I ; Moreno Gordaliza, Estefanía ; Mena, María Luz ; Gómez Gómez, M.Milagros | Elsevier | 2014The analysis of the complexes between metal-based chemotherapeutic drugs and proteins in biological samples, such as cisplatin or oxaliplatin, can be a challenge due to metal strong reactivity towards S-donor molecules such as dithiothreitol (DT[...]
